Magnetic stimulation of carotid sinus as a treatment for hypertension

Li, Rongrong; Dai, Zhengze; Ye, Richard D.; Liu, Xinfeng; Xia, Zhengkun; Xu, Gelin

doi:10.1111/jch.13470

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Recently discovered time-varying electromagnetic fields stimulatory effects on arterial baroreceptors in rabbits and healthy individuals [Zhang et al, 2017;Li et al, 2019] supported presented results, suggesting mechano/baroreceptor activation to be the general feature and the mechanism of the different magnetic fields interaction with cardiovascular system in laboratory animals and humans [Gmitrov, 1996[Gmitrov, , 2015[Gmitrov, , 2020.…”

Section: Smf Blood Pressure Bu¡ering Mechanisms and Implicationssupporting

confidence: 72%

Carotid Baroreceptor Magnetic Activation and Beat‐to‐Beat Blood Pressure Variability, Implications to Treat Abrupt Blood Pressure Elevation in Labile Hypertension

Gmitrov

2022

Bioelectromagnetics

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Mounting evidence suggests enhanced blood pressure (BP) variability (BPV) independent role in cardiovascular (CV) damage. The goal was to estimate the effect of the carotid baroreceptor (CB) magnetic stimulation on sudden high BP elevation. Mean femoral arterial BP (MAP), heart rate (HR), baroreflex sensitivity (BRS), and ear lobe skin microcirculatory blood flow, by microphotoelectric plethysmography (MPPG), were simultaneously recorded in conscious rabbits sedated by pentobarbital intravenous (i.v.) infusion (5 mg/kg/h) after 40 min CB exposure to 350 mT static magnetic field (SMF), by Nd 2 -Fe 14 -B magnets (n = 14), or sham magnets exposure (n = 14). BRS was assessed from HR and MAP responses to abrupt hypotension induced by i.v. bolus injections of nitroprusside (Ni) and abrupt MAP elevation (MAP AE ) by i.v. bolus of phenylephrine (Ph). Beat-tobeat BPV was estimated by MAP standard deviation. SMF CB exposure significantly increased BRS Ni (74.5 ± 17.8%, P < 0.001) and microcirculation (23.8% ± 11.0%, P = 0.039); decreased MAP (−5.7 ± 1.7%, P < 0.014) and phenylephrine-induced MAP AE (−19.1%, P = 0.043). MAP AE positively correlated with resting MAP (r = 0.342, P = 0.0383) and MAP SD (r = 0.383, P = 0.0194), and inversely with BRS Ph (r = −0.47, P = 0.0156). SMF CB exposure enhanced the nitroprusside, which acts by releasing nitric oxide (NO), vasodilatory effect. This indicates arterial baroreflex to improve vessel sensitivity to NO, which is a new physiology with BP buffering effect. A positive correlation of MAP SD to phenylephrine BP ramps suggests a causal relationship and BPV prognostic significance to forecast abrupt BP elevation. Mechano/baroreceptor magnetosensing property proposed to be the basic physiology by which SMFs boost CV autonomic regulation with potential implementation in high CV risk labile arterial hypertensive disease. Bioelectromagnetics. 43:413-425, 2022.

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Section: Smf Blood Pressure Bu¡ering Mechanisms and Implicationssupporting

confidence: 72%

Carotid Baroreceptor Magnetic Activation and Beat‐to‐Beat Blood Pressure Variability, Implications to Treat Abrupt Blood Pressure Elevation in Labile Hypertension

Gmitrov

2022

Bioelectromagnetics

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Theta burst stimulation over the prefrontal cortex: Effects on cerebral oximetry and cardiovascular measures in healthy humans

Pinto

Gonçalves

Silva

et al. 2021

Neuroscience Letters

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Electromagnetic field and cardiovascular diseases: A state‐of‐the‐art review of diagnostic, therapeutic, and predictive values

Wang,

Zhao,

Chai

et al. 2023

The FASEB Journal

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Despite encouraging advances in early diagnosis and treatment, cardiovascular diseases (CVDs) remained a leading cause of morbidity and mortality worldwide. Increasing evidence has shown that the electromagnetic field (EMF) influences many biological processes, which has attracted much attention for its potential therapeutic and diagnostic modalities in multiple diseases, such as musculoskeletal disorders and neurodegenerative diseases. Nonionizing EMF has been studied as a therapeutic or diagnostic tool in CVDs. In this review, we summarize the current literature ranging from in vitro to clinical studies focusing on the therapeutic potential (external EMF) and diagnostic potential (internal EMF generated from the heart) of EMF in CVDs. First, we provided an overview of the therapeutic potential of EMF and associated mechanisms in the context of CVDs, including cardiac arrhythmia, myocardial ischemia, atherosclerosis, and hypertension. Furthermore, we investigated the diagnostic and predictive value of magnetocardiography in CVDs. Finally, we discussed the critical steps necessary to translate this promising approach into clinical practice.

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Magnetic stimulation of carotid sinus as a treatment for hypertension

Cited by 4 publications

References 23 publications

Carotid Baroreceptor Magnetic Activation and Beat‐to‐Beat Blood Pressure Variability, Implications to Treat Abrupt Blood Pressure Elevation in Labile Hypertension

Carotid Baroreceptor Magnetic Activation and Beat‐to‐Beat Blood Pressure Variability, Implications to Treat Abrupt Blood Pressure Elevation in Labile Hypertension

Theta burst stimulation over the prefrontal cortex: Effects on cerebral oximetry and cardiovascular measures in healthy humans

Electromagnetic field and cardiovascular diseases: A state‐of‐the‐art review of diagnostic, therapeutic, and predictive values

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