Magnetic Resonance T
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            Relaxation Time of Venous Thrombus Is Determined by Iron Processing and Predicts Susceptibility to Lysis

Saha, Prakash; Andía, Marcelo E.; Modarai, Bijan; Blume, Ulrike; Humphries, Julia; Patel, Alpesh; Phinikaridou, Alkystis; Evans, Colin E.; Mattock, Katherine; Grover, Steven P.; Ahmad, Abdul Hamid; Lyons, Oliver; Attia, Rizwan; Renné, Thomas; Premaratne, Sobath; Wiethoff, Andrea J.; Botnar, René M.; Schaeffter, Tobias; Waltham, Matthew; Smith, Alberto

doi:10.1161/circulationaha.113.001371

Cited by 80 publications

(106 citation statements)

References 31 publications

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“…Consequently, therapeutic approaches that limit thrombus rbc content may also indirectly reduce thrombus mass and stability. A recent study of experimental thrombosis showed thrombolysis is most effective in aged thrombi containing fewer intact rbc (57). These data suggest thrombus rbc content is a central determinant of thrombolytic success.…”

Section: Discussionmentioning

confidence: 96%

Factor XIII activity mediates red blood cell retention in venous thrombi

Aleman¹,

Byrnes²,

Wang³

et al. 2014

J. Clin. Invest.

174

209

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Section: Discussionmentioning

confidence: 96%

Factor XIII activity mediates red blood cell retention in venous thrombi

Aleman¹,

Byrnes²,

Wang³

et al. 2014

J. Clin. Invest.

174

209

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“…US has limited usefulness in detection of recurrent DVT and the most promising alternative is MRDTI based on assessment of shortening T1 signal. It is highly accurate for first DVT (64,72).…”

Section: Magnetic Resonance Direct Thrombus Imaging (Mrdti)mentioning

confidence: 99%

Advanced imaging in acute and chronic deep vein thrombosis

Karande

Hedgire

Sánchez

et al. 2016

Cardiovasc. Diagn. Ther.

103

107

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“…MRDTI has been shown to be a highly accurate diagnostic test for first DVT. 9,10 The method is based on assessment of a shortening T1 signal. This signal is induced by the paramagnetic methemoglobin, which is being formed in a fresh thrombus.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance direct thrombus imaging differentiates acute recurrent ipsilateral deep vein thrombosis from residual thrombosis

Tan

Mol

Rooden

et al. 2014

Blood

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Key Points• Diagnostic management of ipsilateral recurrent DVT of the leg is complicated because residual DVT is common and mimics acute DVT on CUS.• MRDTI is able to reproducibly distinguish acute ipsilateral recurrent DVT from 6-monthold chronic residual thrombi in the leg veins.Accurate diagnostic assessment of suspected ipsilateral recurrent deep vein thrombosis (DVT) is a major clinical challenge because differentiating between acute recurrent thrombosis and residual thrombosis is difficult with compression ultrasonography (CUS). We evaluated noninvasive magnetic resonance direct thrombus imaging (MRDTI) in a prospective study of 39 patients with symptomatic recurrent ipsilateral DVT (incompressibility of a different proximal venous segment than at the prior DVT) and 42 asymptomatic patients with at least 6-month-old chronic residual thrombi and normal D-dimer levels. All patients were subjected to MRDTI. MRDTI images were judged by 2 independent radiologists blinded for the presence of acute DVT and a third in case of disagreement. The sensitivity, specificity, and interobserver reliability of MRDTI were determined. MRDTI demonstrated acute recurrent ipsilateral DVT in 37 of 39 patients and was normal in all 42 patients without symptomatic recurrent disease for a sensitivity of 95% (95% CI, 83% to 99%) and a specificity of 100% (95% CI, 92% to 100%). Interobserver agreement was excellent (k 5 0.98). MRDTI images were adequate for interpretation in 95% of the cases. MRDTI is a sensitive and reproducible method for distinguishing acute ipsilateral recurrent DVT from 6-month-old chronic residual thrombi in the leg veins. (Blood. 2014;124(4):623-627)

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Magnetic Resonance T ₁ Relaxation Time of Venous Thrombus Is Determined by Iron Processing and Predicts Susceptibility to Lysis

Abstract: The source of the T1 signal in the thrombus results from the oxidation of iron (released from the lysis of trapped erythrocytes in the thrombus) to its paramagnetic Fe3+ form. Quantification of T1 relaxation time appears to be a good predictor of the success of thrombolysis.

Cited by 80 publications

References 31 publications

Factor XIII activity mediates red blood cell retention in venous thrombi

Factor XIII activity mediates red blood cell retention in venous thrombi

Advanced imaging in acute and chronic deep vein thrombosis

Magnetic resonance direct thrombus imaging differentiates acute recurrent ipsilateral deep vein thrombosis from residual thrombosis

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Magnetic Resonance T 1 Relaxation Time of Venous Thrombus Is Determined by Iron Processing and Predicts Susceptibility to Lysis

Abstract: The source of the T1 signal in the thrombus results from the oxidation of iron (released from the lysis of trapped erythrocytes in the thrombus) to its paramagnetic Fe3+ form. Quantification of T1 relaxation time appears to be a good predictor of the success of thrombolysis.

Cited by 80 publications

References 31 publications

Factor XIII activity mediates red blood cell retention in venous thrombi

Factor XIII activity mediates red blood cell retention in venous thrombi

Advanced imaging in acute and chronic deep vein thrombosis

Magnetic resonance direct thrombus imaging differentiates acute recurrent ipsilateral deep vein thrombosis from residual thrombosis

Contact Info

Product

Resources

About

Magnetic Resonance T ₁ Relaxation Time of Venous Thrombus Is Determined by Iron Processing and Predicts Susceptibility to Lysis