Magnetic resonance imaging of endolymphatic hydrops in Ménière's disease: A comparison of the diagnostic value of multiple scoring methods

Xiao, Heng; Guo, Xiaojing; Cai, Huimin; Lin, Jianwei; Lin, Chenxin; Fang, Zhipeng; Ye, Shengnan

doi:10.3389/fneur.2022.967323

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…While, some considered that the inner ear structural assignment method is a more sensitive and specific diagnostic scoring method for diagnosis. [64] Barath et al [65] (2014) evaluated the enlargement of endolymphatic spaces separately within the cochlea and vestibule from grade 0, I, and II on a 3-grade scale. Bernaerts et al [66] modified the scale and took a saccule larger than the utricle; the boundary between the 2 was maintained as grade I in 2019.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Wang

Zhang

et al. 2023

Medicine

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Background: Meniere's disease (MD) is a clinical condition characterized by endolymphatic hydrops. Persistent symptoms negatively affect patients mood, and the underlying etiology remains unclear. It is necessary to comprehensively understand the relevant publications, review the history and current status of research, and analyze hotspots and frontiers of research on MD.Methods: We retrieved literature on Meniere's disease from 2003 to 2022 from the Web of Science database and extracted the data. Data visualization and analysis was conducted using Cite Space, VOS viewer, an online web tool, and Microsoft Office Power Point 2019.Results: In total, 2847 publications were analyzed. The number of annual publications was relatively stable, with an accelerated upward trend over the past 5 years. The country with the most publications was USA (751, 26.38%), while the University of Munich contributed more publications than any other institution (117, 4.11%). The article titled "Diagnostic criteria for Meniere's disease" by Lopez-Escamez J et al in 2015 was the most cited and co-cited publication, and also had the top co-cited references with the strongest citation bursts. Naganawa S was the author with the most publications (85, 2.99%). The top 3 journals and co-cited journals were Otology Neurotology, Acta Oto Laryngologica, and Laryngoscope. Recently, the key theme words were "sensorineural hearing loss," "therapy," "intratympanic injection method," "vestibular-evoked myogenic potentials," "vestibular migraine," "magnetic resonance imaging," and "meniere's disease." Conclusions:The US has the largest number of publications and research institutions, many European countries have highquality journals, and Japan has the highest number of scholars. The international opinion on Meniere's disease is relatively uniform. The stepped-therapy for MD is scientific and clear. Intratympanic injection of steroids and intratympanic injection of gentamicin are commonly used, but steroids are considered safer. Saccular dysfunction may be more common in patients with MD than in those with utricular dysfunctions. It is worth paying attention to study the relationship between MD and vestibular migraine through headache. Progress in magnetic resonance imaging technology is still required for the imaging diagnosis of MD.

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Wang

Zhang

et al. 2023

Medicine

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“…Those that exist, such as vestibular evoked myogenic potentials or magnetic resonance imaging (Gluth 2020), can be expensive, variable in sensitivity, and time-consuming. In addition, successful application of the magnetic resonance imaging for diagnosis of hydrops requires special protocols involving contrast-enhancement and sophisticated scoring methods (Han et al 2022; Mavrommatis et al 2022; Xiao et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

2023

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Objectives: Endolymphatic hydrops (EH), a hallmark of Meniere disease, is an inner-ear disorder where the membranes bounding the scala media are distended outward due to an abnormally increased volume of endolymph. In this study, we characterize the joint-otoacoustic emission (OAE) profile, a results profile including both distortion- and reflection-class emissions from the same ear, in individuals with EH and speculate on its potential utility in clinical assessment and monitoring. Design: Subjects were 16 adults with diagnosed EH and 18 adults with normal hearing (N) matched for age. Both the cubic distortion product (DP) OAE, a distortion-type emission, and the stimulus-frequency (SF) OAE, a reflection-type emission, were measured and analyzed as a joint OAE profile. OAE level, level growth (input/output functions), and phase-gradient delays were measured at frequencies corresponding to the apical half of the human cochlea and compared between groups. Results: Normal hearers and individuals with EH shared some common OAE patterns, such as the reflection emissions being generally higher in level than distortion emissions and showing more linear growth than the more strongly compressed distortion emissions. However, significant differences were noted between the EH and N groups as well. OAE source strength (a metric based on OAE amplitude re: stimulus level) was significantly reduced, as was OAE level, at low frequencies in the EH group. These reductions were more marked for distortion than reflection emissions. Furthermore, two significant changes in the configuration of OAE input/output functions were observed in ears with EH: a steepened growth slope for reflection emissions and an elevated compression knee for distortion emissions. SFOAE phase-gradient delays at 40 dB forward-pressure level were slightly shorter in the group with EH compared with the normal group. Conclusions: The underlying pathology associated with EH impacts the generation of both emission types, reflection and distortion, as shown by significant group differences in OAE level, growth, and delay. However, hydrops impacts reflection and distortion emissions differently. Most notably, DPOAEs were more reduced by EH than were SFOAEs, suggesting that pathologies associated with the hydropic state do not act identically on the generation of nonlinear distortion at the hair bundle and intracochlear reflection emissions near the peak of the traveling wave. This differential effect underscores the value of applying a joint OAE approach to access both intracochlear generation processes concurrently.

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Assessing the optimal MRI descriptors to diagnose Ménière’s disease and the added value of analysing the vestibular aqueduct

Connor,

Pai,

Touska

et al. 2024

Eur Radiol

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Objectives To evaluate the diagnostic performance and reliability of MRI descriptors used for the detection of Ménière’s disease (MD) on delayed post-gadolinium MRI. To determine which combination of descriptors should be optimally applied and whether analysis of the vestibular aqueduct (VA) contributes to the diagnosis. Materials and methods This retrospective single centre case-control study evaluated delayed post-gadolinium MRI of patients with Ménièriform symptoms examined consecutively between Dec 2017 and March 2023. Two observers evaluated 17 MRI descriptors of MD and quantified perilymphatic enhancement (PLE) in the cochlea. Definite MD ears according to the 2015 Barany Society criteria were compared to control ears. Cohen’s kappa and diagnostic odds ratio (DORs) were calculated for each descriptor. Forward stepwise logistic regression determined which combination of MRI descriptors would best predict MD ears, and the area under the receiver operating characteristic curve for this model was measured. Results A total of 227 patients (mean age 48.3 ± 14.6, 99 men) with 96 definite MD and 78 control ears were evaluated. The presence of saccular abnormality (absent, as large as or confluent with the utricle) performed best with a DOR of 292.6 (95% confidence interval (CI), 38.305–2235.058). All VA descriptors demonstrated excellent reliability and with DORs of 7.761 (95% CI, 3.517–17.125) to 18.1 (95% CI, 8.445–39.170). Combining these saccular abnormalities with asymmetric cochlear PLE and an incompletely visualised VA correctly classified 90.2% of cases (sensitivity 84.4%, specificity 97.4%, AUC 0.938). Conclusion Either absent, enlarged or confluent saccules are the best predictors of MD. Incomplete visualisation of the VA adds value to the diagnosis. Clinical relevance statement A number of different MRI descriptors have been proposed for the diagnosis of Ménière’s disease, but by establishing the optimally performing MRI features and highlighting new useful descriptors, there is an opportunity to improve the diagnostic performance of Ménière’s disease imaging. Key Points • A comprehensive range of existing and novel vestibular aqueduct delayed post-gadolinium MRI descriptors were compared for their diagnostic performance in Ménière’s disease. • Saccular abnormality (absent, confluent with or larger than the utricle) is a reliable descriptor and is the optimal individual MRI predictor of Ménière’s disease. • The presence of this saccule descriptor or asymmetric perilymphatic enhancement and incomplete vestibular aqueduct visualisation will optimise the MRI diagnosis of Ménière’s disease.

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Magnetic resonance imaging of endolymphatic hydrops in Ménière's disease: A comparison of the diagnostic value of multiple scoring methods

Cited by 5 publications

References 24 publications

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

Assessing the optimal MRI descriptors to diagnose Ménière’s disease and the added value of analysing the vestibular aqueduct

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