Magnetically Actuated Droplet Manipulation and Its Potential Biomedical Applications

Huang, Guangsu; Li, Moxiao; Yang, Qingzhen; Li, Yuhui; Líu, Hao; Yang, Hui; Xu, Feng

doi:10.1021/acsami.6b09017

Cited by 124 publications

(86 citation statements)

References 154 publications

(240 reference statements)

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“…Compared to other droplet manipulation methods, magnetic actuation possesses distinct virtues, such as heatless generation, easy operation and noncontact to sample. Furthermore, environmental parameters, such as temperature, ion concentration and pH, are hardly influence the magnetic fields and the magnet forces . Our group first demonstrated the generation and deflection of magnetically functionalized droplets (Figure B) .…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 89%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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109

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 89%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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109

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“…In the following 20 years, magnetic microfluidic systems have developed rapidly and are regarded as an indispensable branch of microfluidics now. Same as traditional microfluidics, magnetic microfluidics could be divided into continuous‐flow and digital magnetic microfluidics, both of which harness magnetic fields as actuators and magnetic materials as driven objects. Magnetic microfluidics not only inherits systematic precise control over individual fluid and droplet of traditional microfluidics, but also is characterized by simple actuation strategy, flexible controllability, remote operation, as well as noninvasive manipulation ability .…”

Section: Ferrofluid‐assisted Fluid and Droplet Manipulationmentioning

confidence: 99%

“…Magnetic microfluidics not only inherits systematic precise control over individual fluid and droplet of traditional microfluidics, but also is characterized by simple actuation strategy, flexible controllability, remote operation, as well as noninvasive manipulation ability . Thanks to these superior advantages, magnetic microfluidics is playing a vital role in biomolecule delivery, chemical reactions, bioseparation, polymerase chain reaction (PCR), and many other applications …”

Section: Ferrofluid‐assisted Fluid and Droplet Manipulationmentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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“…Recently, magnetic tweezers and micromagnetophoretic patterns offer significant advancements by overcoming the abovementioned complications toward precise particle, droplet, and cell manipulations. Furthermore, we have demonstrated a class of integrated circuits of micromagnetophoretic patterns, such as conductors, diodes, capacitors, and transistors to execute sequential and parallel operations on an ensemble of single particles and cells .…”

Section: Multifarious Transit Gating Of Particles Moving Along the Rementioning

confidence: 99%

Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters

Torati

Kim

et al. 2019

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Programmable delivery of biological matter is indispensable for the massive arrays of individual objects in biochemical and biomedical applications. Although a digital manipulation of single cells has been implemented by the integrated circuits of micromagnetophoretic patterns with current wires, the complex fabrication process and multiple current operation steps restrict its practical application for biomolecule arrays. Here, a convenient approach using multifarious transit gates is proposed, for digital manipulation of biofunctionalized microrobotic particles that can pass through the local energy barriers by a time‐dependent pulsed magnetic field instead of multiple current wires. The multifarious transit gates including return, delay, and resistance linear gates, as well as dividing, reversed, and rectifying T‐junction gates, are investigated theoretically and experimentally for the programmable manipulation of microrobotic particles. The results demonstrate that, a suitable angle of the gating field at a suitable time zone is crucial to implement digital operations at integrated multifarious transit gates along bifurcation paths to trap microrobotic particles in specific apartments, paving the way for flexible on‐chip arrays of biomolecules and cells.

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Magnetically Actuated Droplet Manipulation and Its Potential Biomedical Applications

Cited by 124 publications

References 154 publications

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Flexible Ferrofluids: Design and Applications

Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters

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