Magnetic resonance imaging reflects cartilage proteoglycan degradation in the rabbit knee

Paul, Pradip Kumar; O’Byrne, E. M.; Blancuzzi, V.; Wilson, Douglas E.; Gunson, Diane E.; Douglas, Frank L.; Wang, Jin Zhao; Mezrich, Reuben

doi:10.1007/bf00243718

Cited by 60 publications

(34 citation statements)

References 21 publications

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“…2E versus 2A) was only slightly diminished compared with the untreated knee (87 2 7%; n = 6). This result is in accordance with findings that the removal of PG from the cartilage does not significantly alter its MRI properties [TI, T,, and proton density) (7). MR images of the papain-treated knees revealed no surface irregularities or focal defects of the cartilage.…”

Section: Resultssupporting

confidence: 94%

MRI contrast enhanced study of cartilage proteoglycan degradation in the rabbit knee

Bačić

Liu

Goda

et al. 1997

Magnetic Resonance in Med

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Early degeneration of cartilage is accompanied by a loss of proteoglycans and consequent changes in the content of water. Conventional magnetic resonance imaging (MRI) cannot reliably detect this change, since the relaxation properties of the cartilage are dominated by its collagen content. The applicability of a positively charged nitroxide as an MRI contrast agent in detection of the content of the negatively charged proteoglycans within the cartilage was investigated. The results from both MRI and electron paramagnetic resonance (EPR) spectroscopy indicate that the accumulation of the contrast agent reflects the amount of proteoglycans within the cartilage, presumably due to the electrostatic interactions between the negatively charged proteoglycans and the positively charged nitroxide. Such a contrast agent could be useful in the detection and study of early stages of the degeneration of joints.

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Section: Resultssupporting

confidence: 94%

MRI contrast enhanced study of cartilage proteoglycan degradation in the rabbit knee

Bačić

Liu

Goda

et al. 1997

Magnetic Resonance in Med

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“…Although some studies show that MRI assessment of the vascularity of the proximal scaphoid does not predict whether a fracture will unite after conservative treatment [31], MRI is still considered the most reliable test for the pre-operative diagnosis of avascular necrosis and is the test used most frequently in this setting [19,32]. According to Donati et al [33], MRI without contrast better diagnosed avascular necrosis of the proximal segment of the scaphoid compared to MRI with gadolinium contrast, and tests without contrast were simpler and safer [33].…”

Section: Discussionmentioning

confidence: 99%

Scaphoid fracture nonunion: correlation of radiographic imaging, proximal fragment histologic viability evaluation, and estimation of viability at surgery

Bervian

Ribak

Livani

2014

International Orthopaedics (SICOT)

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Purpose The purpose of this study was to correlate the preoperative imaging, vascularity of the proximal pole, and histology of the proximal pole bone of established scaphoid fracture non-union. Methods This was a prospective non-controlled experimental study. Patients were evaluated pre-operatively for necrosis of the proximal scaphoid fragment by radiography, computed tomography (CT) and magnetic resonance imaging (MRI). Vascular status of the proximal scaphoid was determined intra-operatively, demonstrating the presence or absence of puncate bone bleeding. Samples were harvested from the proximal scaphoid fragment and sent for pathological examination. We determined the association between the imaging and intra-operative examination and histological findings. Results We evaluated 19 male patients diagnosed with scaphoid nonunion. CT evaluation showed no correlation to scaphoid proximal fragment necrosis. MRI showed marked low signal intensity on T1-weighted images that confirmed the histological diagnosis of necrosis in the proximal scaphoid fragment in all patients. Intra-operative assessment showed that 90 % of bones had absence of intra-operative puncate bone bleeding, which was confirmed necrosis by microscopic examination. Conclusions In scaphoid nonunion MRI images with marked low signal intensity on T1-weighted images and the absence of intra-operative puncate bone bleeding are strong indicatives of osteonecrosis of the proximal fragment.

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“…Paul et al [36] in their pioneer in vivo study on rabbit knees obtained T1-, PDand T2-weighted images at 312-µm resolution after intra-articular injection of papain. They found that reduced articular cartilage thickness on the MR images of papain-treated knees corresponded to changes in cartilage proteoglycan content.…”

Section: Pathomimetic Studies and Contrast Agentsmentioning

confidence: 99%

MR microscopy of hyaline cartilage: current status

Cova

Toffanin²

2001

Eur Radiol

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Cartilage degenerative diseases, such as osteoarthritis, affect million of people. Magnetic resonance imaging is presently the most accurate imaging modality in evaluating the state of hyaline cartilage; however, clinical MRI does not accurately reveal early degenerative alterations in cartilage, due mainly to low spatial resolution. Magnetic resonance microscopy (MRM, or microMRI) appears exceptionally well suited to the in vitro or ex vivo study of this heterogeneous tissue, due to its high spatial resolution; however, despite this, further studies are necessary to evaluate the potential of MRM in the detection of early cartilage damage. Herein we briefly review the current applications of MRM in the study of hyaline cartilage. In particular, we review the MR appearance of hyaline cartilage on high-resolution images, the different MRM techniques used to image normal and enzymatically or chemically degraded cartilage and the potential use of contrast agents. The future directions and the relevance of MRM findings for a better understanding of cartilage physiology in health and disease are also discussed.

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Magnetic resonance imaging reflects cartilage proteoglycan degradation in the rabbit knee

Cited by 60 publications

References 21 publications

MRI contrast enhanced study of cartilage proteoglycan degradation in the rabbit knee

MRI contrast enhanced study of cartilage proteoglycan degradation in the rabbit knee

Scaphoid fracture nonunion: correlation of radiographic imaging, proximal fragment histologic viability evaluation, and estimation of viability at surgery

MR microscopy of hyaline cartilage: current status

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