Magnetic Resonance Imaging of Liver Metastasis

Karaosmanoğlu, Ali Devrim; Onur, Mehmet Ruhi; Ozmen, Mustafa; Akata, Deniz; Karçaaltıncaba, Muşturay

doi:10.1053/j.sult.2016.08.005

Cited by 48 publications

(38 citation statements)

References 109 publications

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“…All these properties of such nano-emulsions exactly coincide with the ones described above for the best MRI contrast agents ( e.g . T 1 -weighted gadoxetate disodium 17 ), and not yet fulfilled and available for CT. Our objective here is to increase the precision of the tools available for CT and micro-CT, generally being ca . 30% less precise than the MRI modalities 18 – 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, if this diagnosis approach is comparable with the one undertaken for the detection of liver metastasis 17 , the strength of MRI lies in several physical techniques giving complementary information, like (i) fat-suppressed T 2 -weihted imaged for determining the tumor location, (ii) contrast-enhanced T 1 -weighted images that show a ring enhancement around the tumor, and (iii) confirmed by diffusion-weighted sequence. Overall the clinic experience reported that MRI modality allows identifying metastasis unseen by US, CT or PET-CT 17 . Particularly, compared to contrast-enhanced MRI, the CT was recognized around 30% less precise 18 – 21 .…”

Section: Introductionmentioning

confidence: 99%

“…Since, the resolution and sensitivity of tumor detection is directly related to the tumor-to-liver contrast, as demonstrated in literature for hypo-vascular tumor, and a fortiori for post-vascular imaging 22 . Recent preclinical studies conducted on CT, T 1 - and T 2 -weighted imaging, emphasized that a lower detection limit of hepatic lesion is around 2–3 mm 17 , 23 – 25 . Therefore, the key factors that can improve the sensitivity of the tumor detection by CT may be linked to the concentration ofX-ray contrasting atoms (like iodine) in hepatocyte.…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions

Anton

Parlog

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et al. 2017

Sci Rep

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Hepatocellular carcinoma (HCC) is the only cancer for which non-invasive diagnosis is recognized by international guidelines. Contrast agent free ultrasound imaging, computed tomography (CT) and/or magnetic resonance imaging are techniques used for early detection and confirmation. Clinical evidence depicts that CT is 30% less precise as compared to MRI for detection of small tumors. In our work, we have reported some novel tools that can enhance the sensitivity and precision of CT applied to preclinical research (micro-CT). Our system, containing non-toxic nano-droplets loaded with iodine has high contrasting properties, liver and hepatocyte specificity and strong liver persistence. Micro-CT was performed on HCC model implanted in nude mice by intrahepatic injection. Contrast agent was administrated intravenously. This method allows an unprecedented high precision of detection, quantitative measurement of tumor volume and quantitative follow-up of the tumor development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions

Anton

Parlog

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et al. 2017

Sci Rep

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“…It was unexpected that lesion size did not affect the diagnostic performance of MRI in detecting CRLMs. Contemporary MRI has deficits in the detection of small metastatic liver lesions, especially those smaller than 3 mm 8 . In a previous meta-analysis 43 , the accuracy of MRI in detecting CRLM between lesions smaller and larger than 10 mm was significantly different.…”

Section: Covariates Subgroupsmentioning

confidence: 99%

“…The current diagnostic methods used for the evaluation of CRLM are heterogeneous. Among various imaging methods, such as computed tomography (CT), positron emission tomography (PET) combined with CT and ultrasonography (US), magnetic resonance imaging (MRI) has its superiority in LM detection due to its superior soft tissue resolution, multiple scan sequences, innovative MRI techniques, and the use of hepatocyte-specific contrast agents 8 . Recent studies have shown that liver MRI performed excellently in determining CRLM with both high sensitivity and specificity [9][10][11] .…”

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confidence: 99%

Diagnostic performance of magnetic resonance imaging for colorectal liver metastasis: A systematic review and meta-analysis

Mao

Chen

Wang

et al. 2020

Sci Rep

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the prognosis of colorectal cancer (cRc) is largely dependent on the early detection of hepatic metastases. With the advantages of nonradioactivity and the availability of multiple scanning sequences, the efficacy of magnetic resonance imaging (MRI) in the detection of colorectal liver metastases (cRLM) is not yet clear. We performed this meta-analysis to address this issue. pubMed, embase, and the cochrane Library were searched for studies reporting diagnostic performance of MRi for cRLM. Descriptive and quantitative data were extracted. The study quality was evaluated for the identified studies and a random effects model was used to determine the integrated diagnosis estimation. Metaregression and subgroup analyses were implemented to investigate the potential contributors to heterogeneity. As a result, seventeen studies were included for analysis (from the year 1996 to 2018), comprising 1121 patients with a total of 3279 liver lesions. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.90 (95% confidence intervals (CI): 0.81-0.95), 0.88 (0.80-0.92), and 62.19 (23.71-163.13), respectively. The overall weighted area under the curve was 0.94 (0.92-0.96). Using two or more imaging planes and a quantitative/semiquantitative interpretation method showed higher diagnostic performance, although only the latter demonstrated statistical significance (P < 0.05). Advanced scanning sequences with DWI and liver-specific contrast media tended to increase the sensitivity for cRLM detection. We therefore concluded that contemporary MRi has high sensitivity and specificity for screening CRLM, especially for those with advanced scanning sequences. Using two or more imaging planes and adopting a quantitative/semiquantitative imaging interpretation may further improve diagnosis. However, the MRi results should be interpreted with caution because of substantial heterogeneity among studies. Colorectal cancer (CRC) is one of the most common malignancies in the world. In recent decades, the mortality rate of CRC has decreased due to the development of diagnostic techniques and optimization of treatment strategies, including surgery, chemotherapy and palliative therapies 1. However, the incidence of CRC is increasing in the general population, especially in those younger than 40 years old 2. The prognosis of CRC patients is largely dependent on local tumor staging and the presence of distant metastasis. In those metastatic cases, the liver is the most frequently involved organ, followed by the lung 3,4. Almost one out of five patients present with liver metastases (LM) at the diagnosis of CRC 5 , and up to 50% of patients manifests LM at some time during the disease course 6 .

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Contrast-enhanced ultrasound compared with computed tomography, magnetic resonance imaging, and positron emission tomography-computed tomography for diagnosing liver metastases in people with newly diagnosed colorectal cancer

Lund

Nadarević

Bjerre

et al. 2020

Cochrane Database of Systematic Reviews

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Magnetic Resonance Imaging of Liver Metastasis

Cited by 48 publications

References 109 publications

Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions

Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions

Diagnostic performance of magnetic resonance imaging for colorectal liver metastasis: A systematic review and meta-analysis

Contrast-enhanced ultrasound compared with computed tomography, magnetic resonance imaging, and positron emission tomography-computed tomography for diagnosing liver metastases in people with newly diagnosed colorectal cancer

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