volume 99, issue 2, P232-240 1997
DOI: 10.1542/peds.99.2.232
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V. W. Swayze, V. P. Johnson, J. W. Hanson, J. Piven, Y. Sato, J. N. Giedd, D. Mosnik, N. C. Andreasen

Abstract: Patients with classic FAS have a high incidence of midline brain anomalies. This finding is consistent with the concept that the midline CNS is a developmental field that is particularly susceptible to the teratogenic effects of alcohol. Furthermore, patients with more severe facial dysmorphologic characteristics are more likely to have midline brain anomalies. In addition, we observed a high incidence of micrencephaly with a wide range of severity.