Magnetic solid phase extraction of Sunitinib malate in urine samples assisted with mixed hemimicelle and spectrophotometric detection

Abstract

The mixed hemimicelle-based solid phase extraction method using the coated sodium dodecyl sulfate by magnetic iron oxide nanoparticles as adsorbent was developed for extraction and determination of Sunitinib malate in real samples prior to determination by UV–Visible spectrophotometry. For the characterization of synthesized nanoparticles, Fourier transform infrared spectroscopy, and scanning electron microscopy was used. The influences of different factors affecting the extraction efficiency of Sunitinib malate, including the pH, the adsorbent amount, the volume and eluent type, the amount of the surfactant, the ionic strength, extraction, and desorption time, were investigated. At the optimized conditions, a good linearity with correlation coefficients of 0.998 and 0.999 was obtained over the concentration ranges of 1–22 and 1–19 µg/mL for water and urine samples, in order. The good recoveries of 97% and 99% and also, the limits of detection equal with 0.9, and 0.8 µg/mL for water and urine samples were enhanced, respectively. These results demonstrate that mixed hemimicelle solid phase extraction is a fast, efficient, economical and selective sample preparation method for the extraction and determination of Sunitinib malate in different water and urine sample solutions.

Tumor Supplying Artery Injection of Liposome@Sunitinib Could Effectively Inhibit the Progression of Kidney Tumor

“…From the UV−vis spectrum, a distinct absorption peak of sunitinib was detected at approximately 421 nm (Figure S1), which is in agreement with previously described. 28 As in previous studies, 29,30 the peak absorption of sunitinib at 421 nm was used to quantify the sunitinib content to estimate the encapsulation efficacy of liposomes. The results showed that the encapsulation efficacy of liposomes gradually increased with the increasing amount of lipids, and the efficacy seemed to level off when the mass ratio of sunitinib to lipids reached 1:10 (Figure 1g).…”

Fe-Ni@ACC Nanocomposite For Magnetic Dispersive Micro Solid-Phase Extraction Of Cu (II) From Food And Hair Samples

“…[25][26][27] Many sample preparation methods such as solid phase extraction (SPE), liquid-liquid extraction (LLE), and cloud point extraction (CPE) have been developed for separation and enrichment of copper from complex matrix media. [28][29][30][31] However, all these classical methods have initiated to leave their position to microextraction methods because of the disadvantages such as time consuming, laborious, expensive, toxic, insufficient preconcentration factor, high organic solvent volume and secondary waste. [32][33] For these disadvantages to eliminate, microextraction techniques developed such as liquid phase micro extraction (LPME) and magnetic dispersive micro solid-phase extraction (M-D-μSPE), which offer the advantages of environmentally friendly, simple, fast, cheap, high preconcentration factor, high analyte recovery, minimal analyte loss and low volume toxic solvent use.…”

Magnetic Solid‐Phase Extraction of Fipronil from Aqueous Solution and Eggshells Using Amine‐Coated Iron Oxide Nanoparticles

“…Magnetic solid phase extraction enables the removal of adsorbents from the solution by means of magnetic nanoparticles, without the need for centrifugation or any filtering process, only with the application of an external magnetic field. [29][30][31] This technique provides adsorption process with high removal efficiency, easy separation, higher surface area with magnetic nanoparticles for higher adsorption capacity, and suitability for different surface modification. [29,32] In literature, only few adsorptive removal studies have been shown recently for fipronil from aqueous solution in which modified zeolites were used as adsorbents mostly.…”

“…In adsorption based separation processes, different types of adsorbents are used and the selection of the adsorbent depends on the porosity, pore structure, nature of its adsorbing surfaces, surface functional groups and most importantly applications. Magnetic solid phase extraction enables the removal of adsorbents from the solution by means of magnetic nanoparticles, without the need for centrifugation or any filtering process, only with the application of an external magnetic field [29–31] . This technique provides adsorption process with high removal efficiency, easy separation, higher surface area with magnetic nanoparticles for higher adsorption capacity, and suitability for different surface modification [29,32] …”