Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

Nosrati, Hamed; Ghaffarlou, Mohammadreza; Salehiabar, Marziyeh; Mousazadeh, Navid; Abhari, Fatemeh; Barsbay, Murat; Ertaş, Yavuz Nuri; Rashidzadeh, Hamid; Mohammadi, Ali; Nasehi, Leila; Rezaeejam, Hamed; Davaran, Soodabeh; Ramazani, Ali; Conde, João; Danafar, Hossein

doi:10.1016/j.bioadv.2022.213090

Cited by 32 publications

(19 citation statements)

References 68 publications

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“…Live and dead 4T1 cells after application of different treatments were imaged following staining with dyes (Figure d). Calcein-AM dye stains the live cells in green, while PI was used to mark the dead cells in red . The growing intensity of red colored dots signifies a higher rate of cell death, whereas the green color reflects live cells.…”

Section: Resultsmentioning

confidence: 99%

“…Calcein-AM dye stains the live cells in green, while PI was used to mark the dead cells in red. 42 The growing intensity of red colored dots signifies a higher rate of cell death, whereas the green color reflects live cells. In the control group, only green fluorescence was observed, and it is obvious that X-ray irradiation alone had little killing effect (little red spots detected) on 4T1 cells in the absence of NP treatment.…”

Section: Resultsmentioning

confidence: 99%

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Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles

Nosrati

Salehiabar

Charmi

et al. 2023

ACS Appl. Bio Mater.

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Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation therapy can be made further effective by utilizing nanoparticles of high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose of maximizing the radiation therapy within tumors, bovine serum albumin capped gadolinium oxide and gold nanoparticles (Gd 2 O 3 @BSA-Au NPs) are developed as a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au and Gd, in a single nanoplatform. The radiosensitizing ability of the nanoparticles was assessed with a series of in vitro tests, following evaluation in vivo in a breast cancer murine model. Enhanced tumor suppression is observed in the group that received radiation after administration of Gd 2 O 3 @BSA-Au NPs. As a result, cancer therapy efficacy is significantly improved by applying Gd 2 O 3 @BSA-Au NPs under X-ray irradiation, as evidenced by studies evaluating cell viability, proliferation, reactive oxygen species production, and in vivo anti-tumor effect.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles

Nosrati

Salehiabar

Charmi

et al. 2023

ACS Appl. Bio Mater.

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“…This confirms the previous findings in the literature, for example, Nosrati et al prepared bimetallic nanoplatforms based on magnetite and bismuth sulfide elements decorated with folic acid for enhanced in vivo chemotherapy. It was found that the hemolysis of the fabricated nanoplatforms at the maximum concentration of the tested materials did not exceed 4%, which lends support to our findings …”

Section: Resultsmentioning

confidence: 99%

“…Apoptosis induction was performed for the synthesized nanoformulations using a flow cytometer (BD FACS Via flow cytometry system) according to the reported methods. , In this regard, first, BT-474 cells were fixed with paraformaldehyde for 15 min and after washing with PBS collected with centrifugation (1200 rpm, 4 °C). In the next step, the cells were incubated with proteinase k (10 min, 37 °C), washed with PBS, and centrifuged (1200 rpm, 4 °C).…”

Section: Methodsmentioning

confidence: 99%

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Hasani

Jafari

Javar

et al. 2023

ACS Appl. Bio Mater.

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Although chemotherapy is regarded as an essential option in cancer treatment, it is still far from being perfect. Inadequate tumor drug concentration and systemic toxicity along with broad biodistribution have diminished the utility of chemotherapy. Tumor-targeting peptide-conjugated multifunctional nanoplatforms have emerged as an effective strategy for site-directed tumor tissues in cancer treatment and imaging. Herein, Pep42-targeted iron oxide magnetic nanoparticles (IONPs) functionalized with β-cyclodextrin (ßCD) containing doxorubicin (DOX) (Fe3O4-ßCD-Pep42-DOX) were successfully developed. The physical effects of the prepared NPs were characterized by employing various techniques. Transmission electron microscopy (TEM) images disclosed that the developed Fe3O4-ßCD-Pep42-DOX nanoplatforms had a spherical morphology and a core–shell structure with a size of nearly 17 nm. Fourier transform infrared (FT-IR) spectroscopy showed that β-cyclodextrin, DOX, and Pep42 molecules were successfully loaded on the IONPs. In vitro cytotoxicity analysis revealed that the fabricated multifunctional Fe3O4-ßCD-Pep42 nanoplatforms possessed excellent biosafety toward BT-474, MDA-MB468 (cancerous cells), and MCF10A normal cells, while Fe3O4-ßCD-Pep42-DOX exhibited great cancer cell killing ability. The high cellular uptake along with intracellular trafficking of Fe3O4-ßCD-Pep42-DOX highlights the usefulness of the Pep42-targeting peptide. In vivo results strongly supported the in vitro results, i.e., significant tumor size reduction was observed by single-dose injection of Fe3O4-ßCD-Pep42-DOX into tumor-bearing mice. Interestingly, in vivo MR imaging (MRI) of Fe3O4-ßCD-Pep42-DOX revealed T 2 contrast improvement in the tumor cells and therapeutic ability in cancer theranostics. Taken together, these findings provided strong evidence for the potential capability of Fe3O4-ßCD-Pep42-DOX as a multifunctional nanoplatform in cancer therapy and imaging and opens up a new avenue of research in this area.

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“…Cancer treatment options include a wide variety of approaches and often include a combination of chemotherapy, surgery, radiotherapy, phototherapy, and immunotherapy with advances being made in combinatorial strategies as hybrid technologies. 137,138 Yet, there is no panacea and the limitations of conventional methods related to therapeutic performance, tumor targeting specificity and off-target toxicities are being addressed by modification of nanosized drug delivery systems.…”

Section: Cancer Therapymentioning

confidence: 99%

Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications

Jan

Madni

Khan

et al. 2022

Bioengineering & Transla Med

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Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability for sustained and controlled drug release. To prolong NP circulation time, enable target-specific drug delivery and overcome physiological barriers, NPs camouflaged in cell membranes have been developed and evaluated to improve drug delivery. Here, we discuss recent advances in cell membrane-coated PLGA NPs, their preparation methods, and their application to cancer therapy, management of inflammation, treatment of cardiovascular disease and control of infection. We address the current challenges and highlight future research directions needed for effective use of cell membranecamouflaged NPs.

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Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

Cited by 32 publications

References 68 publications

Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles

Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications

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