Magnetic targeted near-infrared II PA/MR imaging guided photothermal therapy to trigger cancer immunotherapy

Fu, Qinrui; Li, Zhi; Ye, Jiamin; Li, Zhong; Fu, FengFu; Lin, Syue Liang; Chang, C. Allen; Yang, Huanghao; Song, Jibin

doi:10.7150/thno.43604

Cited by 68 publications

(50 citation statements)

References 49 publications

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“…Following laser thermotherapy, there are increased tissue levels of IFN- γ, IL-2 and IL-10 in treated tumors ( 70 ). Following nanoparticle-based photothermal therapy without any adjuvant, CD8 levels were increased in untreated tumors in 2/4 studies ( 71 , 73 – 75 ), and T reg cells increased in untreated tumor in one of two studies ( 71 , 75 ). Combination with checkpoint blockade increased CD8 and lowered T reg cells in these nanoparticle-based studies.…”

Section: Local Tumor Destruction Methodsmentioning

confidence: 99%

“…Rejection immunity was demonstrated in 5/5 studies (64,70,76,77,79). Nanoparticle-based photothermal therapies have been shown to produce abscopal effects in 1/5 studies when used alone (71)(72)(73)(74)(75). An abscopal effect was regularly seen when photothermal therapy was combined with a checkpoint blocker (71)(72)(73)75) and in a study where CpG ODN was incorporated into the nanomaterial (74).…”

Section: Systemic Effectsmentioning

confidence: 99%

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Local Destruction of Tumors and Systemic Immune Effects

Tranberg

2021

Front. Oncol.

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Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable variation between the different techniques with respect to the ability and frequency to create a systemic anti-tumor immunologic effect. Since the abscopal effect is considered to be the best indicator of a relevant immunologic effect, the present review focused on the tissue changes associated with this effect in order to find determinants for a strong immunologic response, both when local destruction is used alone and combined with immunotherapy. In addition to the T cell-inflammation that was induced by all methods, the analysis indicated that it was important for an optimal outcome that the released antigens were not destroyed, tumor cell death was necrotic and tumor tissue perfusion was at least partially preserved allowing for antigen presentation, immune cell trafficking and reduction of hypoxia. Local treatment with controlled low level hyperthermia met these requisites and was especially prone to result in abscopal immune activity on its own.

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Section: Local Tumor Destruction Methodsmentioning

confidence: 99%

Section: Systemic Effectsmentioning

confidence: 99%

Local Destruction of Tumors and Systemic Immune Effects

Tranberg

2021

Front. Oncol.

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“…Similarly, the use of black phosphorus QDs, [54] Prussian blue NPs, [55] and copper sulfide NPs [56] in combination with anti‐PD‐1, anti‐PD‐L1, or anti‐CTLA‐4 antibodies for checkpoint blockade immunotherapy combined with PTT has also been reported. Moreover, due to the increased tissue penetration depth of second‐window NIR light (NIR‐II, 1000–1700 nm), the combination of NIR‐II PTT using polypyrrole NPs [57] and titanium disulfide nanosheets [58] with immune checkpoint blockades was adopted to treat deep‐lying solid tumors. NIR‐II PTT could trigger more homogeneous and deeper ICD induction in solid tumors, thus eliciting strong immune responses after combination with anti‐PD‐1 treatment for tumor rejection and metastasis prevention.…”

Section: Combinational Phototherapy–immunotherapymentioning

confidence: 99%

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Luo

2021

Angew Chem Int Ed

166

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Immunotherapy that harnesses the power of the immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune‐related adverse events exist as two major issues for cancer immunotherapy. In parallel, a variety of electromagnetic nanomaterials that generate heat and/or reactive oxygen species triggered by electromagnetic energy have been applied for magnetic hyperthermia therapy, sonodynamic therapy, photothermal therapy, photodynamic therapy, and radiotherapy, which have the ability to induce immunogenic cell death. This review summarizes the recent development of electromagnetic nanomedicines in combinational cancer immunotherapy. The mechanisms of electromagnetic nanomedicines in reprogramming the immunosuppressive tumor microenvironment and sensitizing tumors for cancer immunotherapy are highlighted. Furthermore, potential challenges and perspectives of electromagnetic nanomedicines for combinational cancer immunotherapy are discussed.

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“…It was observed that an obvious 4T1 tumor growth inhibition could be achieved by combining PTT with anticytotoxic T-lymphocyte antigen-4 (CTLA-4) immunotherapy, offering a new therapeutic approach to overcome Treg-mediated immunosuppression and amplify the effect of cancer immunotherapy. Similarly, Fu et al [70] developed a kind of IONPs-anchored titanium disulfide (TiS 2 ) nanosheets that resulted in elevated NP accumulation at tumor sites compared to non-treated groups. Moreover, an enhanced population of immune cells with a reduced number of Tregs was observed after the combination treatment with anti-PD-1 and PTT.…”

Section: Iron Oxide-based Nanomaterialsmentioning

confidence: 99%

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

Tang

Zhang

et al. 2022

Cancer Communications

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Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic modality to treat both primary and metastatic tumors. Immunotherapy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination. Phototherapy destroys the primary tumors by light irradiation, which induces a series of immune responses through triggering immunogenic cancer cell death. Therefore, when integrating immunotherapy with phototherapy, a novel anti-cancer strategy called photoimmunotherapy (PIT) is emerging. This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations, opening a new era for the current anti-cancer therapy. Recently, the advancement of nanomaterials affords a platform for PIT. From all these nanomaterials, inorganic nanomaterials stand out as ideal mediators in PIT due to their unique physiochemical properties. Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photothermal agents or photosensitizers in phototherapy because of their great optical characteristics. In this review, the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted.

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Magnetic targeted near-infrared II PA/MR imaging guided photothermal therapy to trigger cancer immunotherapy

Cited by 68 publications

References 49 publications

Local Destruction of Tumors and Systemic Immune Effects

Local Destruction of Tumors and Systemic Immune Effects

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Multifunctional inorganic nanomaterials for cancer photoimmunotherapy

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