Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances

Revia, Richard A.; Zhang, Miqin

doi:10.1016/j.mattod.2015.08.022

Cited by 516 publications

(331 citation statements)

References 101 publications

Supporting

Mentioning

312

Contrasting

Unclassified

Order By: Relevance

“…3 Superparamagnetic iron oxide nanoparticles (SPIONs) could be used in a combined manner, ie, not only as contrast agents for diagnostics and treatment monitoring but also as active substances for medical treatment. 4 In many cases, SPIONs represent a novel platform for simultaneous therapy and diagnostics (theranostics) in oncology. [5][6][7] Recently, it has been found that iron oxide nanoparticles are even capable of inhibiting tumor growth by stimulating macrophages.…”

Section: Introductionmentioning

confidence: 99%

Low toxic maghemite nanoparticles for theranostic applications

Kuchma¹,

Zolotukhin²,

Belanova³

et al. 2017

IJN

View full text Add to dashboard Cite

Background Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine. Methods Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing). Results TEM showed that the majority of the obtained nanoparticles were almost spherical and did not exceed 20 nm in diameter. The averaged DLS hydrodynamic size was found to be ~33 nm, while that of nanocrystallites estimated by XRD waŝ16 nm. Both XRD and XPS studies evidenced the maghemite (γ-Fe 2 O 3 ) atomic and electronic structure of the synthesized nanoparticles. The XANES data analysis demonstrated the structure of the nanoparticles being similar to that of macroscopic maghemite. The Mossbauer spectroscopy revealed the γ-Fe 2 O 3 phase of the nanoparticles and vibration magnetometry study showed that reactive oxygen species in HeLa cells are generated both in the cytoplasm and the nucleus. Conclusion Quasispherical Fe 3+ SPIONs having the maghemite structure with the average size of 16 nm obtained by using the fast microwave synthesis technique are expected to be of great value for theranostic applications in oncology and multimodal anticancer therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Low toxic maghemite nanoparticles for theranostic applications

Kuchma¹,

Zolotukhin²,

Belanova³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…In recent years, the synthesis of magnetic iron oxide nanoparticles (particularly magnetite -Fe 3 O 4 ) has been intensively explored with a view to biomedical applications such as targeted drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia [1][2][3][4][5][6][7][8] . Multifunctional materials are attractive because they may combine properties, which allow manipulation chemical functionalities, playing a key role in different applications.…”

Section: Introductionmentioning

confidence: 99%

Luminescent and Magnetic Properties of Fe3O4@SiO2:phen:Eu3+

2017

View full text Add to dashboard Cite

Magnetite was doped with rare earth ions (europium) to produce core-shell materials with both magnetic and luminescent properties, i.e., a magnetic Fe 3 O 4 oxide core and a SiO 2 :phen:Eu 3+ shell. The resulting material was analyzed by X-ray powder diffraction and transmission electron microscopy, and subjected to magnetic and luminescence emission measurements. All the synthesized materials exhibited superparamagnetic behavior and luminescence emission. The magnetic behavior of Fe 3 O 4 and luminescence emission of SiO 2 :phen:Eu 3+ of the materials were compared to precursors.

show abstract

“…MRI is considered one of the most promising non-invasive diagnostic tool in medical science since it provides 3D anatomical images with high spatial resolution in the submillimeter range and high soft tissue contrast [11]. Several SPION preparations have been approved by US FDA for clinical use as magnetic resonance (MR) CAs, such as Endorem R for liver imaging [12]. The successful biomedical application of a nanomaterial is a reflection of its adequate design.…”

Section: Introductionmentioning

confidence: 99%

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

View full text Add to dashboard Cite

Aim:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T 2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem R . The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T 2 contrast agent with a higher r 2 /r 1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.Lay abstract: Several superparamagnetic iron oxide nanoparticles (SPIONs) preparations have been approved by US FDA for clinical use as MRI contrast agents. In recent years, we have been developing a synthetic multifunctional platform for SPIONs based on the use of polymers. In this report, we explored the diagnostic potential of these nanoparticles (herein called bioferrofluids) as an MRI contrast agent and their uptake in liver, without neglecting their toxicological effects. Results show that our bioferrofluids are a good T 2 contrast agent without any observed toxicity in liver.

show abstract

Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances

Cited by 516 publications

References 101 publications

Low toxic maghemite nanoparticles for theranostic applications

Low toxic maghemite nanoparticles for theranostic applications

Luminescent and Magnetic Properties of Fe3O4@SiO2:phen:Eu3+

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Contact Info

Product

Resources

About

Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances

Cited by 516 publications

References 101 publications

Low toxic maghemite nanoparticles for theranostic applications

Low toxic maghemite nanoparticles for theranostic applications

Luminescent and Magnetic Properties of Fe3O4@SiO2:phen:Eu3+

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

Contact Info

Product

Resources

About

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver