Magnetically responsive microparticles for targeted drug and radionuclide delivery.

Kamiński, Michał; Ghebremeskel, Alazar N.; Núñez, Luis; Kasza, Karen E.; Chang, Fu Chin; Chien, T.-H.; Fisher, Paula; Rosengart, Axel J.; McDonald, L.; Xie, Yiyang; Johns, L.; Pytel, Peter; Häfeli, Urs O.

doi:10.2172/822552

Cited by 3 publications

(3 citation statements)

References 79 publications

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“…In these studies, in which animals received microparticles through the gastrointestinal tract, it is impossible to determine whether all microparticles in the intestinal epithelium were in the process of internalization or some of them were excreted from the body. In turn, in studies of the biodistribution of microparticles injected intravenously or intraperitoneally, researchers, as a rule, focus on other organs, but not the intestine ( Kaminski et al, 2004 ; Decuzzi et al., 2010 ), or available studies are not detailed enough ( Bartholdson et al, 1977 ; Westrøm et al., 2018 ). Therefore, further research could clarify the specificity and effectiveness of observed migration of loaded phagocytes, followed by penetration of the mucosal epithelium and microparticles removal from D. rerio intestine.…”

Section: Resultsmentioning

confidence: 99%

Histopathological analysis of zebrafish after introduction of non-biodegradable polyelectrolyte microcapsules into the circulatory system

Borvinskaya

Gurkov

Shchapova

et al. 2021

PeerJ

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Polyelectrolyte microcapsules are among the most promising carriers of various sensing substances for their application inside the bloodstream of vertebrates. The long-term effects of biodegradable microcapsules in mammals are relatively well studied, but this is not the case for non-biodegradable microcapsules, which may be even more generally applicable for physiological measurements. In the current study, we introduced non-biodegradable polyelectrolyte microcapsules coated with polyethylene glycol (PMs-PEG) into the circulatory system of zebrafish to assess their long-term effects on fish internal organs with histopathologic analysis. Implantation of PMs-PEG was not associated with the formation of microclots or thrombi in thin capillaries; thus, the applied microcapsules had a low aggregation capacity. The progression of the immune response to the implant depended on the time and the abundance of microparticles in the tissues. We showed that inflammation originated from recognition and internalization of PMs-PEG by phagocytes. These microcapsule-filled immune cells have been found to migrate through the intestinal wall into the lumen, demonstrating a possible mechanism for partial microparticle elimination from fish. The observed tissue immune response to PMs-PEG was local, without a systemic effect on the fish morphology. The most pronounced chronic severe inflammatory reaction was observed near the injection site in renal parenchyma and within the abdominal cavity since PMs-PEG were administered with kidney injection. Blood clots and granulomatosis were noted at the injection site but were not found in the kidneys outside the injection site. Single microcapsules brought by blood into distal organs did not have a noticeable effect on the surrounding tissues. The severity of noted pathologies of the gills was insufficient to affect respiration. No statistically significant alterations in hepatic morphology were revealed after PMs-PEG introduction into fish body. Overall, our data demonstrate that despite they are immunogenic, non-biodegradable PMs-PEG have low potential to cause systemic effects if applied in the minimal amount necessary for detection of fluorescent signal from the microcapsules.

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Section: Resultsmentioning

confidence: 99%

Histopathological analysis of zebrafish after introduction of non-biodegradable polyelectrolyte microcapsules into the circulatory system

Borvinskaya

Gurkov

Shchapova

et al. 2021

PeerJ

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“…Furlani and Furlani [1,2,3] presented an analytical model for transport and capture of therapeutic magnetic nanoparticles in the human vasculature for targeted drug delivery applications. A wide range of approaches in design and implementation of magnetic particle based drug delivery system to date is given by M. D Kaminski et al [4]. Theoritical analysis of applications of magnetic nanoparticles and micro particles into the lung epithelium was studied by P. Babinec et al [5].…”

Section: Prior Workmentioning

confidence: 99%

Mathematical Modelling of Drug Targeting Using Computational Methods

Uthra

Vasanthakumari

2015

BJMCS

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Magnetic nanoparticles play a crucial role as drug carriers in the human body. In this investigation the particle movement is analysed knowing the local flow condition and using appropriate magnets. The particles are injected into the vascular system upstream from malignant tissue and captured at the tumor using an applied magnetic field. The applied field was obtained by using a quadrupole magnet that couples to the magnetic nanoparticles inside the carrier particle and produces a force that attracts the particle to the tumor. The flux density components of the quadrupole magnet is calculated using Scilab. This study also provides a mathematical model (I) needed for the development of drug targeting to the lungs in comparison with experimental results. The trajectories of magnetite particles of different sizes in the field of permanent quadrupole in the air and water were traced in different times with the help of numerical solver. It was found that the tendency of the particle to be captured by the magnet increases when air is chosen as the medium.In the Investigation of model (II) the behavior of blood was considered as Hershel-bulkley fluid which is suitable for the micro vessel of radius 50 nm. Analytical expression was derived for predicting the volume fraction of embedded magnetic nanoparticles required to capture the carrier particle at the tumor. A parametric analysis of magnetic targeting as a function of key variables including the size of the carrier particle and volume fraction is made. The assumptions to the model was made by comparing with the theoretical model done earlier [9] and implemented using mathematical software scilab 5.4.

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“…Several articles have been devoted to a summary of the application of drug-loaded spheres [24][25][26][27], magnetic carrier technology [28], and technology status with magnetic targeting of magnetic carriers [29]. Several articles have been devoted to a summary of the application of drug-loaded spheres [24][25][26][27], magnetic carrier technology [28], and technology status with magnetic targeting of magnetic carriers [29].…”

Section: Development Of Biostabilized Magnetic Nanospheresmentioning

confidence: 99%