Magnetically agitated continuous-flow tube reactors with aspartate ammonia-lyase immobilized on magnetic nanoparticles

Abstract

Two magnetically agitated continuous flow tube reactors (AFRs)—applying external permanent magnets to move magnetic nanoparticles coated with biocatalyst within a stream of the reaction medium—were developed and studied with the...

Immobilization of Lipase B from Candida antarctica on Magnetic Nanoparticles Enhances Its Selectivity in Kinetic Resolutions of Chiral Amines with Several Acylating Agents

“…However, other types of MNP-based flow reactors offer the possibility of larger enhancement, which could be the subject of further studies. In a recent study on agitated MNP-based flow reactors, where different types of continuous-flow reactors were compared, including a cell corresponding to a cell of the U-shape reactor used in this work, the U b value in a magnetically fixed cell could be enhanced further by three to four times in an agitated MNP flow reactor cell with rotational movement of two magnets (AFR RM ) [46]. This enhancement of up to fourfold, achievable only with MNP-bound forms, significantly exceeds the maximum twofold enhancement found thus far in PBRs as compared to batch reactions.…”