Magnetic Resonance Imaging

Truhan, Andrew P.

doi:10.1001/archderm.1993.01680230103016

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Cited by 22 publications

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“…Finding no correlation with neurological dysfunction, most early reports speculated that these bright objects of unknown significance were hamartomas or low-grade neoplasms [18,19,20]. It was later confirmed that UBOs could occur anywhere within the central nervous system, however, were most prevalent within the basal ganglia (19%), cerebellar hemispheres (49%), and brainstem (22%) [13,14,15].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Pontine Lesions in Children with Neurofibromatosis Type 1: Making a Case for Unidentified Bright Objects

et al. 2013

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Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.

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