Magnetisation transfer ratio of choline is reduced following epileptic seizures

Flügel, Dominique; Simister, Robert; Duncan, John S.

doi:10.1002/nbm.1023

Cited by 13 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although these studies found both elevated and reduced mI concentrations , there are explanations for the contradictory results. Diminished mI has been reported in medicated patients with, for example, valproate and carbamazepine, and elevated mI has been found in unmedicated patients, suggesting that patients may have elevated pretreatment mI . In addition, an animal study showed that antiepileptic medication (valproate) decreases mI concentration in rat brains .…”

Section: Discussionmentioning

confidence: 99%

“…In particular, abnormal mI concentrations were found in different forms of epilepsy and in patients with autism spectrum disorders . Furthermore, studies have shown that antiepileptic medication has an influence on inositol biosynthesis and mI metabolism in patients with epilepsy , and SCN1A polymorphism has an influence on the medication doses used in this disease . This suggests a direct link between SCN1A and mI concentration.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of normal aging and SCN1A risk‐gene expression on brain metabolites: evidence for an association between SCN1A and myo‐inositol

et al. 2013

View full text Add to dashboard Cite

Previously reported MRS findings in the aging brain include lower N-acetylaspartate (NAA) and higher myo-inositol (mI), total creatine (Cr) and choline-containing compound (Cho) concentrations. Alterations in the sodium channel voltage gated type I, alpha subunit SCN1A variant rs10930201 have been reported to be associated with several neurological disorders with cognitive deficits. MRS studies in SCN1A-related diseases have reported striking differences in the mI concentrations between patients and controls. In a study on 'healthy aging', we investigated metabolite spectra in a sample of 83 healthy volunteers and determined their age dependence. We also investigated a potential link between SCN1A and mI. We observed a significantly negative association of NAA (p = 0.004) and significantly positive associations of mI (p ≤ 0.001), Cr (p ≤ 0.001) and Cho (p = 0.034) with age in frontal white matter. The linear association of Cho ends at the age of about 50 years and is followed by an inverted 'U'-shaped curve. Further, mI was higher in C allele carriers of the SCN1A variant rs10930201. Our results corroborated the age-related changes in metabolite concentrations, and found evidence for a link between SCN1A and frontal white matter mI in healthy subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of normal aging and SCN1A risk‐gene expression on brain metabolites: evidence for an association between SCN1A and myo‐inositol

et al. 2013

View full text Add to dashboard Cite

show abstract

“…For patient studies, single voxels should yield more reliable results. For example, we recently demonstrated a significant reduction in the MTR of Cho following epileptic seizures using such a single‐voxel approach (21).…”

Section: Discussionmentioning

confidence: 99%

Concentrations and magnetization transfer ratios of metabolites in gray and white matter

McLean

Barker

2006

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

The concentrations and magnetization transfer ratios (MTRs) in gray matter (GM) and white matter (WM) of N-acetyl aspartate (NAA), creatine (Cr), choline (Cho), myo-inositol (Ins), and glutamate plus glutamine (Glx) were investigated using magnetic resonance spectroscopic imaging (MRSI). The macromolecule (MM) baseline was studied separately using a metabolite-nulling inversion. Three data sets were collected from a pointresolved spectroscopy (PRESS)-selected volume (TE/TR ‫؍‬ 30/ 3000 ms) of human frontal lobe in vivo: one with MT pulses applied, one with an inversion pulse to null small metabolites, and one with no inversion or MT pulses. The MM signal, which was analyzed by integrating the metabolite-nulled spectrum between 0 and 3 ppm, was estimated to be 38% higher in GM than in WM. MM subtraction decreased the signal-to-noise ratio (SNR) and also decreased the reliability of LCModel quantification of most metabolites, but may have improved the accuracy of quantification of Glx. Glx and Cr were both found to correlate strongly with the GM volume fraction of the voxels. Cr showed the highest MTR, but the other metabolites also showed some attenuation of signal when the MT pulses were applied. With the use of magnetic resonance spectroscopic imaging (MRSI), many groups have shown that metabolite concentrations differ between gray matter (GM) and white matter (WM) (1-6). This difference is most marked for glutamate (2,6) or glutamateϩglutamine (Glx) (4). However, the quantification of Glx is often hampered by the contribution of macromolecule (MM) resonances at the same frequencies to the signal detected.The distribution of MM between WM and GM has been studied less extensively, and with conflicting results. One MRSI study conducted at 2T suggested there was little or no difference in MM signal between GM and WM (7), while two more recent studies using single voxels at 1.5T suggested that MM signal may be greater in GM than in WM (8,9).One method of discriminating between MMs and small metabolites is to precede the acquisition with an inversion pulse, with an inversion time chosen to null the signal from small more mobile metabolites (10). The resultant MM spectrum can then be examined to gain insight into the macromolecular makeup of the cells, and can also be subtracted from an otherwise identical spectrum collected without the inversion pulse to yield a spectrum of small metabolites with reduced effects of MM contamination.It would be helpful to be able to characterize not only the concentration of metabolites in different tissues, but also their local cellular environment. As MRI contrasts based on the magnetization transfer (MT) and diffusion of water have proven useful, interest in gaining similar information about the MT and diffusion of metabolites is increasing. Most metabolite signals have been shown to undergo a small attenuation following the application of MT presaturation pulses (11,12). The relative size of this effect in GM and WM has not been investigated previously.In the current study we use...

show abstract

“…On the other hand, the literature has usually suggested 1 H-MRS as a supplementary tool in the interictal localization of seizure foci. In six studies the possible role of this modality was studied in the ictal and postictal phases [42][43][44][45][46][47]. F. Fadaie et al showed significant decreases in the NAA/Cr, NAA/Cho, and NAA/Cr+Cho ratios immediately after ictus in the ipsilateral hippocampus compared with the contralateral hippocampus of patients and controls.…”

Section: Methodological Review Of Hippocampal 1 H-mrs Studies In Tlementioning

confidence: 99%

The Use of Proton MR Spectroscopy in Epilepsy: A Methodological Review

Mobarakeh¹,

Fadaie²,

Nazem-Zadeh³

et al. 2019

fbt

View full text Add to dashboard Cite

Magnetic Resonance Spectroscopy (MRS) has at least two major roles in the evaluation of epileptic patients. First, MRS can help to understand the interaction between seizures and metabolic function. Thus, MRS is particularly interesting for basic science studies of seizures and epilepsy. Second, MRS can explain the nature of seizure control and/or provide localization information by measuring metabolic changes. So MRS can be used as a powerful complementary technique to structural MRI for diagnosis and assessment of response to therapy, and measurement of disease progression. The aim of this paper is to review the methodological aspects of 1H-MRS publications between 1994 to 2016, which utilized 1H-MRS in lateralizing the epileptogenic zone in lesional and non-lesional Temporal Lobe Epilepsy (TLE), Extra-Temporal Lobe Epilepsy (ETLE), and generalized epileptic patients to help the spectroscopist, magnetic resonance imaging technologists, and radiologists to improve the overall diagnostic sensitivity in epileptic patients.

show abstract

Magnetisation transfer ratio of choline is reduced following epileptic seizures

Cited by 13 publications

References 30 publications

Effects of normal aging and SCN1A risk‐gene expression on brain metabolites: evidence for an association between SCN1A and myo‐inositol

Effects of normal aging and SCN1A risk‐gene expression on brain metabolites: evidence for an association between SCN1A and myo‐inositol

Concentrations and magnetization transfer ratios of metabolites in gray and white matter

The Use of Proton MR Spectroscopy in Epilepsy: A Methodological Review

Contact Info

Product

Resources

About