Magnetic resonance studies on the interaction of antidepressants with lipid model membranes

Bermejo, José Carlos; Barbadillo, A.; Tato, Fernando; Chapman, Dail

doi:10.1016/0014-5793(75)80640-5

Cited by 10 publications

(1 citation statement)

References 8 publications

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“…The disappearance of the pre transition, which is related to the interaction between the choline moiety and the bound water,I4 could indicate a drug localization in the polar region of the phospholipids; the lowering of the chain melting transition without enthalpy decrease suggests that the drug interacts with the head group and only partially penetrates between the chains. 15 The X-ray diffraction patterns showed in Figure 4 indicate that the structure observed for phenobarbital molar ratio lower than 0.05, at room temperature, is a L,, phase; considering also that the measured lamellar thickness is about 6.8 nm, we estimate that this structure corresponds roughly to a unperturbed lamellar L,. phase of pure DSPC.'…”

Section: Discussionmentioning

confidence: 95%

Study of Perturbations Induced by a Barbituric, the Phenobarbital, on DSPC Multilamellar Liposomes

Albertini

Dubini

Gobbi

et al. 1992

Molecular Crystals and Liquid Crystals Science and Technology.

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Multilamellar liposomes of distearoyl phosphatidyl choline in excess water condition, doped by the barbituric drug Phenobarbital, in molar ratios between 0 and 0.5, were studied by using differential scanning calorimetry, X-ray diffraction and electron microscopy. The results suggest that the drug interacts with the lipid headgroup region: in particular, at the higher concentrations investigated, an interdigitated "gel phase," with rigid chains, stiff and perpendicular to the lamellar planes, seems to be induced.

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Section: Discussionmentioning

confidence: 95%

Study of Perturbations Induced by a Barbituric, the Phenobarbital, on DSPC Multilamellar Liposomes

Albertini

Dubini

Gobbi

et al. 1992

Molecular Crystals and Liquid Crystals Science and Technology.

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Binding of imipramine and cocaine to a model lipid membrane

1984

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[3H]Imipramine and [3H]cocaine were concentrated at membranes of liposomes prepared from phosphatidylcholine, cholesterol, and dicetylphosphate. This "binding" has an apparent dissociation constant in the micromolar range and a density close to 2 pmol/micrograms of phosphatidylcholine. The potencies of various drugs in inhibiting the binding to liposomes correlated only weakly with those in inhibiting the high-affinity binding of [3H]imipramine and [3H]cocaine to brain membranes. However, there was a highly significant correlation between the potencies of drugs in inhibiting binding to liposomes and their lipophilic character, indicating the involvement of hydrophobic bonding. Although the amounts of phosphatidylcholine and cholesterol in brain preparations in assays for high-affinity binding to brain membranes were in the same range as those used in our assays with liposomes, the inhibition of the high-affinity binding to brain membranes was only weakly dependent upon the lipophilicity of the inhibiting drug. These results indicate that lipophilicity is but one of the factors in the complex binding interactions between lipophilic substances and integral brain membranes. In addition, the results are in agreement with the suggestion that phosphatidylcholine and cholesterol are not the primary sites of high-affinity binding [3H]imipramine and [3H]cocaine to brain membranes, although it cannot be ruled out that these lipids have different properties in natural biological membranes and in artificial liposome membranes.

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Calorimetric, 13C NMR, and 31P NMR studies on the interaction of some phenothiazine derivatives with dipalmitoyl phosphatidylcholine model membranes

Frenzel

Arnold

Nuhn

1978

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Magnetic resonance studies on the interaction of antidepressants with lipid model membranes

Cited by 10 publications

References 8 publications

Study of Perturbations Induced by a Barbituric, the Phenobarbital, on DSPC Multilamellar Liposomes

Study of Perturbations Induced by a Barbituric, the Phenobarbital, on DSPC Multilamellar Liposomes

Binding of imipramine and cocaine to a model lipid membrane

Calorimetric, 13C NMR, and 31P NMR studies on the interaction of some phenothiazine derivatives with dipalmitoyl phosphatidylcholine model membranes

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