Magnetic Resonance Imaging of Carotid Atherosclerosis

Kerwin, William S.; Xu, Dongxiang; Liu, Fei; Saam, Tobias; Underhill, Hunter R.; Takaya, Norihide; Chu, Baocheng; Hatsukami, Thomas S.; Yuan, Chun

doi:10.1097/rmr.0b013e3181598d9d

Cited by 191 publications

(180 citation statements)

References 41 publications

Supporting

Mentioning

177

Contrasting

Order By: Relevance

“…17,18 Two experienced readers registered and segmented the images using CASCADE, a custom designed analysis software. 19 Lumen and outer wall boundaries were outlined for each image slice, measuring the resulting lumen, outer wall, and total vessel areas. If detected, lipid-rich necrotic core and calcification boundaries were also outlined following histology-validated imaging criteria 11 and their percentage of the wall was computed (%LRNC and %CA, respectively).…”

Section: Iia Magnetic Resonance Imaging Datamentioning

confidence: 99%

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

et al. 2012

Self Cite

View full text Add to dashboard Cite

Purpose: Arterial distensibility is a marker that can measure vessel wall functional and structural changes resulting from atherosclerosis with applications including estimation of mechanical properties of the wall. We sought to assess the feasibility of using magnetic resonance imaging (MRI) to include wall distensibility in the characterization of atherosclerotic carotid arteries and to analyze the relationship between distensibility and morphological and compositional plaque features. Methods: Five healthy volunteers were imaged with a multiple-slice CINE MR sequence twice, within 24 h, to determine the interscan reproducibility of distensibility measurements. Twenty-one subjects with >15% carotid stenosis and the five healthy volunteers were imaged using a multicontrast carotid MRI protocol to characterize arterial wall morphology and composition. Normalized wall index (wall area/total vessel area), maximum wall thickness and, if present, percentages of wall area occupied by calcification and lipid-rich necrotic core were determined. A multiple-slice CINE MR sequence was added to the multicontrast protocol to measure the distensibility coefficient (DC) at several locations spanning the bifurcation. The intraclass correlation coefficient (ICC) and the coefficient of variation were used to assess the reproducibility of DC measurements made on the healthy subjects. The DC was compared between arterial segments and between the healthy and diseased groups. Furthermore, within the diseased group, DC was correlated to plaque morphology and composition at each location as well as that averaged over the plaque. Results: Distensibility measurements were highly reproducible: ICC (95% confidence interval) was 0.998 (0.96-1.0) for the common carotid segment and 0.990 (0.92-1.0) for the internal carotid segment. In healthy volunteers, we found significantly higher distensibility in the common segment of the carotid artery compared to the internal carotid segment (mean ± SD = 4.56 ± 1.02 versus 3.56 ± 1.32 × 10 −5 /Pa; p < 0.05). However, no segmental differences were seen in the diseased group (3.25 ± 1.84 versus 3.26 ± 1.60 × 10 −5 /Pa; p = 0.607). Location-to-location changes in DC were not found to correlate to changes in the local plaque morphology or composition nor were average DC found to be associated with aggregate plaque features.Conclusions: These results demonstrate the feasibility of MRI to measure distensibility in the carotid artery and to presumably detect changes in distensibility due to age and/or disease. The results suggest that the effect of atherosclerosis on local distensibility may not strongly depend upon the specific underlying plaque features in mild to moderate stenotic carotid lesions though more diffuse or nonlocal changes in arterial distensibility could not be ruled out.

show abstract

Section: Iia Magnetic Resonance Imaging Datamentioning

confidence: 99%

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…A custom-designed image analysis software (CASCADE) (20) was used to outline the lumen area (LA) and total vessel area (TVA) as well as plaque components. Wall area (WA ¼ TVA -LA), normalized wall index (NWI ¼ WA/TVA), mean wall thickness (MWT), and maximal wall thickness (MaxWT) measures were derived from the LA and TVA outlines.…”

Section: Image Analysismentioning

confidence: 99%

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Yarnykh

Hatsukami

et al. 2009

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Purpose: To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol. Materials and Methods:A total of 20 patients with carotid stenosis >15% identified by duplex ultrasound were recruited for two independent 3T MRI (Philips) scans within one month. A multicontrast protocol including five MR sequences was applied: TOF, T1-/T2-/PD-weighted and magnetization-prepared rapid acquisition gradientecho (MP-RAGE). Carotid artery morphology (wall volume, lumen volume, total vessel volume, normalized wall index, and mean/maximum wall thickness) and plaque component size (lipid rich/necrotic core, calcification, and hemorrhage) were measured over two time points.Results: After exclusion of images with poor image quality, 257 matched locations from 18 subjects were available for analysis. For the quantitative carotid morphology measurements, coefficient of variation (CV) ranged from 2% to 15% and intraclass correlation coefficient (ICC) ranged from 0.87 to 0.99. Except for maximum wall thickness (ICC ¼ 0.87), all ICC were larger than 0.90. For the quantitative plaque composition measurements, the ICC of the volume and relative content of lipid rich/necrotic core and calcification were larger than 0.90 with CV ranging from 22% to 32%. Conclusion:The results from the multicontrast high-resolution 3T MR study show high reliability for carotid morphology and plaque component measurements. 3T MRI is a reliable tool for longitudinal clinical trials, with shorter scan time compared to 1.5T.

show abstract

“…Only consecutive images of an artery with ImQ Ն2 were interpreted. Image-analysis software (CASCADE, 13 Seattle, Washington) was used to draw the lumen and outer wall boundaries. Lumen volume, wall volume, and total vessel volume (lumen volume ϩ wall volume) were used to calculate percentage wall volume (wall volume/total vessel volume ϫ 100%), a measure of plaque burden similar to that proposed by Nissen et al 14 during imaging investigations of the coronary arteries.…”

Section: Image Analysismentioning

confidence: 99%

Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis

Dong

Underhill

et al. 2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

Magnetic Resonance Imaging of Carotid Atherosclerosis

Abstract: Automated analysis tools are capable of providing accurate and reproducible measurements of carotid atherosclerotic burden and composition when compared with manually outlined results.

Cited by 191 publications

References 41 publications

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis

Contact Info

Product

Resources

About