Magnetic Resonance Imaging of Cutaneous Melanocytic Lesions

Zemtsov, Alexander; Lorig, Ronald; Bergfield, Wilma F.; Bailin, Philip L.; Ng, Thian C.

doi:10.1111/j.1524-4725.1989.tb01174.x

Cited by 42 publications

(26 citation statements)

References 7 publications

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“…It would thus be easier to evaluate the resection edges, particularly in areas of the body in which surgery is more difficult and mutilating [19]. MRI would allow the follow-up of cutaneous lesions and the evaluation of therapeutic efficiency.…”

Section: Study Of the Intra-and Interobserver Reproducibilitymentioning

confidence: 99%

Feasibility study of 3-T MR imaging of the skin

et al. 2009

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The purpose of this study was to assess the quality of 3-T magnetic resonance (MR) imaging of the skin, to describe skin anatomy at 3 T and to discuss future prospects of skin MRI. A 7-cm single-element surface receiver coil was developed for our 3-T MRI system. Thin sections were obtained with a three-dimensional FIESTA acquisition sequence and a spin-echo T1-weighted sequence (SET1). Prospective analysis was performed twice by two radiologists independently. Thirty-six healthy volunteers were included and underwent MRI on the face and the calf. Image quality was assessed regarding visibility of skin layers and quantification of artefacts. High field strength MR enables imaging of the skin with a high spatial in-plane resolution (87-180 microm), the total examination lasting 15-20 min. Image quality was excellent for the calf (mean SET1 quality = 96%) with a high intra- and interobserver correlation (SET1 kappa coefficient concerning visibility of epidermis, dermis and hypodermis > or = 0.84). Motion artefacts resulted in a small loss of quality and reproducibility for the face. In conclusion, 3-T MR allows high spatial resolution imaging of the skin and can potentially provide an accurate noninvasive means of analysing the skin.

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Section: Study Of the Intra-and Interobserver Reproducibilitymentioning

confidence: 99%

Feasibility study of 3-T MR imaging of the skin

et al. 2009

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“…The aim of most clinical applications of MR imaging of the skin has been to differentiate among the different kinds of skin tumour. Melanomas and pigmented tumours were first explored owing to their high signal intensity on T 1 -weighted images (31,32). However, the study on gadolinium uptake failed to distinguish between benign and malignant tumors (33,34).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Advances in MR imaging of the skin

2006

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MR imaging of the skin is challenging because of the small size of the structures to be visualized. By increasing the gradient amplitude and/or duration, skin layers can be visualized with a voxel size of the order of 20 mm, clearly the smallest obtained for in vivo images in a whole-body imager. Currently, the gradient strength of most commercial systems enables acquisition of such a small voxel size, and the main difficulty has thus become to achieve sufficient detection sensitivity. The signal-to-noise ratio (SNR) can be increased either by increasing the magnetic field strength or by minimizing noise with small coils; cooling copper coils or superconducting coils can enhance the SNR by a factor of 3 or more. MR imaging, because of the large number of parameters it is able to measure, can provide more than the microscopic architecture of the skin: physical parameters such as relaxation times, magnetization transfer or diffusion, and chemical parameters such as the water and fat contents or phosphorus metabolism. In spite of the amount of information they have provided to date, MR imaging and spectroscopy have had limited clinical applications, mainly because cutaneous pathologies are easily accessible to the naked eye and surgery. However, MR technologies indeed represent powerful research tools to study normal and diseased skin.

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“…Konform zu anderen Autoren [35] stellten sich die in dieser Studie untersuchten Melanome aufgrund ihres Melaningehalts [31] und möglicherweise aufgrund des erhöhten Eisengehalts als Resultat der nekrotischen Tumoranteile hyperintens dar. Mihara et al [24] postulieren, daß postkontrast-T1-gewich- Mäurer et al [22] geben jedoch an, daß der Nutzen der Analyse von SRV und KRV zur Differenzierung zwischen malignen und benignen melaninenthaltenden Tumoren der Haut limitiert ist.…”

Section: Introductionunclassified

“…In unserer Studie konnten erwartungsgemäß keine toxischen Nebenwirkungen beobachtet werden, die Mäuse zeigten nach Abschluß des Experiments jedoch eine Grünfärbung der Haut und des Urins. [35] führt diese Charakteristika (Inhomogenitäten, peritumorales Ödem) als Kriterien für die Differenzierung zwischen benignen und malignen melanotischen Hauttumoren auf, steht damit jedoch im Gegensatz zu Kransdorf et al [20].…”

Section: Introductionunclassified