Magnetization transfer for the assessment of bowel fibrosis in patients with Crohn’s disease: initial experience

Pazahr, Shila; Blume, Iris; Frei, Pascal; Chuck, Natalie; Nanz, Daniel; Rogler, Gerhard; Patak, Michael A.; Boss, Andreas

doi:10.1007/s10334-012-0355-2

Cited by 82 publications

(67 citation statements)

References 20 publications

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“…Animal experiments using the purified peptidoglycan-polysaccharide rat colitis model have demonstrated the feasibility of MT-MRI in measuring the degree of intestinal fibrosis [32][33][34] . Initial data in patients confirm the potential of this imaging modality in revealing significant differences of the MT ratio in gut segments with fibrosis compared to normal or inflamed tissue [35,36] .…”

Section: Evaluation Of Strictures In CDsupporting

confidence: 55%

Imaging in Inflammatory Bowel Diseases - Magnetic Resonance Imaging

Herfarth

Schreyer

2015

Dig Dis

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Diagnostic imaging techniques play an important role in the diagnosis and management of patients with inflammatory bowel diseases (IBDs). The approach should be guided by considerations of diagnostic accuracy, concerns about patient exposure to ionizing radiation, local expertise and tolerance of the endoscopic and/or imaging technique. In regard to the clinical diagnostic value (sensitivity, specificity and accuracy), no significant differences exist between CT and MRI for the evaluation of the extent of inflammation, stricturing, penetrating disease or extraluminal complications such as abscesses. Due to the absence of radiation exposure, MRI of the intestine is recommended as the first-line imaging modality in patients with suspected or established IBD. The focus of this review is the latest developments in MRI techniques to detect IBDs. Specifically, the use of new indices for the grading of inflammation or assessing bowel damage as well as innovative experimental approaches such as diffusion-weighted imaging or magnetization-transfer MRI to evaluate and quantify the degree of intestinal inflammation and fibrosis in stricturing Crohn's disease are discussed.

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Section: Evaluation Of Strictures In CDsupporting

confidence: 55%

Imaging in Inflammatory Bowel Diseases - Magnetic Resonance Imaging

Herfarth

Schreyer

2015

Dig Dis

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“…Animal experiments using the purified peptidoglycan-polysaccharide rat colitis model have demonstrated the feasibility of MT-MRI to measure the degree of intestinal fibrosis [40,41]. Initial data in patients confirm the potential of this imaging modality in revealing significant differences of the MT ratio in gut segments with fibrosis compared to normal or inflamed tissue [42,43]. Based on these pilot studies, MT-MRI needs further evaluation in stringent prospective trials correlating the MT ratio with the response to medical therapy or histologic findings of resected strictures.…”

Section: Perspectives In Imaging Of Ibd Patientsmentioning

confidence: 74%

Update Imaging in Inflammatory Bowel Diseases

Herfarth¹

2013

Dig Dis

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Imaging is a central component of the diagnostic process in inflammatory bowel diseases. This review summarizes the recent progress of various most commonly used imaging modalities including computed tomography enterography, magnetic resonance enterography and capsule endoscopy. Advantages and disadvantages of each imaging protocol in suspected and established inflammatory bowel diseases are reviewed and brought into context in proposed diagnostic algorithms.

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“…It has been shown previously that magnetization transfer (MT) imaging is not only a valuable method to monitor diseases such as multiple sclerosis (19,20) or bowel fibrosis in Crohn disease (21), but it can also be used to T he quality of life of patients with urinary incontinence is markedly compromised (1). A conservative estimate is that urinary incontinence affects approximately 20% of women, but in fact, the prevalence may be as high as 50% in elderly women (2).…”

Section: Methodsmentioning

confidence: 99%

Magnetization Transfer MR Imaging to Monitor Muscle Tissue Formation during Myogenic in Vivo Differentiation of Muscle Precursor Cells

Rottmar¹,

Haralampieva²,

Salemi³

et al. 2016

Radiology

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Purpose To determine whether magnetization transfer (MT) magnetic resonance (MR) imaging may serve as a quantitative measure of the degree of fiber formation during differentiation of muscle precursor cells into engineered muscle tissue as a potential noninvasive monitoring tool in mice. Materials and Methods The study was approved by the local ethics committee (no. StV 01/2008) and the local Veterinary Office (license no. 99/2013). Human muscle progenitor cells (hMPCs) derived from rectus abdominis muscles were subcutaneously injected into CD-1 nude mice (CD-1 nude mice, Crl:CD1-Foxn1(nu); Charles River Laboratories, Wilmington, Mass) for development of muscle tissue. The mice underwent MR imaging examinations at 4.7 T at days 1, 3, 7, 14, 21, and 28 after cell transplantation by using a gradient-echo sequence with an MT prepulse and systematic variation of the off-resonance frequency (50-37 500 Hz) at an amplitude of 800°. Direct saturation was estimated from a Bloch equation simulation. The MT ratio (MTR) was correlated to immunohistochemistry findings, Western blot results, and results of myography. Data were analyzed by using one-way or two-way analysis of variance with the Sidak or Tukey multiple comparisons test. Results In the reference skeletal muscle, highest MT was found for 2500 Hz off-resonance frequency with an MTR ± standard deviation of 57.5% ± 3.5. The developing muscle tissue exhibited increasing MT values during the 28 days of myogenic in vivo differentiation and did not reach the values of native skeletal muscle. Mean values of MTR (2500 Hz) for hMPCs were 27.6% ± 6.3 (day 1), 24.7% ± 8.7 (day 3), 28.2% ± 5.7 (day 7), 35.9% ± 5.0 (day 14), 37.0% ± 7.9 (day 21), and 39.9% ± 8.1 (day 28). The results from MT MR imaging correlated qualitatively well with muscle tissue expression of specific skeletal markers, as well as muscle contractility. Conclusion MT MR imaging may be used to noninvasively monitor the process of myogenic in vivo differentiation of hMPCs as a biomarker of the quantity and quality of muscle fiber formation.

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Magnetization transfer for the assessment of bowel fibrosis in patients with Crohn’s disease: initial experience

Abstract: MT imaging of the small bowel wall is feasible in humans with sufficient image quality and may help with the identification of fibrotic scarring in patients with CD.

Cited by 82 publications

References 20 publications

Imaging in Inflammatory Bowel Diseases - Magnetic Resonance Imaging

Imaging in Inflammatory Bowel Diseases - Magnetic Resonance Imaging

Update Imaging in Inflammatory Bowel Diseases

Magnetization Transfer MR Imaging to Monitor Muscle Tissue Formation during Myogenic in Vivo Differentiation of Muscle Precursor Cells

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