Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease

Gimpel, Charlotte; Jung, Bernd; Jung, Sora; Brado, Johannes; Schwendinger, Daniel; Burkhardt, Barbara; Pöhl, Martin; Odening, Katja E.; Geiger, Julia; Arnold, Raoul

doi:10.1007/s00247-016-3741-5

Cited by 7 publications

(6 citation statements)

References 49 publications

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“…Early diastolic peak velocity is a marker of both active relaxation and ventricular compliance [ 31 ]. Our demonstration of lower E’, measured using TPM, is in keeping with a previous smaller study in pediatric CKD [ 32 ]. In our study, E’ did not correlate with MVR or LVMht 2.7 .…”

Section: Discussionsupporting

confidence: 91%

A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

Cheang

Barber

Khushnood

et al. 2018

Journal of Cardiovascular Magnetic Resonance

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BackgroundChildren with chronic kidney disease (CKD) have increased cardiovascular mortality. Identifying high-risk children who may benefit from further therapeutic intervention is difficult as cardiovascular abnormalities are subtle. Although transthoracic echocardiography may be used to detect sub-clinical abnormalities, it has well-known problems with reproducibility that limit its ability to accurately detect these changes. Cardiovascular magnetic resonance (CMR) is the reference standard method for assessing blood flow, cardiac structure and function. Furthermore, recent innovations enable the assessment of radial and longitudinal myocardial velocity, such that detection of sub-clinical changes is now possible. Thus, CMR may be ideal for cardiovascular assessment in pediatric CKD. This study aims to comprehensively assess cardiovascular function in pediatric CKD using CMR and determine its relationship with CKD severity.MethodsA total of 120 children (40 mild, 40 moderate, 20 severe pre-dialysis CKD subjects and 20 healthy controls) underwent CMR with non-invasive blood pressure (BP) measurements. Cardiovascular parameters measured included systemic vascular resistance (SVR), total arterial compliance (TAC), left ventricular (LV) structure, ejection fraction (EF), cardiac timings, radial and longitudinal systolic and diastolic myocardial velocities. Between group comparisons and regression modelling were used to identify abnormalities in CKD and determine the effects of renal severity on myocardial function.ResultsThe elevation in mean BP in CKD was accompanied by significantly increased afterload (SVR), without evidence of arterial stiffness (TAC) or increased fluid overload. Left ventricular volumes and global function were not abnormal in CKD. However, there was evidence of LV remodelling, prolongation of isovolumic relaxation time and reduced systolic and diastolic myocardial velocities.ConclusionAbnormal cardiovascular function is evident in pre-dialysis pediatric CKD. Novel CMR biomarkers may be useful for the detection of subtle abnormalities in this population. Further studies are needed to determine to prognostic value of these biomarkers.Electronic supplementary materialThe online version of this article (10.1186/s12968-018-0444-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

Cheang

Barber

Khushnood

et al. 2018

Journal of Cardiovascular Magnetic Resonance

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“…In addition, the present study is the first to investigate both LV and RV myocardial motion with TPM in children. Compared with previously studied healthy children of younger age (38,39), LV peak velocities in this study were reduced, which agrees with the reported age dependency. Similar to our findings, prior studies demonstrated significantly decreased LV peak velocities in older subjects (28,32).…”

Section: Discussionsupporting

confidence: 90%

“…All healthy controls used in this study had normal global LV and RV function with decreased indexed volumes for adults in agreement with literature (51). Of note, this study included children, which have been rarely studied with TPM (38,39). In addition, the present study is the first to investigate both LV and RV myocardial motion with TPM in children.…”

Section: Discussionsupporting

confidence: 67%

“…In this context, 2D cine phase contrast MRI with three-directional velocity encoding, termed tissue phase mapping (TPM), is a well-established technique to quantify LV regional myocardial velocities (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41) but has rarely been applied to the RV. In 2000, Kayser et al (6) analyzed RV wall motion with TPM for the first time, and more recently biventricular function in healthy adults (42) and adult patients with pulmonary hypertension (43) have been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

Ruh

Sarnari

Berhane

et al. 2019

Int J Cardiovasc Imaging

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Purpose-The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Methods-36 healthy controls (age=1-75 years) and 12 TOF patients (age=5-23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test-retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16+10 LV+RV segment model, and assessment of inter-ventricular dyssynchrony.

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“…Trabalhos realizados em crianças e adolescentes com DRC identificaram a hipertrofia ventricular esquerda, a hipertensão arterial sistêmica e a disfunção diastólica como fatores de risco isolados para aumento da morbimortalidade cardiovascular 9,10 . Dentre esses, a disfunção diastólica parece ser a alteração mais precoce, como demonstrado em estudos que utilizaram ecocardiograma e ressonância nuclear magnética 11,12 .…”

Section: Introductionunclassified

Estudo ecocardiográfico da deformação atrial esquerda pela técnica de Speckle-tracking bidimensional em pacientes pediátricos com doença renal crônica

Penachio¹

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Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease

Cited by 7 publications

References 49 publications

A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

Estudo ecocardiográfico da deformação atrial esquerda pela técnica de Speckle-tracking bidimensional em pacientes pediátricos com doença renal crônica

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