Magnetic Solid Sulfonic Acid Decorated with Hydrophobic Regulators: A Combinatorial and Magnetically Separable Catalyst for the Synthesis of α-Aminonitriles

Abstract

A three-component, Strecker reaction of a series of aldehydes or ketones, amines, and trimethylsilyl cyanide for the synthesis of α-aminonitriles in the presence of a catalytic amount of a magnetic solid sulfonic acid catalyst, Fe3O4@SiO2@Me&Et-PhSO3H under solvent-free conditions have been investigated. This catalyst, with a combination of hydrophobicity and acidity on the Fe3O4@SiO2 core-shell of the magnetic nanobeads, as well as its water-resistant property, enabled easy mass transfer and catalytic activity in the Strecker reaction. The catalyst was easily separated by an external magnet and the recovered catalyst was reused in 6 successive reaction cycles without any significant loss of activity.

Meglumine Promoted Strategy: Environmentally Benign Protocol towards the Synthesis of Polysubstituted 2‐Aminopyrroles in Aqueous Condition

“…Recently, multi‐component reactions (MCRs) has grab considerable attention because it's efficient access to highly complex final products in a single step ,. MCRs have proven to be more powerful and superior to classical multistep approaches because it can shorten the reaction time, improve the atom economy, reduce the separation steps, operational simplicity as well as give usual excellent productivity . Moreover, MCRs are environmentally friendly and have simpler and cheaper purification technique .…”

Cu (II)‐β‐cyclodextrin complex stabilized on magnetic nanoparticles: A retrievable hybrid promoter for green synthesis of spiropyrans

“…Among the various MNPs, manganese ferrites (MnFe 2 O 4 ) have attracted special interest due to high saturation, low toxicity, good compatibility and super paramagnetic properties . Surface functionalization of MNPs, which can be performed easily by a variety of acidic or basic organic/inorganic ligands, is a method for preparation of organic–inorganic hybrid materials as heterogeneous catalysts . Cyclodextrins (CDs) are cyclic oligosaccharides, made up from six (α‐CD), seven (β‐CD) or eight (γ‐CD) d ‐glucopyranose units.…”

The solvent‐free synthesis of polysubstituted pyrroles by a reusable copper Schiff base complex immobilized on silica coated Fe3O4, and DNA binding study of one resulting derivative as a potential anticancer drug

“…In contrast, immobilized catalysts on Fe 3 O 4 can be magnetically recoverable from the reaction mixture by an external magnet. Synthesis, characterization and surface modification of nanoparticles with desired properties have attracted growing attention in recent researches …”