Magneto‐Controllable Capture and Release of Cancer Cells by Using a Micropillar Device Decorated with Graphite Oxide‐Coated Magnetic Nanoparticles

Yu, Xiaolei; He, Rongxiang; Li, Shasha; Cai, Bo; Zhao, Libo; Liao, Lei; Liu, Wei; Zeng, Qian; Wang, Hao; Guo, Shishang; Zhao, Xingzhong

doi:10.1002/smll.201300169

Cited by 87 publications

(72 citation statements)

References 35 publications

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“…148 Purity was not reported for the nanotextured device. 151 However, a similar study that used anti-CD146 Abs coated to electrospun nanofibers showed high nonspecific binding. 150 …”

Section: Microfluidic-based Biological Ctc Selectionmentioning

confidence: 99%

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

et al. 2017

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We present a critical review of microfluidic technologies and material effects on the analyses of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients. CTCs are a minimally invasive source of clinical information that can be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer. The performance of CTC isolation technologies depends on microfluidic architectures, the underyling principles of isolation, and the choice of materials. In this review, we present a critical review of the fundamental principles used in these technologies and discuss their performance. We also give context to how CTC isolation technologies enable downstream analysis of selected CTCs in terms of detecting genetic mutations and gene expression that could be used to gain information that may affect patient outcome.

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“…148 Purity was not reported for the nanotextured device. 151 However, a similar study that used anti-CD146 Abs coated to electrospun nanofibers showed high nonspecific binding. 150 …”

Section: Microfluidic-based Biological Ctc Selectionmentioning

confidence: 99%

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

et al. 2017

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“…In an alternative approach, a nickel micropillar device coated with graphite oxide/magnetite NPs functionalized with antiepithelial cell adhesion molecule (EpCAM) antibody has been designed for magneto-controllable capture and release of cancer cells [62]. The EpCAM antigen is overexpressed on the membrane of most tumors.…”

Section: Capture and Separation Of Cellsmentioning

confidence: 99%

Multifunctional carbon nanomaterial hybrids for magnetic manipulation and targeting

Chau

Ménard‐Moyon

Kostarelos

et al. 2015

Biochemical and Biophysical Research Communications

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“…123 Magnetic nanoparticles were embedded in graphite oxide sheets, which subsequently underwent NHS/EDC chemistry to bind streptavidin. Biotinylated anti-EpCAM was then used for functionalization.…”

Section: Ctc Devices Incorporating Nanomaterialsmentioning

confidence: 99%

Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis

2014

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Circulating tumor cells (CTCs) are low frequency cells found in the bloodstream after having been shed from a primary tumor. These cells are research targets because of the information they may potentially provide about both an individual cancer as well as the mechanisms through which cancer spreads in the process of metastasis. Established technologies exist for CTC isolation, but the recent progress and future of this field lie in nanomaterials. In this review, we provide perspective into historical CTC capture as well as current research being conducted, emphasizing the significance of the materials being used to fabricate these devices. The modern investigation into CTCs initially featured techniques that have since been commercialized. A major innovation in the field was the development of a microfluidic capture device, first fabricated in silicon and followed up with glass and thermopolymer devices. We then specifically highlight the technologies incorporating magnetic nanoparticles, carbon nanotubes, nanowires, nanopillars, nanofibers, and nanoroughened surfaces, graphene oxide and their fabrication methods. The nanoscale provides a new set of tools that has the potential to overcome current limitations associated with CTC capture and analysis. We believe the current trajectory of the field is in the direction of nanomaterials, allowing the improvements necessary to further CTC research.

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Magneto‐Controllable Capture and Release of Cancer Cells by Using a Micropillar Device Decorated with Graphite Oxide‐Coated Magnetic Nanoparticles

Cited by 87 publications

References 35 publications

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

Multifunctional carbon nanomaterial hybrids for magnetic manipulation and targeting

Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis

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