2023
DOI: 10.1021/acsomega.3c00886
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Magnetically Powered Chitosan Milliwheels for Rapid Translation, Barrier Function Rescue, and Delivery of Therapeutic Proteins to the Inflamed Gut Epithelium

Abstract: Inflammatory bowel disease (IBD) is mediated by an overexpression of tumor necrosis factor-α (TNF) by mononuclear cells in the intestinal mucosa. Intravenous delivery of neutralizing anti-TNF antibodies can cause systemic immunosuppression, and up to one-third of people are non-responsive to treatment. Oral delivery of anti-TNF could reduce adverse effects; however, it is hampered by antibody degradation in the harsh gut environment during transit and poor bioavailability. To overcome these shortcomings, we de… Show more

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Cited by 3 publications
(1 citation statement)
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“…Multiple publications that make use of tools in MicroTracker.jl are available, each unique in their scientific contribution and independent of this package. These include studies of microbots for use in the vasculature(C. J. , lungs(Coy J. , gastrointestinal system (Osmond et al, 2023), and at the air water interface (Wolvington et al, 2023).…”
Section: Statement Of Needmentioning
confidence: 99%
“…Multiple publications that make use of tools in MicroTracker.jl are available, each unique in their scientific contribution and independent of this package. These include studies of microbots for use in the vasculature(C. J. , lungs(Coy J. , gastrointestinal system (Osmond et al, 2023), and at the air water interface (Wolvington et al, 2023).…”
Section: Statement Of Needmentioning
confidence: 99%