Magnetic Resonance Spectroscopic and Histopathological Findings in the Supratentorial Brain Space Occupying Lesions

Abbas, Asad; Javeed, Farrukh; Rehman, Lal; Afzal, Ali R.; Rizvi, Raza

doi:10.36552/pjns.v24i3.423

Cited by 1 publication

(2 citation statements)

References 15 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, several other cut-off values are assigned for these markers to diagnose the accuracy of MRS 11,12 . Our patients were predominantly male (67.9%) of the patients which was consistent with the other studies 10,11 . In our study, the sensitivity was reported to be 82.4% and the value of specificity was 70.4%.…”

Section: Discussionsupporting

confidence: 92%

“…Sample size: A Raosoft sample size calculator was utilized to estimate the sample size for this study. The margin of error of 5%, the 95% confidence interval, and the expected incidence of the supratentorial lesions to be 156 10 were used to calculate the sample size of 112 patients. Inclusion Criteria: The inclusion criteria of our study include patients withconventional MR showing space-occupying lesions (SOL)and malignant diffusion restriction along with enhancement, and patients of age 18 or above.…”

Section: Methods Study Designmentioning

confidence: 99%

See 1 more Smart Citation

Role of Magnetic Resonance Spectroscopy in Supratentorial Brain Lesions

Qadir¹,

Rehman²,

Bokhari³

et al. 2023

PJMHS

View full text Add to dashboard Cite

Aim: To identify the specificity and the sensitivity of MRS in diagnosing supratentorial brain lesions and will help the surgeons to rely on the respective diagnostic modality Method: A cross-sectional study was conducted in the Neurosurgery Department, at Jinnah Postgraduate Medical Center. The patients with conventional MR imaging showing space-occupying lesions which show a malignant diffusion restriction and enhancement were included. The histopathological diagnosis and the metabolites of the brain were detected by MR Spectroscopy were recorded. To find the association of the ratios of the brain metabolites, the chi-square test was used where a p-value of <0.05 was considered significant. The sensitivity and specificity of the MRS were evaluated then. Result: Overall, 112 patients were included in our study. 76(67.9%) patients were male. Headache (34.8%) was found to be the most common symptom. 39(34.8%) patients were diagnosed with Oligodendroglioma on histopathology. The Cho/Cr ratio >2 was found in 70(82.4%) patients diagnosed with neoplastic lesions. In 62(72.9%) patients diagnosed to have a neoplastic lesion on histopathology reported increased lipid peak and 67(78.8%) with the neoplastic lesion showed to have increased Cho/NAA ratio on MRS. The Cho/Cr ratio was found to be significantly associated with the neoplastic lesions with a significant p-value of <0.001. The MRS was determined to be 82.4% sensitive and 70.4% specific in the diagnosis of supratentorial brain lesions. This study will be quite beneficial as it will help surgeons rely on the more accurate method of diagnosing brain lesions and provide an outlook of a non-invasive method to diagnose the lesions. Conclusion: The study concludes that MRS has high diagnostic accuracy in diagnosing neoplastic and inflammatory lesions and is Keywords: Spectroscopy, brain lesions, medical resonance imaging

show abstract