Magnetic Tracers for Magnetic Particle Imaging: Insight on the Roles of Frequency-Sustained Hysteresis and Interactions in Quantitative Imaging

Barrera, Gabriele; Allia, Paolo; Tiberto, P.

doi:10.1103/physrevapplied.19.034029

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…In applications involving spectral analysis of the magnetic signal, exactly determining the actual dependence of M on the driving field seems to be of lesser importance; however, an imperfect knowledge of the behaviour of M with H can lead to negative consequences. An example of the drawbacks of an ill-defined magnetization curve in the MPI image reconstruction has been recently discussed [29].…”

Section: Introductionmentioning

confidence: 99%

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

Barrera

Tiberto

2023

J. Phys. Mater.

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An innovative method is proposed to determine the most important magnetic properties of bioapplication-oriented magnetic nanomaterials exploiting the connection between hysteresis loop and frequency spectrum of magnetization. Owing to conceptual and practical simplicity, the method may result in a substantial advance in the optimization of magnetic nanomaterials for use in precision medicine. The techniques of frequency analysis of the magnetization currently applied to nanomaterials both in vitro and in vivo usually give a limited, qualitative picture of the effects of the active biological environment on magnetic tracers, and have to be complemented by direct measurement of the hysteresis loop. We show that the very same techniques can be used to convey all the information needed by present-day biomedical applications without the necessity of doing conventional magnetic measurements in the same experimental conditions. The spectral harmonics obtained analyzing the response of a magnetic tracer in frequency, as in Magnetic Particle Spectroscopy/Imaging (MPS/MPI), are demonstrated to lead to a precise reconstruction of the hysteresis loop, whose most important parameters (loop's area, magnetic remanence and coercive field) are directly obtained through transformation formulas based on simple manipulation of the harmonics amplitudes and phases.The validity of the method is experimentally verified on various magnetic nanomaterials for bioapplications submitted to ac magnetic fields of different amplitude, frequency and waveshape. In all cases, the experimental data taken in the frequency domain exactly reproduce the magnetic properties obtained from conventional magnetic measurements.

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Section: Introductionmentioning

confidence: 99%

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

Barrera

Tiberto

2023

J. Phys. Mater.

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Magnetic nanoparticles in square-wave fields for breakthrough performance in hyperthermia and magnetic particle imaging

Barrera,

Allia,

Tiberto

2024

Sci Rep

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Driving immobilized, single-domain magnetic nanoparticles at high frequency by square wave fields instead of sinusoidal waveforms leads to qualitative and quantitative improvements in their performance both as point-like heat sources for magnetic hyperthermia and as sensing elements in frequency-resolved techniques such as magnetic particle imaging and magnetic particle spectroscopy. The time evolution and the frequency spectrum of the cyclic magnetization of magnetite nanoparticles with random easy axes are obtained by means of a rate-equation method able to describe time-dependent effects for the particle sizes and frequencies of interest in most applications to biomedicine. In the presence of a high-frequency square-wave field, the rate equations are shown to admit an analytical solution and the periodic magnetization can be therefore described with accuracy, allowing one to single out effects which take place on different timescales. Magnetic hysteresis effects arising from the specific features of the square-wave driving field results in a breakthrough improvement of both the magnetic power released as heat to an environment in magnetic hyperthermia treatments and the magnitude of the third harmonic of the frequency spectrum of the magnetization, which plays a central role in magnetic particle imaging.

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Magnetic nanoparticle hyperthermia enhanced by a rotating field

Barrera,

Allia,

Tiberto

2024

Phys. Rev. Applied

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Magnetic Tracers for Magnetic Particle Imaging: Insight on the Roles of Frequency-Sustained Hysteresis and Interactions in Quantitative Imaging

Cited by 3 publications

References 74 publications

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

Magnetic nanoparticles in square-wave fields for breakthrough performance in hyperthermia and magnetic particle imaging

Magnetic nanoparticle hyperthermia enhanced by a rotating field

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