Magnetic-Responsive Supramolecular Vesicles From Self-Organization of Amphiphilic Pillar[5]arene and Application in Controlled Release

Abstract

A new amphiphilic pillar[5]arene (AP5-glycol) with five oligomeric glycol groups and five alkyl chains was prepared. AP5-glycol spontaneously formed bilayer vesicles in water, and these vesicles were still stable after several weeks. Additionally, when they were exposed to external physical stimuli, these vesicles also showed reversible thermal and dynamic properties. Interestingly, oleic-acid-stabilized magnetic iron oxide nanoparticles could be incorporated into the bilayer of the AP5-glycol vesicles to form hybrid magnetic-responsive supramolecular vesicles.

Preparation of ureido group bearing polymers and their upper critical solution temperature in water

“…INTRODUCTION Stimuli-responsive polymer materials have been studied in the various fields including biomedical areas such as biosensor and drug delivery system because of changes of physical properties responded to the external environmental change or external stimuli. 1 There are many reports for stimuli-responsive polymers in response to various external stimuli such as physical stimuli including light, 2 temperature, 3 magnetic field, 4 and ultrasound, 5 and chemical stimuli including pH 6 and ionic strength. 7 In general, mainly two kinds of thermoresponsive behaviors for the polymer solutions are known, that is, lower critical solution temperature (LCST) and upper critical solution temperature (UCST) behaviors.…”

Supramolecular Vesicles for Stimulus‐Responsive Drug Delivery

“…Under a magnetic field, the magnetic heating property of the iron oxide nanoparticles resulted in the deconstruction of the thermosensitive polymer vesicles to release the model drug rapidly. Diao and co‐workers utilized vesicles based on pillararene derivatives as the template to prepare vesicle/iron oxide hybrids . The nanoparticle‐appended vesicles could be deformed significantly upon an external magnetic field, realizing the cargo (calcein) release.…”

Pillarene‐Involved Metallic Supramolecular Nanostructures

“…Another example of hybrid magnetic-responsive supramolecular vesicles constructed from an amphiphilic pillar [5]arene with five oligomeric glycol groups and five alkyl chains has been reported by Diao and coworkers recently. [67] www.cjc.wiley-vch. Diao and coworkers reported a pillar [5]arene-based ternary nanocomposites which show promising sensor properties.…”