Magnetic Resonance Imaging of Schwannoma.

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma

“…While the overexpression of heparin-binding HGF and c-Met is associated with tumor metastasis and angiogenesis (Dong et al, 2001;Zeng et al, 2002), the mechanisms underlying these effects remain unclear. HGF has the capacity to mediate 'invasive growth', a hallmark of metastasis, due to coordinated activity of cell motility, the degradation of extracellular matrix ultimately leading to invasiveness and metastasis (Matsumoto et al, 1994;Galeazzi et al, 1997). While HGF-mediated activation of ERK is postulated to be important for tumorigenesis, there is a paucity of information on the activation of ERK mediated through FGF-2 signaling in SCCHN.…”

“…The overexpression of Met/HGF receptor was found in all tumor stages, but was significantly associated with enlarged or multiple (N2-N3) lymph node metastasis (Galeazzi et al, 1997), and the authors speculated that (Rong et al, 1994;Jeffers and Woude, 1996). As c-Met-HGF signaling is clinically associated with metastasis in SCCHN cells (Matsumoto et al, 1994;Cortesina et al, 2000), we performed experiments to determine whether HSulf-1 provided protection against invasion and metastasis as measured by transwell invasion/ migration assay in vitro. Our findings presented here indicate that HGF-mediated invasiveness and motility was significantly inhibited in HSulf-1-expressing clonal SCC012 cell lines compared to vector-transfected controls.…”