Magnetic Resonance Imaging of Granulomatous Inflammations

Wilson, J. Douglas; Castdlo, Mauricio

doi:10.1097/00002142-199400610-00006

Cited by 6 publications

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“…This disease responds to chemother- ble-2) and MRI in these cases showed diffuse, thick, meningeal enhancement at the basal cisterns. Meningeal lesions without parenchymal or vascular involvement were seen in 16% of cases while the combination of meningeal and parenchymal lesions was as common as 27% (Table-3 [7]. MRI of the brain often demonstrates a characteristic pattern of abnormal meningeal enhancement after the administration of intravenous gadolinium, typically at basal cisterns [8,9].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging in Intracranial Tuberculosis

Indrajit

Ganesan

2001

Medical Journal Armed Forces India

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Tuberculosis (TB) is still a major cause of serious illness in many parts of the world. Intracranially, TB manifests itself variably as meningitis, tuberculoma and tubercular abscess [II. Although its appearance on MR is not absolutely specific, it is important in the proper clinical setting to recognize the range of possible patterns that can be observed on images £2]. Magnetic Resonance Imaging (MRI) has emerged as a quality imaging tool aiding in the diagnostic evaluation of intracranial TB variably displaying meningeal, parenchymal, osseous and craniovertebrallesions. The MRI characteristics of 18 cases of intracranial TB were reviewed. Results: Multiple lesions occured with a slightly higher incidence at 61 %. In all, 11 patients (61 %) presented with meningitis. Meningeal lesions without parenchymal or vascular involvement were seen in 16% of cases. 2 patients had extension of enhancing exudates into the spinal subarachnoid spaces. While 6 patients had focal intra-axial tuberculomas, representing 33% cases, 3 patients presented with infarcts. 1 patient presented with haemorrhagic infarct at right middle cerebral artery territory while two other showed multiple small infarcts. Hydrocephalus was identified in 4 patients and epidural lesions were noted in 2 cases. MRI should be considered as the imaging modality of choice for patients with suspected intracranial TB.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging in Intracranial Tuberculosis

Indrajit

Ganesan

2001

Medical Journal Armed Forces India

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“…Tuberculosis is, in some parts of the world, a relatively common. [ 33 34 ] As tuberculosis is a common disease in our part of the earth we were not surprised by the report of tuberculosis from a lesion from CS.…”

Section: Discussionmentioning

confidence: 96%

Microsurgical management of benign lesions interior to the cavernous sinus: A case series

Chowdhury

Haque

2017

Asian J Neurosurg

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Background:Benign lesion interior to the cavernous sinus (CS) is very rare.Objective:In this series we found nonneoplastic lymphatic aggregation and osteoclastoma inside the CS which is very rare and probably not reported in literature. One interesting postoperative complaint of feeling of tickling down of warm water under the skin forehead was found in the patient of inflammatory disease of CS which is not reported in literature. Here we also describe our experiences of microsurgical management of series of benign lesions inside the CS.Materials and Methods:Benign mass originated from the content of CS or inner side of walls of CS, confirmed peroperatively were included in this series. Prospectively recorded data of microsurgical management was retrogradely studied.Results:Total number of patient was 12. Patient's age range was 30–60 years. Follow-up range was 60 months to 19 months. Three was nonneoplastic lesion (tuberculosis, inflammatory and nonneoplastic lymphoid infiltration). Among the 9 neoplastic lesions, two hemangiomas, two meningiomas, three 6th nerve schwannomas, one osteoclastoma and one epidermoid tumor. Middle cranial fossa-subtemporal extradural approach was used in 9 cases and in two cases extended middle fossa zygomatic approach. New postoperative 3rd nerve palsy developed in 5 cases all recovered completely except one. In seven patients 6th nerve palsy developed after operation; only one recovered. Postoperatively simultaneous 3rd, 4th and 6th nerve palsy developed in four cases. One interesting postoperative complaint of feeling of tickling down of warm water under the skin of left sided forehead was found in the patient of inflammatory disease of CS. Mortality was nil. Total resection was done in 9 cases. There was no recurrence till last follow-up.Conclusion:Though decision for microsurgical removal of such lesions is not straight forward. Probably microsurgery is the best option in treating such benign lesions though it may associate with some permanent cranial nerve palsy.

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“…In humans, CNS infection with Mtb results in inflammatory granulomatous responses in the meninges or brain parenchyma (Jinkins, 1991; Molavi and LeFrock, 1985; Wilson and Castillo, 1994). In the case of tuberculosis meningitis, the subarachnoid space is filled with inflammatory cells and fibroblasts, and granulomas can also be found along the cerebral blood vessels (Molavi and LeFrock, 1985).…”

Section: Discussionmentioning

confidence: 99%

Intracerebral Mycobacterium bovis bacilli Calmette–Guerin infection-induced immune responses in the CNS☆

Lee¹,

Ling²,

Kosmalski³

et al. 2009

Journal of Neuroimmunology

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To study whether cerebral mycobacterial infection induces granuloma and protective immunity similar to systemic infection, we intracerebrally infected mice with Mycobacterium bovis bacilli Calmette-Guerin. Granuloma and IFN-γ+CD4+ T cell responses are induced in the central nervous system (CNS) similar to periphery, but the presence of IFN-γIL-17 double-positive CD4+ T cells is unique to the CNS. The major CNS source of TNF-α is microglia, with modest production by CD4+ T cells and macrophage. Protective immunity is accompanied by accumulation of Foxp3+CD4+ T cells and PD-L2+ dendritic cells, suggesting that both inflammatory and anti-inflammatory responses develop in the CNS following mycobacterial infection.

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Magnetic Resonance Imaging of Granulomatous Inflammations

Cited by 6 publications

References 0 publications

Magnetic Resonance Imaging in Intracranial Tuberculosis

Magnetic Resonance Imaging in Intracranial Tuberculosis

Microsurgical management of benign lesions interior to the cavernous sinus: A case series

Intracerebral Mycobacterium bovis bacilli Calmette–Guerin infection-induced immune responses in the CNS☆

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