Magnetic Resonance Imaging of Primary Hepatic Malignancies in Patients With and Without Chronic Liver Disease: A Pictorial Review

Alexander, Lauren; Harri, Peter A.; Little, Brent P.; Moreno, Courtney C.; Mittal, Pardeep

doi:10.7759/cureus.1539

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…Thus, clinical features and techniques such as physical examination and CT/MRI scanning may need to be combined to differentiate CCA from HCC. 41 …”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

Sun¹,

Zhu²,

Wu³

et al. 2018

CMAR

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Background and aimSeveral dysregulated microRNAs (miRNAs) have been implicated in the pathogenesis of cholangiocarcinoma (CCA); however, small sample sizes and invariable research designs are limitations, hindering a thorough analysis of miRNAs as diagnostic and prognostic tools for CCA. This study aimed to systematically summarize the clinical value of miRNAs in human CCA both for all available miRNAs and single miRNA with multiple researches.MethodsPooled parameters included the area under the curve (AUC), sensitivity, specificity, and hazard ratios (HRs) to separately determine overall diagnostic and prognostic performance. Subgroup and sensitivity analyses were performed only in the event of heterogeneity. Thirty-four studies including 12 diagnostic studies and 22 prognostic studies were eligible for inclusion in this meta-analysis.ResultsWe observed that miR-21, miR-26, miR-483, miR-106a, miR-150, miR-192, and miR-194 were employed for distinguishing patients with CCA from healthy controls. Pooled sensitivity, specificity, and AUC were 0.82 (95% confidence interval [CI] 0.77–0.86), 0.83 (95% CI 0.75–0.89), and 0.88 (95% CI 0.85–0.91), respectively. Abnormal expression of miR-21, miR-26a, miR-192, miR-200c, miR-221, miR-29a, miR-191, miR-181c, miR-34a, miR-106a, miR-203, and miR-373 in patients was confirmed to associate with poor survival rate. Pooled HRs and 95% CIs were calculated using STATA, resulting in the pooled HR of 1.47 (95% CI 0.91–2.37) for overall survival (OS), 0.67 (95% CI 0.16–2.81) for disease-free survival (DFS), 2.31 (95% CI 1.59–3.36) for progression-free survival (PFS), and 2.68 (95% CI 0.88–8.15) for relapse-free survival (RFS). Thus, CCA patients with dysregulated miRNA expression were confirmed to have shorter OS, DFS, PFS, and RFS. Data regarding the diagnostic and prognostic roles of miR-21 suggested pooled diagnostic results of miR-21 for sensitivity, specificity, and AUC were 0.85 (95% CI 0.76–0.91), 0.92 (95% CI 0.81–0.97), and 0.93 (95% CI 0.91–0.95), respectively, suggesting better diagnostic performance of miR-21 compared with other miRNAs. Meanwhile, pooled prognostic result of miR-21 for HR was 1.88 (95% CI 1.41–2.51), indicating miR-21 could more appropriately predict shorter OS in patients with CCA.ConclusionmiRNAs may provide a new approach for clinical application, and miR-21 may be a promising biomarker for diagnosis and prognosis of CCA.

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“…Thus, clinical features and techniques such as physical examination and CT/MRI scanning may need to be combined to differentiate CCA from HCC. 41 …”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

Sun¹,

Zhu²,

Wu³

et al. 2018

CMAR

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“…Regrettably, most PHA cases detected with initial imaging are multiple nodules of varied sizes, large solitary masses, or mixed masses of predominant masses and nodules. Due to overlapping imaging features ( 14 ), it is even difficult for enhancement imaging to distinguish the malignant features of PHA from those of other malignancies (e.g., epithelioid hemangioendothelioma and hepatic cholangiocarcinoma). Even when it was accidentally discovered, PHA can be misdiagnosed as hemangioma at an early stage until it is surgically removed to stop excessive rapid growth ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Advanced diffuse hepatic angiosarcoma treated successfully with TACE and targeted immunotherapy: A case report

et al. 2023

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Primary hepatic angiosarcoma (PHA), a rare soft tissue tumor, accounts for only 2% of all liver malignancies. Pathologically challenging, PHA is difficult to be distinguished from other malignancies with ultrasound, Computed Tomography (CT), or Magnetic Resonance Imaging (MRI). Due to late diagnosis and resistance against traditional chemotherapy and/or radiotherapy, only 3% of PHA patients can survive up to two years after diagnosis. To our best knowledge, this case report presents the first case of an advanced diffuse PHA with ruptured hemorrhage that has been effectively treated with TACE and Anlotinib plus Camrelizumab. So far, the patient has received 10 cycles of treatment and is faring well. Latest MRI results show that the tumor has shrunk by 56% and can be assessed as a partial response (PR). This case report includes our experience in treating such a advanced malignancy, and we hope that larger studies on advanced PHA can better quantify the potential benefit.

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“…The application of T1‐weighed 3D gradient echo images and the frequent utilization of gadobenate dimeglumine, instead of standard gadolinium‐based contrast agents, for the characterization of hepatic lesions, are a case in point. 9 Thus, the implementation of a combined cardiac and hepatic MRI protocol may be challenging.…”

Section: Discussionmentioning

confidence: 99%

Atrial cholangiocarcinoma diagnosed by cardiac magnetic resonance imaging

et al. 2021

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Magnetic Resonance Imaging of Primary Hepatic Malignancies in Patients With and Without Chronic Liver Disease: A Pictorial Review

Cited by 4 publications

References 44 publications

Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

Advanced diffuse hepatic angiosarcoma treated successfully with TACE and targeted immunotherapy: A case report

Atrial cholangiocarcinoma diagnosed by cardiac magnetic resonance imaging

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