Magnetic resonance imaging studies of the brains of schizophrenic patients

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

“…These Observations are in line with a long series of reports claiming morphological changes of the CC in schizophrenic persons Nasrallah et al, 1983;Rosenthai and Bigelow, 1972). However, morphometric data obtained post mortem and by means of MRI are contradictory, the former reporting a thickening of the CC, the latter a reduction (Rossi et al, 1988Stratta et al, 1989) and some studies no differences (Kelsoe et al, 1988;Smith et al, 1987), except for a longerCC in schizophrenics. The most recent magnetic resonance imaging (MRI) data have failed to reveal substantial differences in the cross-sectional area between Schizophrenie and control persons.…”

Meta-analysis of corpus callosum size in schizophrenia.

“…Using computerised and manual literature searches (Medline, PsychLit, and Index Medicus), 17 23 28-32 From these, information was extracted pertaining to three groups of factors: "dependent" variables, "study quality" variables, and "predictors of differences" between schizophrenic patients and controls (table 1). Dependent variables included midsagittal measures of corpus callosum area (cm2), brain area (cm2), and corpus callosum length (cm).…”

Abstracts-part V (Continue in Part VI)

“…Recent studies have reported structural brain abnormalities in schizophrenic patients using magnetic resonance imaging (MRI) and CT. In an MRI study of schizophrenic and controls we have previously reported (Smith et al, 1987) increased T1 weighted image intensities in the brains of schizophrenics, but normal ventricular size. In an independent MRI investigation of schizophrenic patients, Andreasen and Associates (1986) have reported decreased frontal lobe size and decreased cranial size in a series of schizophrenic patients, using measurements taken primarily from saggital cuts These findings have not been replicated.…”

“…They received an M R I head scan with standardized procedures using T1 weighted images with an .3 Tesla technicare superconducting magnet. (Details of scanning procedures have been previously reported; Smith et al, 1987). 97 patients with schizophrenia or schizoaffective disorder and 27 controls had previously been scanned, with standardized 5mm cuts, with a CT GE8800 scanner, with procedures previously described in detail (Largen et al, 1984).…”

“…97 patients with schizophrenia or schizoaffective disorder and 27 controls had previously been scanned, with standardized 5mm cuts, with a CT GE8800 scanner, with procedures previously described in detail (Largen et al, 1984). Quantitative area measurements of the following brains structures were made from MRI films using planometric techniques from enlarged drawings, following procedures used in our previous work (Smith et al, 1987): Saggital cuts-frontal lobe, pre-frontal lobe, brain size cranial size; coronal cuts-right and left temporal lobe size, brain size, cranial size; transverse cut -brain size, cranial size. From transverse cuts of the CT scans, at the level of the frontal horns and trigone, we made measurements of brain size and cranial size in a series of 97 patients with schizophrenia or schizoaffective psychosis and 27 headache controls.…”