Magnetic resonance imaging of preterm brain injury

Counsell, Serena

doi:10.1136/fn.88.4.f269

Cited by 147 publications

(117 citation statements)

References 65 publications

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“…Articles confirmed that there are transitional changes in regions of the brain that we know are vulnerable to injury (16). We were able to successfully measure FMBV in all newborns at each time point.…”

Section: Transitional Basal Ganglia Perfusionsupporting

confidence: 48%

Basal ganglia perfusion in the preterm infant during transition

et al. 2016

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Background:The preterm brain is susceptible to changes in blood flow. Using power Doppler images, digital imaging techniques have been developed to measure the total amount of blood flow in a defined area, giving the index: fractional moving blood volume (FMBV). The aim of this study was to investigate temporal changes in basal ganglia perfusion during the transitional period after birth. Methods: Twenty-four preterm infants were examined with serial cranial ultrasounds at four time points during the first 48 h of life. FMBV was calculated using power Doppler images at each time point. results: All infants had analyzable data and FMBV was successfully calculated at all time points. Twenty-three of the 24 infants had an increasing trend in FMBV over time. The median FMBV increased from 17% at 6 h to 25% at 48 h. Oneway repeated measures ANOVA showed a significant increase in values at P < 0.001 at each of the four time points. conclusion: We have demonstrated changes in basal ganglia blood flow as the cerebral circulation adapts to extrauterine life. With further investigation, this technique may be useful in the assessment of preterm circulatory adaptation, either alone or in conjunction with other modes of evaluating cerebral blood flow.

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Section: Transitional Basal Ganglia Perfusionsupporting

confidence: 48%

Basal ganglia perfusion in the preterm infant during transition

et al. 2016

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“…MRI has become the modality of choice for investigating normal brain maturation as well as neonatal brain injury and developmental neurological disorders because of the modality's superior soft-tissue contrast, good spatial resolution and various physical parameters that can be used as contrast mechanisms [1][2][3][4][5][6][7][8][9][10][11][12]. The development of MR-compatible incubators and dedicated neonatal imaging coils has further enabled safe and fast acquisition of high-resolution anatomical and functional imaging of the neonatal brain with greater signal-to-noise ratio (SNR) [12].…”

Section: Introductionmentioning

confidence: 99%

“…T 1 -W and T 2 -W images are used routinely for monitoring development and identifying pathologies in the neonatal brain [2,[4][5][6][7][8][9][10][11][12][13][14]18]. These images are also used for segmentation and quantitative morphometric measurements in the developing brain [14,17,[30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

“…Frequently, however, sequences used for clinical diagnosis and morphometric measurements are acquired using different imaging protocols and experimental settings. While clinical scanning often involves spin-echo (SE) T 1 -W and T 2 -W sequences, having limited spatial resolution in one of the imaging directions [6,[9][10][11]18], isotropic high-resolution imaging is increasingly used for morphometric studies [7,11,31,34]. Developing appropriate sequences is almost always a trade-off between increasing scan time to improve scan quality and risking image degradation caused by patient movement.…”

Section: Introductionmentioning

confidence: 99%

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Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

et al. 2010

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Background T1-and T 2 -W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable. Objective To determine whether high-resolution T1-and T 2 -W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value. Materials and methods Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1-and T 2 -W highresolution sequences were optimized in terms of signal-tonoise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences. Results No differences were found between conventional and high-resolution T 1 -W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T 2 -W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T 2 -W images. Conclusion High-resolution T1-and T 2 -W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.R. Nossin-Manor (*)

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“…Brain magnetic resonance imaging was also performed at TEA in all infants using a Signa HDxt 1.5-Tesla imager (GE Healthcare, Buckinghamshire, UK) or a Sigma Horizon LX 1.5-Tesla imager (Yokokawa GE Medical, Tokyo, Japan) with conventional T1-weighted, T2-weighted, and fluid-attenuated inversion recovery imaging. All infants had normal findings according to the previously reported criteria (19).…”

Section: Articlesmentioning

confidence: 99%

Differences in amplitude among electrode locations on amplitude-integrated electroencephalograms in preterm infants

et al. 2012

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IntroductIon: To assess differences in amplitude among electrode locations on amplitude-integrated electroencephalograms (aeeGs) in preterm infants and change therein between preterm age and term-equivalent age (Tea), we investigated aeeGs in preterm infants at both 30-32 wk post-conceptional age (Pca) and Tea. Methods:The median values of upper-and lower-margin amplitudes were quantitatively calculated every 5 min (MedUMa5 and Med-LMa5, respectively), and peak, median, and bottom values were extracted at each location for the trans-frontal, trans-central, trans-occipital, fronto-central, and centro-occipital electrodes. results: In 38 clinically stable preterm infants studied, most measurement items showed significant differences among the electrode locations at both preterm age and Tea. at 30-32 wk Pca, the bottom of Med-LMa5 was significantly higher for the trans-frontal electrodes than for the trans-central electrodes. In contrast, all measurements for Med-LMa5 were significantly lower for the trans-frontal electrodes than for the trans-central electrodes. dIscussIon: amplitudes on aeeGs were significantly different among the electrode locations in preterm infants, and locational differences in amplitude changed between preterm age and Tea. It is necessary to understand the differences in amplitudes among the electrode locations on aeeGs in infants to appropriately evaluate them.

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Magnetic resonance imaging of preterm brain injury

Cited by 147 publications

References 65 publications

Basal ganglia perfusion in the preterm infant during transition

Basal ganglia perfusion in the preterm infant during transition

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

Differences in amplitude among electrode locations on amplitude-integrated electroencephalograms in preterm infants

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