Magnetically Vectored Delivery of Cancer Drug Using Remotely On–Off Switchable NanoCapsules

Kong, Seong Deok; Choi, Chulmin; Khamwannah, Jirapon; Jin, Sung‐Ho

doi:10.1109/tmag.2012.2223202

Cited by 15 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hollow silica nanoparticle embedded with Fe3O4 has shown significant suppression of MT2 breast cancer cells and B16/BL6 mouse melanoma cells growth after in vitro radiofrequency-activation. In vivo mouse tumor penetration study using magnetic-guided nanocapsules shows 200 times higher magnetic nanocapsules trapped in the tumor cells [46]. Magnetite cationic liposome has been developed for treatment of osteosarcoma which uses localized hyperthermia.…”

Section: Spions For Hyperthermiamentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Cancer Theranostics

2018

AMSE

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (SPIONs) have found extensive applications in both cancer therapy and diagnosis (theranostics) due to their intrinsic magnetic properties. SPIONs can be applied as contrast agents in magnetic resonance imaging while they are considered as efficacious drug carriers for targeted therapeutic systems as well as hyperthermia therapy. In this article, recent advances in application of SPIONs in the realm of cancer theranostics are reviewed. Moreover, biosafety issues arising from SPION application are briefly mentioned.

show abstract

Section: Spions For Hyperthermiamentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Cancer Theranostics

2018

AMSE

View full text Add to dashboard Cite

show abstract

“…Therefore, in order to assess the magnetic targeting / fixing applicability of magnetic particles, the particles' magnetic moment is more relevant than mass magnetization [45,50]. The magnetic targeting potential of multicore particles, in particular the magnetic moment and magnetic mobility were determined in recent magnetophoresis investigations [45,[50][51][52][53][54] ( Table 1).…”

Section: A N U S C R I P Tmentioning

confidence: 99%

“…Loading of liposomes with iron oxide nanoparticles [97], mostly clusters preformed from aqueous [51] and organic [98] ferrofluids, gives rise to magnetoliposomes with high magnetophoretic mobility and MRI contrast, proved to be very effective in drug and gene delivery into cancer cells in vitro and in vivo. Magnetic nanocapsules containing iron oxide nanoparticles and anticancer drugs have been designed to provide highly magnetic carriers under moderate gradient magnetic fields for tumor penetration, which are responsive to remote RF field for ON-OFF switchable drug release [52]. The encapsulation of hydrophobically coated IONPs from ferrofluids together with camptothecin anticancer drug into PPO block of Pluronic vesicles, provided a scalable continuous manufacturing procedure to obtain multi-core theranostic drug delivery vehicles [99], which is a promising step in consolidating recent achievements in targeted drug delivery to cancer cells.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

Tombácz

Turcu

Socoliuc

et al. 2015

Biochemical and Biophysical Research Communications

140

View full text Add to dashboard Cite

“…The drug release was triggered by remotely applying magnetic field which caused heat generation inside magnetite nanoparticles and increased drug diffusivity (Kong et al, 2013).…”

Section: Integration Of Membrane Emulsification and Mini-emulsion Polmentioning

confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

show abstract

Magnetically Vectored Delivery of Cancer Drug Using Remotely On–Off Switchable NanoCapsules

Cited by 15 publications

References 14 publications

Superparamagnetic Iron Oxide Nanoparticles in Cancer Theranostics

Superparamagnetic Iron Oxide Nanoparticles in Cancer Theranostics

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

Structured microparticles with tailored properties produced by membrane emulsification

Contact Info

Product

Resources

About