Magnetic resonance imaging strategies for heart studies.

Crooks, Lawrence E.; Barker, Bruce; Chang, Hsun-Hsien; Feinberg, David; Hoenninger, J; Watts, J C; Arakawa, M; Kaufman, Leo; Sheldon, P E; Botvinick, Elias H.

doi:10.1148/radiology.153.2.6484178

Cited by 71 publications

(9 citation statements)

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“…Thus the images spanned from end-diastole through end-systole and into diastole, most of the cardiac cycle. A cycled multislice approach to image acquisition was adopted to yield each of n image slices at many time points of the cardiac cycle (Crooks et al 1984;Pettigrew, 1989). Typically 12 scans were acquired, one for each image slice, for each imaged cardiac cycle.…”

Section: Temporal Synchronization Of Image Acquisitionmentioning

confidence: 99%

Magnetic resonance imaging analysis of left ventricular function in normal and spontaneously hypertensive rats

Wise

Huang

Gresham

et al. 1998

The Journal of Physiology

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We have used magnetic resonance imaging (MRI) to examine acute morphological changes in the left ventricle throughout the cardiac cycle in normal Wistar Kyoto rats (WKY) and also to follow the development of chronic changes in spontaneously hypertensive rats (SHR). This involved the development of MRI and quantitative analysis techniques for characterizing contractile changes during the cardiac cycle. Images of the cardiac anatomy in two age groups (8 and 12 weeks old) of young anaesthetized adult normal WKY and SHR were acquired in planes both parallel and perpendicular to the principal cardiac axis. Complete coverage of the heart by imaging planes was achieved with high time resolution (13 ms), with typically 12 time frames in the cardiac cycle, using a short echo time (5 ms) multislice gradient‐echo imaging sequence. Imaging was synchronized to the R wave of the electrocardiogram. The image slices could be reconstructed into complete geometrically and temporally coherent three‐dimensional data sets. Left ventricular (LV) volumes were thus reconstructed throughout the cardiac cycle by combining transverse cardiac image sections. This volume analysis revealed structural and functional differences between the normal WKY and SHR in both age groups of 8 and 12 weeks. Measurements from the cardiac images were additionally validated against histological measurements. The SHR showed a raised LV end‐systolic volume and a correspondingly poorer ejection fraction as well as LV hypertrophy when compared with the controls. Left ventricular function in the SHR appeared stable between the two age groups. We developed a simple geometrical model of the left ventricle based on a single longitudinal image section and successfully used this to describe some functional parameters of the left ventricle in the WKY and SHR. This geometrical model has the potential to greatly reduce the imaging time needed to study the beating heart in future serial investigations of cardiac physiology in rats. Our experimental and analytical methods together form a powerful set of quantitative techniques which combine both imaging and functional analysis and will be applicable for future studies of chronic physiological changes in animal disease models.

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Section: Temporal Synchronization Of Image Acquisitionmentioning

confidence: 99%

Magnetic resonance imaging analysis of left ventricular function in normal and spontaneously hypertensive rats

Wise

Huang

Gresham

et al. 1998

The Journal of Physiology

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“…All sections are obtained at the same point of the cardiac cycle. At an expense of total imaging time, the 3-D mode is capable of achieving very thin sections (1.8ram) with improved signal-to-noise ratios (12). We have also achieved thin (2.5 mm) and medium (5.0 mm) slices with no gaps using a multislice technique that engenders a less drastic increase in imaging time.…”

Section: Normal Cardiac Anatomymentioning

confidence: 93%

“…Five sections easily fit within a cardiac cycle. With this type of multi-section and double-echo imaging, five tomographic planes of the heart can be examined within six to ten minutes for a usual heart rate of 80 to 100 beats per minute (12). However, the time interval between trigger and data collection changes as we advance from slice to slice.…”

Section: Ecggadngmentioning

confidence: 99%

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Magnetic resonance imaging of the heart

Tscholakoff

Higgins

1985

Int J Cardiac Imag

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SummaryMagnetic resonance imaging (MRI) is a completely noninvasive technique for the evaluation of the cardiovascular system. With a multi-section technique and the spin echo pulse sequence the entire heart can be examined within six to ten minutes. All our cardiac MR studies were performed with electrocardiographic (ECG) gating, to obtain adequate resolution of the cardiac structures. With this technique, patients and animals with a variety of cardiac abnormalities were studied. The examined pathologic conditions included acute and chronic myocardial infarctions and their complications, hypertrophic and congestive cardiomyopathies, congenital heart diseases and pericardial diseases. MRI offers an enormous potential for cardiovascular diagnosis, even beyond the demonstration of pathoanatomy, because of the capability for direct tissue characterization and blood flow measurements.

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“…There are several techniques which can be used for cardiac imaging [1]. Depending upon the information sought, each has advantages.…”

Section: Cardiac Imaging Techniquesmentioning

confidence: 99%