Magneto-Induced Hyperthermia and Temperature Detection in Single Iron Oxide Core-Silica/Tb3+/Eu3+(Acac) Shell Nano-Objects

Abstract

Multifunctional nano-objects containing a magnetic heater and a temperature emissive sensor in the same nanoparticle have recently emerged as promising tools towards personalized nanomedicine permitting hyperthermia-assisted treatment under local temperature control. However, a fine control of nano-systems’ morphology permitting the synthesis of a single magnetic core with controlled position of the sensor presents a main challenge. We report here the design of new iron oxide core–silica shell nano-objects containing luminescent Tb3+/Eu3+-(acetylacetonate) moieties covalently anchored to the silica surface, which act as a promising heater/thermometer system. They present a single magnetic core and a controlled thickness of the silica shell, permitting a uniform spatial distribution of the emissive nanothermometer relative to the heat source. These nanoparticles exhibit the Tb3+ and Eu3+ characteristic emissions and suitable magnetic properties that make them efficient as a nanoheater with a Ln3+-based emissive self-referencing temperature sensor covalently coupled to it. Heating capacity under an alternating current magnetic field was demonstrated by thermal imaging. This system offers a new strategy permitting a rapid heating of a solution under an applied magnetic field and a local self-referencing temperature sensing with excellent thermal sensitivity (1.64%·K−1 (at 40 °C)) in the range 25–70 °C, good photostability, and reproducibility after several heating cycles.

Wet chemical synthesis of TGA capped Ag2S nanoparticles and their use for fluorescence imaging and temperature sensing in living cells

“…S4 in ESI†). These values are of the same order and even higher than those recently reported for fluorescent nano-thermometers, 24,50–52 which makes of the as-prepared nanoparticles convenient for temperature sensing operating in the NIR biological windows. However, the shape, the position and the intensity of the emission of Ag 2 S nanoparticles may be influenced by water absorption, which depend on temperature.…”

Eu3+ and Tb3+ coordination compounds with phenyl-containing carbacylamidophosphates: comparison with selected Ln3+ β-diketonates

“…From a theoretical perspective, lanthanide-base β-diketonates have been widely studied in the literature ( Moura et al, 2016 ; Carlos et al, 2005 ; Divya et al, 2011 ; Petrov et al, 2015 ; Arrué et al, 2021 ; Malta et al, 1997 ; Singh et al, 2017 ; Santos et al, 2020 ; dos Santos et al, 2010 ; Batista et al, 1998 ; Lima et al, 2020 ; Fu et al, 2019 ; Nigoghossian et al, 2022 ). Some computational studies have helped in understanding the molecular and electronic structures of lanthanide β-diketonates ( Fu et al, 2019 ; Lima et al, 2020 ; Arrué et al, 2021 ) as well as in exploring their stability ( Petrov et al, 2015 ).…”

Editorial for Special Issue “Luminescent Colloidal Nanocrystals”

“…Interestingly, some colloidal nanoparticles may serve as multifunctional nanoobjects that make them promising for various areas including nanomedicine. Nigoghossian et al [ 6 ] proposed the design of multifunctional iron oxide core–silica shell nanoparticles acting as both a magnetic heater and a self-referencing temperature emissive sensor. These multifunctional magneto-luminescent nanoparticles possess good thermal- and photostability and are promising for magnetothermia-related applications.…”