Magnetic resonance imaging of the thalamus in male patients with schizophrenia

Deicken, Raymond F.; Eliaz, Y.; Chosiad, L.; Feiwell, Robert; Rogers, Linda

doi:10.1016/s0920-9964(01)00330-9

Cited by 36 publications

(24 citation statements)

References 38 publications

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“…r Coscia et al r r 1242 r verges with a volumetric MR imaging study reporting greater right compared with left thalamus volume in male schizophrenia patients [Deicken et al, 2002]. Similarly, our results are consistent with a recent study [Kovalev et al, 2003] investigating sex effects on brain asymmetry in a cohort of 380 healthy adults.…”

Section: Discussionsupporting

confidence: 91%

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Coscia

Narr

Robinson

et al. 2008

Human Brain Mapping

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Thalamic abnormalities have been implicated in the pathogenesis of schizophrenia, although the majority of studies used chronic samples treated extensively with antipsychotics. Moreover, the clinical and neuropsychological correlates of these abnormalities remain largely unknown. Using high-resolution MR imaging and novel methods for shape analysis, we investigated thalamic subregions in 35 (25 M/10 F) first-episode schizophrenia patients compared with 33 (23 M/10 F) healthy volunteers. The right and left thalami were traced bilaterally on coronal brain slices and volumes were compared between groups. In addition, regional abnormalities were identified by comparing distances, measured from homologous thalamic surface points to the central core of each individual's surface model, between groups in 3D space. Patients had significantly less total thalamic volume compared with healthy volunteers. Statistical mapping demonstrated most pronounced shape abnormalities in the pulvinar; however, estimated false discovery rates in these regions were sizable. Smaller thalamus volume was significantly correlated with worse overall neuropsychological functioning and specific deficits were observed in the language, motor, and executive domains. There were no significant associations between thalamus volume and positive or negative symptoms. Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates.

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Section: Discussionsupporting

confidence: 91%

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Coscia

Narr

Robinson

et al. 2008

Human Brain Mapping

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“…Though previous studies reported that the volume of thalamus could be modulated under anti-psychotic drug treatment from as early as weeks (Dazzan et al 2005) to several years (Gur et al 1998a;van Haren et al 2007), most of them focused on the effects of typical and atypical agents rather than the timing of this modulation occur. Atypical anti-psychotic treatments were reported to be particularly associated with the thalami enlargement (Dazzan et al 2005) (Scherk and Falkai 2006), while other studies have found reduced thalamic volume in chronic patients treated from typical to Olanzapine (Khorram et al 2006) or failed to detect significant thalamic volume change in medicated schizophrenic patients (Deicken et al 2002). However, Lewis and Lieberman contend that different anti-psychotic drugs appear to perform more similarly than previously thought (Leucht et al 2009(Leucht et al , 2003.…”

Section: Neuroplasticity Induced By Anti-psychotic Drugsmentioning

confidence: 98%

A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia

et al. 2009

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“…Thalamic pathology has not been a universal finding in schizophrenia. Several in vivo imaging and postmortem studies have failed to find abnormalities in thalamic volume or neuronal number in schizophrenic subjects (Portas et al, 1998;Arciniegas et al, 1999;Deicken et al, 2002;Cullen et al, 2003;Dorph-Petersen et al, 2004;Preuss et al, 2005). Moreover, recent neuroimaging analyses of the hippocampus (Csernansky et al, 2002) and thalamus (Csernansky et al, 2004) in the same cohort of schizophrenic subjects has indicated that pathology of one or the other structure may be more pronounced in different individuals (Csernansky, personal communication).…”

Section: Comparable Cell Number In Schizophrenic and Control Subjectsmentioning

confidence: 99%

“…In addition, postmortem studies of brains from schizophrenic subjects have reported a reduction in total neuronal number and volume of individual thalamic nuclei, e.g., the mediodorsal, anterior, pulvinar and ventral lateral posterior nuclei (Pakkenberg, 1990;Popken et al, 2000;Young et al, 2000;Byne et al, 2002;Danos et al, 2002;. It should be noted, however, that several studies have not found evidence of thalamic pathology in schizophrenic subjects (Portas et al, 1998;Arciniegas et al, 1999;Deicken et al, 2002;Cullen et al, 2003;Dorph-Petersen et al, 2004;Preuss et al, 2005). Moreover, all of the thalamic nuclei that have been implicated in schizophrenia are reciprocally connected with higher association cortices; therefore, it is not clear whether thalamic neuronal deficits in schizophrenia extend to sensory thalamic nuclei, such as the LGN.…”

Section: Introductionmentioning

confidence: 99%

Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects

Selemon

Begovic

2007

Psychiatry Research

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Reduction of volume and neuronal number has been found in several association nuclei of the thalamus in schizophrenic subjects. Recent evidence suggests that schizophrenic patients exhibit abnormalities in early visual processing and that many of the observed perceptual deficits are consistent with dysfunction of the magnocellular pathway, i.e. the visual relay from peripheral retinal cells to the two ventrally located magnocellular layers of the lateral geniculate nucleus (LGN). The present study was undertaken to determine whether abnormalities in cell number and volume of the LGN are associated with schizophrenia and whether the structural alterations are restricted to either the magnocellular or parvocellular subdivisions of the LGN. Series of Nissl-stained sections spanning the LGN were obtained from 15 schizophrenic and 15 normal control subjects. The optical disector/ fractionator sampling method was used to estimate total neuronal number, total glial number and volume of the magnocellular and parvocellular subdivisions of the LGN. Cell number and volume of the LGN in schizophrenic subjects were not abnormal. Volume of both parvocellular and magnocellular layers of the LGN decreased with age. These findings do not support the hypothesis that early visual processing deficits are due to reduction of neuronal number in the LGN.

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Magnetic resonance imaging of the thalamus in male patients with schizophrenia

Cited by 36 publications

References 38 publications

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia

Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects

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