Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls

Regnell, Simon E.; Peterson, Pernilla; Trinh, Lena; Broberg, Per; Leander, Peter; Lernmark, Åke; Månsson, Sven; Larsson, Helena Elding

doi:10.1016/j.metabol.2015.04.002

Cited by 31 publications

(30 citation statements)

References 26 publications

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“…This relationship seems to be mediated by general obesity, and it is currently not established whether such a relationship exists when the fat contents of the organs are low. We have previously reported that children with Type 1 diabetes had a significantly lower hepatic fat fraction (1.3%) than controls (1.8%), consistent with studies on adults with Type 1 diabetes [11,12]. Because insulin promotes fat accumulation, the lower hepatic fat fraction is hypothesized to be caused by less insulin in Type 1 diabetes reaching the liver through the portal vein.…”

Section: Introductionsupporting

confidence: 86%

Pancreas volume and fat fraction in children with Type 1 diabetes

et al. 2016

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Our findings do not indicate that pancreatic atrophy in Type 1 diabetes is associated with an increased pancreatic fat fraction, unlike some other diseases featuring reduced pancreatic volume. We speculate that our results may support the hypotheses that much of pancreatic atrophy in Type 1 diabetes occurs before the clinical onset of the disease and that exogenous insulin administration decelerates pancreatic atrophy after diabetes onset.

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Section: Introductionsupporting

confidence: 86%

Pancreas volume and fat fraction in children with Type 1 diabetes

et al. 2016

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“…Lipid synthesis was found to be reduced in T1D, which is characterized by diminished production of insulin . In addition, insulin therapy was established to stimulate the lipogenesis and weight gain in patients with T1D . In this study, we found a decrease in FAS expression in both male and female OVE26 mice at the same age, which is in agreement with the findings of the above‐mentioned human studies.…”

Section: Discussionmentioning

confidence: 99%

Hepatic functional and pathological changes of type 1 diabetic mice in growing and maturation time

Jiang

Tang

Wang

et al. 2019

J Cellular Molecular Medi

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To detect the changes in the liver function in both male and female OVE26 mice from young to adults for better understanding of type 1 diabetes‐induced hepatic changes, OVE26 mice and wild‐type FVB mice were raised in the same environment without any intervention, and then killed at 4, 12, 24 and 36 weeks for examining liver's general properties, including pathogenic and molecular changes. The influence of diabetes on the bodyweight of male and female mice was different. Both male and female OVE26 mice did not obtain serious liver injury or non‐alcoholic fatty liver disease, manifested by mild elevation of plasma alanine transaminase, and less liver lipid content along with significantly suppressed lipid synthesis. Uncontrolled diabetes also did not cause hepatic glycogen accumulation in OVE26 mice after 4 weeks. Oxidative stress test showed no change in lipid peroxidation, but increased protein oxidation. Changed endoplasmic reticulum stress and apoptosis along with increased antioxidant capacity was observed in OVE26 mice. In conclusion, uncontrolled type 1 diabetes did not cause hepatic lipid deposition most likely because of reduced lipids synthesis in response to insulin deficiency. Enhanced antioxidant capacity might not only prevent the occurrence of severe acute liver injury but also the self‐renewal, leading to liver dysfunction.

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“…While T2D is often associated with non‐alcoholic fatty liver disease, it might be predicted that T1D would demonstrate the opposite phenotype. This has now been confirmed in several studies using magnetic resonance imaging and spectroscopy: reduced liver fat was demonstrated in lean patients with T1D compared with matched controls 28 and also in children with T1D . Of particular interest is a study in overweight (BMI 28.9 kg/m 2 ) patients with T1D compared with a matched control group.…”

Section: Contrasting Features Of Types 1 and 2 Diabetesmentioning

confidence: 96%

“…insulin resistance, ectopic fat deposition, shift to fat oxidation Bergman BC, et al Perseghin G, et alThe liver phenotype in T1D is ‘opposite’ to that in T2D in terms of liver fat and lipoprotein output. Imposing T2D features on this may result in adverse CV consequences via ectopic fat deposition and a more atherogenic lipid profile Perseghin G, et al Regnell SE, et al Llaurado G, et al Prince CT, et alPrevalence of double diabetes is 25% of T1D, but may vary depending on how it is defined. It is likely that the incidence will continue to rise due to the combination of an obesogenic environment and tightening of glycaemic targets Merger SR, et al Conway B, et al Ferriss JB, et al…”

Section: Double Diabetes: Clinical Implicationsmentioning

confidence: 99%

Double diabetes: the cardiovascular implications of combining type 1 with type 2 diabetes

Cleland

2017

Practical Diabetes

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Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls

Cited by 31 publications

References 26 publications

Pancreas volume and fat fraction in children with Type 1 diabetes

Pancreas volume and fat fraction in children with Type 1 diabetes

Hepatic functional and pathological changes of type 1 diabetic mice in growing and maturation time

Double diabetes: the cardiovascular implications of combining type 1 with type 2 diabetes

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