Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine

Mahmoudi, Morteza; Hosseinkhani, X Hossein; Hosseinkhani, Mohsen; Boutry, Sébastien; Simchi, A.; Journeay, W. Shane; Subramani, Karthikeyan; Laurent, Sophie

doi:10.1021/cr1001832

Cited by 390 publications

(292 citation statements)

References 413 publications

(514 reference statements)

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“…53 Nanomaterials could influence the fate of differentiation of these cells or enable the detection of migration and homing of cells. To track the migration and homing of transplanted cells 13 , techniques like bioluminescence 54 , ! radioactive substrates 55 , near-infrared fluorescence 56 , and labeling with magnetic resonance imaging (MRI) contrast agents 13,57 are applied in small animal studies.…”

Section: The Role Of Surface Charge and Protein Corona On Np Uptakementioning

confidence: 99%

“…To track the migration and homing of transplanted cells 13 , techniques like bioluminescence 54 , ! radioactive substrates 55 , near-infrared fluorescence 56 , and labeling with magnetic resonance imaging (MRI) contrast agents 13,57 are applied in small animal studies. Of these, only labeling with radioactive agents and MRI contrast agents are suitable for studies in humans.…”

Section: The Role Of Surface Charge and Protein Corona On Np Uptakementioning

confidence: 99%

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Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Rauch¹,

Kölch²,

et al. 2013

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Introduction 3391 2. Medical Applications of Nanomaterials 3391 2.1. Use of Nanomaterials in Diagnostic Applications 3392 3. Interaction of Nanomaterials with Living Cells 3392 3.1. Role of Physicochemical NP Properties in the Interaction between NPs and Biological Systems 3393 3.2. NP Uptake into the Cells 3393 3.2.1. Role of Size and Shape in NP Uptake 3393 3.2.2. Role of Surface Charge and Protein Corona on NP Uptake 3395 3.3. Activation of Signal Processing Pathways by NPs 3397 3.3.1. Interaction of NPs with Cell Membrane Receptors 3397 3.3.2. Role of Oxidative Stress and ROS in NP-Induced Signaling 3398 3.3.3. NPs Induce Cell Death Pathways 3400 3.3.4. Activation of Mechanotransduction Receptors by Magnetic NPs 3400 4. Magnetic NPs and Cell Signaling 3400 4.1. Controlled Activation of Cell Surface Receptors by Magnetic NPs 3400 4.1.1. Activation of Signal Transduction Receptors by Magnetic NPs 3400 4.1.2. Activation of Mechanotransduction Receptors and Mechanosensitive Signaling Pathways by Magnetic NPs 3400 4.2. Pathway Activation by Magnetic-NP-Induced Hyperthermia 3401 4.2.1. Molecular Targets of Hyperthermia: Heat Shock Proteins and p53 3401 5. Conclusions 3402 Author Information 3402 Corresponding Author 3402 Present Address 3402 Notes 3402 Biographies 3402 Acknowledgments 3403 References 3403

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Section: The Role Of Surface Charge and Protein Corona On Np Uptakementioning

confidence: 99%

Section: The Role Of Surface Charge and Protein Corona On Np Uptakementioning

confidence: 99%

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Rauch¹,

Kölch²,

et al. 2013

Self Cite

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“…magnetic properties and antibody attachment [23]. Superparamagnetism acts as an activation mechanism because once the external magnetic field is eliminated, the magnetization disappears, and hence the possible embolization of the capillary vessels can be avoided [24].…”

Section: Discussionmentioning

confidence: 99%

Biomimetically Synthesized Aqueous Ferrofluids Having Antibacterial and Anticancer Properties

Sheikh¹,

Vohra²,

Verma³

et al. 2015

MSA

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Synthesis of functional iron oxide nanoparticles, well dispersed in aqueous fluids still remains a challenge as its stability requires a delicate balance between electrostatic and magnetic interactions. Templated synthesis using biomolecules is useful because the biomolecules have their unique arrangement in aqueous systems that enhance stability, commonly called "biomimetic synthesis". We have developed a one-pot in-situ, low energy process for the synthesis of highly monodispersed, Collagen Functionalized Ferrofluids (CFF) as a templating agent in an aqueous medium. The nanoparticles so obtained were characterized by X-ray diffraction (

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“…38 Although only a few studies have been done, research has indeed showed that there is effective non-invasive tracking of labeled human embryonic stem cells using MRI imaging. The first study that attempted clinical MRI tracking of therapeutic cells in humans was first reported in 2005.…”

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confidence: 99%

Stem cell tracking using iron oxide nanoparticles

Bull¹,

Madani²,

Sheth³

et al. 2014

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) are an exciting advancement in the field of nanotechnology. They expand the possibilities of noninvasive analysis and have many useful properties, making them potential candidates for numerous novel applications. Notably, they have been shown that they can be tracked by magnetic resonance imaging (MRI) and are capable of conjugation with various cell types, including stem cells. In-depth research has been undertaken to establish these benefits, so that a deeper level of understanding of stem cell migratory pathways and differentiation, tumor migration, and improved drug delivery can be achieved. Stem cells have the ability to treat and cure many debilitating diseases with limited side effects, but a main problem that arises is in the noninvasive tracking and analysis of these stem cells. Recently, researchers have acknowledged the use of SPIONs for this purpose and have set out to establish suitable protocols for coating and attachment, so as to bring MRI tracking of SPION-labeled stem cells into common practice. This review paper explains the manner in which SPIONs are produced, conjugated, and tracked using MRI, as well as a discussion on their limitations. A concise summary of recently researched magnetic particle coatings is provided, and the effects of SPIONs on stem cells are evaluated, while animal and human studies investigating the role of SPIONs in stem cell tracking will be explored.

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Magnetic Resonance Imaging Tracking of Stem Cells in Vivo Using Iron Oxide Nanoparticles as a Tool for the Advancement of Clinical Regenerative Medicine

Cited by 390 publications

References 413 publications

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

Biomimetically Synthesized Aqueous Ferrofluids Having Antibacterial and Anticancer Properties

Stem cell tracking using iron oxide nanoparticles

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