Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

Es, Ad C. G. M. van; Flier, Wiesje M. van der; Admiraal-Behloul, Faiza; Olofsen, Hans; Bollen, E.; Middelkoop, Huub A. M.; Weverling-Rijnsburger, Annelies W. E.; Westendorp, Rudi G.J.; Buchem, Mark A. van

doi:10.1016/j.neurobiolaging.2005.09.042

Cited by 30 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…147 MT-MRI measures derived from the whole of the brain tissue, as well as those from temporal and frontal lobes taken in isolation, were strongly correlated with global cognitive deterioration and impairment of several functions in both AD and MCI patients. 147 A recent MT-MRI study confirmed that the extent of overall NAWM and GM damage is similar in patients with AD and MCI, 148 again suggesting that occult structural brain changes may be present before the onset of cognitive deficits. Patients with early AD have also been found to have reduced MTR values of the hippocampus.…”

Section: Alzheimer's Disease (Ad) and Other Dementiasmentioning

confidence: 92%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

View full text Add to dashboard Cite

Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

show abstract

Section: Alzheimer's Disease (Ad) and Other Dementiasmentioning

confidence: 92%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

View full text Add to dashboard Cite

show abstract

“…A low peak height of the MTR histogram indicates reduced capacity of the macromolecules in brain tissue to exchange magnetization with the surrounding water molecules, reflecting structural brain damage [14]. MTI has the advantage of being non-invasive and easy to administer, whilst having been proved to be sensitive for the first microstructural brain changes in different neurodegenerative disorders, like Alzheimer’s disease (AD) and Parkinson’s disease (PD), even before volumetric alterations [2, 16, 29, 33, 36, 37]. In mild cognitive impairment (MCI), which has become increasingly recognized as a transitional phase between normal old age and AD, abnormal MTR values of the brain parenchyma could be demonstrated without evidence of atrophy [33].…”

Section: Introductionmentioning

confidence: 99%

“…Although MTI was initially developed to investigate white matter changes in multiple sclerosis (MS), it was demonstrated to be sensitive for changes in tissue structure of the grey matter as well [13, 31, 37]. This, and the sensitivity for histopathological changes preceding atrophy, makes MTI an attractive tool in studying the earliest diffuse brain changes related to HD in both grey matter and white matter.…”

Section: Introductionmentioning

confidence: 99%

Magnetization transfer imaging in ‘premanifest’ Huntington’s disease

et al. 2009

View full text Add to dashboard Cite

To investigate whether magnetization transfer imaging (MTI) is a useful detector of diffuse brain abnormalities in ‘premanifest’ carriers of the Huntington’s disease (HD) gene mutation. Furthermore we examined the relations between MTI, clinical measures and CAG repeat length. Sixteen premanifest carriers of the HD gene without motor manifestation and 14 non-carriers underwent a clinical evaluation and a MRI scan. MTI analysis of whole brain, grey matter and white matter was performed producing magnetization transfer ratio (MTR) histograms. A lower peak height of the grey matter MTR histogram in carriers was significantly associated with more UHDRS motor abnormalities. Furthermore, a lower peak height of the whole brain, grey and white matter was strongly associated with a longer CAG repeat length. MTI measures themselves did not differ significantly between carriers and non-carriers. In premanifest HD mutation carriers, a lower MTR peak height, reflecting worse histological brain composition, was related to subtle motor abnormalities and higher CAG repeat length. Although we could not detect altered MTI characteristics in carriers of the HD gene mutation without clinical manifestations, we did provide evidence that the MTR peak height might reflect genetic and subclinical disease burden and may be of value in monitoring further disease progression and provide insight in clinical heterogeneity.

show abstract

“…Furthermore, converters to AD exhibited lower NAA/Cr ratios in paratrigonal WM than those who remained clinically stable 17. WM abnormalities in MCI were also assessed using DTI3 and magnetization transfer imaging 13. Together, the studies suggest vulnerability of WM in MCI similar to AD.…”

mentioning

confidence: 98%

Regional Myo-inositol Concentration in Mild Cognitive Impairment Using 1H Magnetic Resonance Spectroscopic Imaging

Siger¹,

Schuff

Zhu

et al. 2009

Alzheimer Disease &Amp; Associated Disorders

View full text Add to dashboard Cite

The goal was to assess regional patterns of metabolite abnormalities in mild cognitive impairment (MCI) and Alzheimer disease (AD) patients using proton magnetic resonance spectroscopy imaging at 1.5 Tesla. Fourteen MCI, 17 AD, and 16 healthy control (HC) subjects were studied. MCI was associated with higher myo-inositol (mIn) concentration in right parietal white matter compared with HC and lower mIn levels in frontal white matter compared with AD. AD was associated with higher mIn concentration in frontal and parietal white matter compared with HC. N-acetylaspartate (NAA) concentration of white matter was similar in all groups, whereas NAA concentration of gray matter showed a trend toward lower values in the right parietal lobe in AD compared with MCI and HC. A mIn increase in white matter in absence of significant NAA reduction suggests that mIn is a more robust and sensitive marker of white matter pathology in AD and MCI than NAA. Furthermore, the dissociation between mIn and NAA alterations in white matter could provide important information regarding the role of glial and neuronal damage in MCI and AD. Keywords mild cognitive impairment; H-MRS; Alzheimer diseaseThere is growing evidence in Alzheimer disease (AD) for a cerebral disconnection syndrome that involves both gray matter (GM) and white matter (WM) 1 besides the welldocumented pathology of neuronal cell bodies, which primarily include cortical and hippocampal GM locations. 1 Evidence for a more prominent role of WM in AD pathology comes from histopathologic studies showing a differential myelin breakdown of connection fibers that resembles the progressive regional spread of the pathognomonic lesions of AD (neuritic plaques and neurofibrillary tangles). 2 In addition, in vivo diffusion tensor imaging (DTI) studies on patients suggest progressive disintegration of WM fibers in AD, such as the cingulum bundle. 3,4 Proton magnetic resonance spectroscopy ( 1 H MRS) studies of WM integrity in AD reported abnormal metabolite concentrations, particularly decreased N-acetylaspartate Reprints: Małgorzata Siger, MD, PhD, Department of Neurology, Medical University of Lodz, Kopcińskiego 22, (NAA), a putative marker of neuronal processes 5 and increased myo-inositol (mIn), a proposed marker for gliosis. 6 In addition to myelin breakdown, there is also accumulative evidence that inflammation expressed as reactive microglial activation, reactive astrocytosis, and presence of inflammatory mediators could be an important pathogenetic factor for AD. 7 Neuroinflammatory species like activated microglia surrounding senile plaques and increased level of cytokines, chemokines, and free radical have been observed in AD. 7 These processes might develop in response to amyloid deposition and the associated loss of cerebral tissue. Inflammation is also consistent with MRS findings of increased mIn 8 and DTI findings of increased diffusivity 9 in AD. A better understanding of WM abnormalities in AD and potential targets for intervention to prevent cognitive decline h...

show abstract

Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

Cited by 30 publications

References 32 publications

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Magnetization transfer imaging in ‘premanifest’ Huntington’s disease

Regional Myo-inositol Concentration in Mild Cognitive Impairment Using 1H Magnetic Resonance Spectroscopic Imaging

Contact Info

Product

Resources

About