Magnetic vestibular stimulation modulates default mode network fluctuations

Boegle, Rainer; Stephan, Thomas; Ertl, Matthias; Glasauer, Stefan; Dieterich, Marianne

doi:10.1016/j.neuroimage.2015.11.065

Cited by 32 publications

(55 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the MRI system, a robust nystagmus is elicited in vestibularly healthy humans, and the accompanied nystagmus seems to be dependent on the direction and strength of the magnetic field (Ward, Roberts, Della Santina, Carey, & Zee, ). Thus, we argue that conventional fMRI studies concomitant with vestibular activation might be biased by the inherent static magnetic field in the MRI systems, although this hypothesis requires further research (Boegle, Stephan, Ertl, Glasauer, & Dieterich, ). Another potential confounding problem with fMRI studies in this research area is the auditory stimulus produced by the gradients coils during fMRI acquisition.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus

Devantier

Hansen

Mølby-Henriksen

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

The existence of a human primary vestibular cortex is still debated. Current knowledge mainly derives from functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) acquisitions during artificial vestibular stimulation. This may be problematic as artificial vestibular stimulation entails coactivation of other sensory receptors. The use of fMRI is challenging as the strong magnetic field and loud noise during MRI may both stimulate the vestibular organ. This study aimed to characterize the cortical activity during natural stimulation of the human vestibular organ. Two fluorodeoxyglucose (FDG)‐PET scans were obtained after natural vestibular stimulation in a self‐propelled chair. Two types of stimuli were applied: (a) rotation (horizontal semicircular canal) and (b) linear sideways movement (utriculus). A comparable baseline FDG‐PET scan was obtained after sitting motion‐less in the chair. In both stimulation paradigms, significantly increased FDG uptake was measured bilaterally in the medial part of Heschl's gyrus, with some overlap into the posterior insula. This is the first neuroimaging study to visualize cortical processing of natural vestibular stimuli. FDG uptake was demonstrated in the medial‐most part of Heschl's gyrus, normally associated with the primary auditory cortex. This anatomical localization seems plausible, considering that the labyrinth contains both the vestibular organ and the cochlea.

show abstract

Section: Discussionmentioning

confidence: 92%

“…To our knowledge, previous neuroimaging studies in humans have all employed artificial stimulation paradigms without any physical head motion for studying vestibular function. (Boegle, Stephan, Ertl, Glasauer, & Dieterich, 2016).…”

Section: Discussionmentioning

confidence: 99%

Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus

Devantier

Hansen

Mølby-Henriksen

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…This cannot be achieved with other vestibular stimuli and allows one to investigate the multiple timescales of adaptation to a sustained, unwanted vestibular imbalance. Combined with MRI imaging, MVS might reveal the anatomical substrate and changes in default networks that underlie vestibular adaptation [8]. Finally, MVS might be used in rehabilitation in set-point adaptation diseases by inducing a new bias to counteract a pathological one.…”

Section: Discussionmentioning

confidence: 99%

“…We propose a new adaptation hypothesis, using a cascade of imperfect mathematical integrators, that reproduces the response to MVS (and more natural chair rotations), including the gradual decrease in nystagmus as the set point changes over progressively longer time courses. MVS set-point adaptation is a biological model with applications to basic neurophysiological research into all types of movements [7], functional brain imaging [8], and treatment of vestibular and higher-level attentional disorders by introducing new biases to counteract pathological ones [9]. …”

mentioning

confidence: 99%

Multiple Time Courses of Vestibular Set-Point Adaptation Revealed by Sustained Magnetic Field Stimulation of the Labyrinth

et al. 2016

View full text Add to dashboard Cite

SUMMARY A major focus in neurobiology is how the brain adapts its motor behavior to changes in its internal and external environments [1, 2]. Much is known about adaptively optimizing the amplitude and direction of eye and limb movements, for example, but little is known about another essential form of learning, “set-point” adaptation. Set-point adaptation balances tonic activity so that reciprocally acting, agonist and antagonist muscles have a stable platform from which to launch accurate movements. Here, we use the vestibulo-ocular reflex—a simple behavior that stabilizes the position of the eye while the head is moving—to investigate how tonic activity is adapted toward a new set point to prevent eye drift when the head is still [3, 4]. Set-point adaptation was elicited with magneto-hydrodynamic vestibular stimulation (MVS) by placing normal humans in a 7T MRI for 90 min. MVS is ideal for prolonged labyrinthine activation because it mimics constant head acceleration and induces a sustained nystagmus similar to natural vestibular lesions [5, 6]. The MVS-induced nystagmus diminished slowly but incompletely over multiple timescales. We propose a new adaptation hypothesis, using a cascade of imperfect mathematical integrators, that reproduces the response to MVS (and more natural chair rotations), including the gradual decrease in nystagmus as the set point changes over progressively longer time courses. MVS set-point adaptation is a biological model with applications to basic neurophysiological research into all types of movements [7], functional brain imaging [8], and treatment of vestibular and higher-level attentional disorders by introducing new biases to counteract pathological ones [9].

show abstract

“…On the caveat side, any induced nystagmus, whether or not it is suppressed by fixation, will be accompanied by dramatic changes in activity in many parts of the brain due to the widespread projections of information emanating from the labyrinth. Such metabolic activity could be an important confound in interpreting fMRI studies (32, 33) as well as the fact that vestibular activation of MVS is subject to adaptive mechanisms that try and eliminate it. Positioning the head in the null position might eliminate the MVS effect.…”

Section: Further Implications and Future Directions Of Mvsmentioning

confidence: 99%

Magnetic Vestibular Stimulation (MVS) As a Technique for Understanding the Normal and Diseased Labyrinth

et al. 2017

View full text Add to dashboard Cite

Humans often experience dizziness and vertigo around strong static magnetic fields such as those present in an MRI scanner. Recent evidence supports the idea that this effect is the result of inner ear vestibular stimulation and that the mechanism is a magnetohydrodynamic force (Lorentz force) that is generated by the interactions between normal ionic currents in the inner ear endolymph and the strong static magnetic field of MRI machines. While in the MRI, the Lorentz force displaces the cupula of the lateral and anterior semicircular canals, as if the head was rotating with a constant acceleration. If a human subject’s eye movements are recorded when they are in darkness in an MRI machine (i.e., without fixation), there is a persistent nystagmus that diminishes but does not completely disappear over time. When the person exits the magnetic field, there is a transient aftereffect (nystagmus beating in the opposite direction) that reflects adaptation that occurred in the MRI. This magnetic vestibular stimulation (MVS) is a useful technique for exploring set-point adaptation, the process by which the brain adapts to a change in its environment, which in this case is vestibular imbalance. Here, we review the mechanism of MVS, how MVS produces a unique stimulus to the labyrinth that allows us to explore set-point adaptation, and how this technique might apply to the understanding and treatment of vestibular and other neurological disorders.

show abstract

Magnetic vestibular stimulation modulates default mode network fluctuations

Cited by 32 publications

References 28 publications

Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus

Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus

Multiple Time Courses of Vestibular Set-Point Adaptation Revealed by Sustained Magnetic Field Stimulation of the Labyrinth

Magnetic Vestibular Stimulation (MVS) As a Technique for Understanding the Normal and Diseased Labyrinth

Contact Info

Product

Resources

About