Magnetization transfer MRS

Leibfritz, Dieter; Dreher, Wolfgang

doi:10.1002/nbm.681

Cited by 75 publications

(84 citation statements)

References 65 publications

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“…[41][42][43] MT-MRS is discussed further in the article by D. Leibfritz and W. Dreher in this issue. 44 It is still possible that this effect will have significant application in understanding tissue metabolism in the future. period, researchers have characterized the underlying NMR physics, exchange and relaxation rates that govern MT, although detailed understanding of the chemistry and molecular interactions is still needed.…”

Section: Applications In Imagingmentioning

confidence: 99%

Magnetization transfer in MRI: a review

2001

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This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT-induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed.

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Section: Applications In Imagingmentioning

confidence: 99%

Magnetization transfer in MRI: a review

2001

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“…Magnetization transfer phenomena in skeletal muscle have also been investigated with 1 H MRS. These studies were inspired by the remarkable finding in 1 H MRS studies of rat brain by Leibfritz and colleagues (110,111) that off-resonance saturation leads to a strong reduction in the PCr/Cr proton signal. Subsequently, De Graaf et al (112) demonstrated that other metabolites in rat brain, including glutamate/glutamine and lactate, also exhibit a significant off-resonance MT effect.…”

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confidence: 99%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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“…In vivo fluxes between PCr and ATP in rat brain and skeletal muscle were quantified using MT in the 1980s (112). Since then, this technique has been widely applied to measure CK reaction rate in heart, brain, and skeletal muscle (17,73,(112)(113)(114)(115)(116)(117). P i -to-ATP flux has also been investigated in liver, heart, Quant Imaging Med Surg 2017;7(6):707-726 qims.amegroups.com brain, and skeletal muscle (17,(118)(119)(120)(121).…”

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confidence: 99%

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

Liu

2017

Quant. Imaging Med. Surg.

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Many human diseases are caused by an imbalance between energy production and demand.Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide the unique opportunity for in vivo assessment of several fundamental events in tissue metabolism without the use of ionizing radiation. Of particular interest, phosphate metabolites that are involved in ATP generation and utilization can be quantified noninvasively by phosphorous-31 ( 31 P) MRS/MRI. Furthermore, 31 P magnetization transfer (MT) techniques allow in vivo measurement of metabolic fluxes via creatine kinase (CK) and ATP synthase. However, a major impediment for the clinical applications of 31 P-MRS/MRI is the prohibitively long acquisition time and/or the low spatial resolution that are necessary to achieve adequate signal-to-noise ratio. P-MRS/MRI techniques. Applications of these techniques to the investigation of a specific physiology/pathology will be discussed without detailed description. Interested readers are referred to recent review articles on the applications of 31 P-MRS/MRI in metabolic characterization of skeletal muscle (10-12), heart (13), brain (14), and liver (11), as well as in diseases such as cancer (15), heart failure (16), and obesity and diabetes (17,18). Historical perspectiveThe use of 31 P-MRS for metabolic investigations dates back to 1960. Cohn and Hughes were the first to obtain a high-resolution 31 P spectrum of a solution of ATP (19). In addition, they also observed a dependence of the chemical shifts of the phosphorus nuclei of ATP on the pH of the solution. In parallel to the early development of MRI methods by Lauterbur (20), the entire 1970s also witnessed the rapid advance of 31 P-MRS in metabolic investigation of a broad range of biological systems. In 1973, Moon and Richards performed the first 31 P-MRS study that measured intracellular pH in human red blood cells (21). In the following year, Henderson and colleagues obtained the first 31 P spectrum of ATP from human red blood cells (22). At the same time, the Oxford team led by Radda performed the first experiment to acquire 31 P spectra from an intact organ, i.e., the excised and superfused muscle of rat hindlimb (23). The first in vivo 31 P-MRS study was performed on mouse brain by Chance et al. (24). Within the short span of one decade, organelles including mitochondria (25,26) and chromaffin granules (27), cells including Escherichia coli (28), yeast (29), and hepatocytes (30), and organs including skeletal muscle (31,32), heart (33-35), brain (36), kidney (37), and liver (38,39) have all been studied using 31 P-MRS.It is worth noting that most of these organ studies were performed on excised organs to avoid the need for spatial localization. Although Lauterbur has demonstrated the feasibility of imaging water protons (20), it was considered impractical for 31 P imaging of living systems because of the low sensitivity and difficulties with spectral resolution.The 1980s began with the publication of two important studies that aimed a...

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Magnetization transfer MRS

Cited by 75 publications

References 65 publications

Magnetization transfer in MRI: a review

Magnetization transfer in MRI: a review

Dynamic MRS and MRI of skeletal muscle function and biomechanics

Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review

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