Magnetic resonance imaging of bone destruction in rheumatoid arthritis: comparison with radiography

Poleksic, L.; Zdravkovic, D.; Jablanović, Dragoslav; Watt, Iain; Bačić, Goran

doi:10.1007/bf00197138

Cited by 54 publications

(22 citation statements)

References 11 publications

(30 reference statements)

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“…MRI detected erosions in 92 finger joints (20%; 26 patients) in group 1 that were not detected by conventional radiography. Other investigators as well as our group have reported similar results for the wrists (24,25,(37)(38)(39), shoulders (40)(41)(42)(43), and knees of RA patients (26,(44)(45)(46) and for the sacroiliac joints of patients with spondylarthropathies (6,7,9).…”

Section: Backhaus Et Alsupporting

confidence: 72%

“…In contrast to conventional radiography, MRI depicts early inflammatory changes in the joint, especially synovitis and tenosynovitis. Furthermore, MRI detects erosions earlier than conventional radiography (13,(23)(24)(25)(26)(27). The objective of the present study was to perform a prospective comparative investigation of clinical signs and findings on conventional radiography, 3-phase bone scintigraphy, ultrasound, and MRI using precontrast and dynamic postcontrast examination of the dominant hand in patients with arthritis who do not have typical radiologic signs of destructive arthritis in that hand and to compare the findings with those in patients with typical radiologic signs of erosions.…”

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confidence: 99%

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Arthritis of the finger joints: A comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging

Backhaus

Kamradt

Sandrock

et al. 1999

Arthritis & Rheumatism

610

283

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Objective. A prospective study was performed comparing conventional radiography, 3-phase bone scintigraphy, ultrasound, and magnetic resonance imaging (MRI) with precontrast and dynamic postcon-trast examinations in 60 patients with various forms of arthritis including rheumatoid arthritis (RA), spondyl-arthropathy, and arthritis associated with connective tissue disease. Methods. A total of 840 finger joints were examined clinically and by all 4 imaging methods. Experienced investigators blinded to the clinical findings and diagnoses analyzed all methods independently of each other. The patients were divided into 2 groups. Group 1 included 32 patients (448 finger joints) without radio-logic signs of destructive arthritis (Larsen grades 0-1) of the evaluated hand and wrist and group 2 included 28 patients (392 finger joints) with radiographs revealing erosions (Larsen grade 2) of the evaluated hand and/or wrist. Results. Clinical evaluation, scintigraphy, MRI, and ultrasound were each more sensitive than conventional radiography in detecting inflammatory soft tissue lesions as well as destructive joint processes in arthritis patients in group 1. All differences were statistically significant. We found ultrasound to be even more sensitive than MRI in the detection of synovitis. MRI detected erosions in 92 finger joints (20%; 26 patients) in group 1 that had not been detected by conventional radiography. Conclusion. Our data indicate that MRI and ultrasound are valuable diagnostic methods in patients with arthritis who have normal findings on radiologic evaluation.

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Section: Backhaus Et Alsupporting

confidence: 72%

mentioning

confidence: 99%

Arthritis of the finger joints: A comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging

Backhaus

Kamradt

Sandrock

et al. 1999

Arthritis & Rheumatism

610

283

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“…Bone oedema is another important MRI feature in inflammatory joint diseases [5,7,8,9,10,11], and it has been suggested to be a forerunner of bone erosion [9]. Bone oedema has been observed in more than half of the patients with rheumatoid arthritis [9,12].…”

mentioning

confidence: 99%

MRI of the wrist and finger joints in inflammatory joint diseases at 1-year interval: MRI features to predict bone erosions

et al. 2001

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The aim of this study was to assess the ability of MRI determined synovial volumes and bone marrow oedema to predict progressions in bone erosions after 1 year in patients with different types of inflammatory joint diseases. Eighty-four patients underwent MRI, laboratory and clinical examination at baseline and 1 year later. Magnetic resonance imaging of the wrist and finger joints was performed in 22 patients with rheumatoid arthritis less than 3 years (group 1) who fulfilled the American College of Rheumatology (ACR) criteria for rheumatoid arthritis, 18 patients with reactive arthritis or psoriatic arthritis (group 2), 22 patients with more than 3 years duration of rheumatoid arthritis, who fulfilled the ACR criteria for rheumatoid arthritis (group 3), and 20 patients with arthralgia (group 4). The volume of the synovial membrane was outlined manually before and after gadodiamide injection on the T1-weighted sequences in the finger joints. Bones with marrow oedema were summed up in the wrist and fingers on short-tau inversion recovery sequences. These MRI features was compared with the number of bone erosions 1 year later. The MR images were scored independently under masked conditions. The synovial volumes in the finger joints assessed on pre-contrast images was highly predictive of bone erosions 1 year later in patients with rheumatoid arthritis (groups 1 and 3). The strongest individual predictor of bone erosions at 1-year follow-up was bone marrow oedema, if present at the wrist at baseline. Bone erosions on baseline MRI were in few cases reversible at follow-up MRI. The total synovial volume in the finger joints, and the presence of bone oedema in the wrist bones, seems to be predictive for the number of bone erosions 1 year later and may be used in screening. The importance of very early bone changes on MRI and the importance of the reversibility of these findings remain to be clarified.

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“…Although these techniques have a higher sensitivity for disease detection, our MR-based method with the use of FR-targeted Gd-chelates has the advantage of a higher spatial resolution, which allows a better delineation of individual joint components (14,20,22,(37)(38)(39)(40)(41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, MR is not associated with any radiation exposure. Although standard gadopentetate-enhanced MR imaging provides a high sensitivity for the detection of arthritis, it provides only a limited specificity (17)(18)(19)(20), because the enhancement of inflammatory tissues overlaps with the enhancement patterns of normal joints and other pathologic processes (17,21,22). New FR-based gadolinium (Gd) chelates are expected to improve the sensitivity and specificity of MR imaging for the diagnosis of arthritis, similar to the radiotracers mentioned above.…”

Section: Introductionmentioning

confidence: 96%

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Saborowski

Simon

Raatschen

et al. 2007

Contrast Media & Molecular

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The purpose of this study was to investigate if the new folate receptor-targeted Gd-chelate P866 may enhance immune-mediated arthritis. A monoarthritis was induced in the right knee of 15 Sprague-Dawley rats. MR imaging of both knees was performed at 2 T before and up to 2 h and 24 h after injection (p.i.) of P866 (n = 3 dose finding study and n = 6, 0.02 mmol Gd/kg), the non-FR targeted P866 analog P1001 (n = 3 at 24 h after P866-administration, 0.02 mmol Gd/kg) or Gd-DOTA (n = 6, 0.1 mmol Gd/kg). Pulse sequences comprised T(1)-SPGR 80 degrees /50 ms/1.7 ms (flip angle/TR/TE) and inversion recovery 10 degrees /3000 ms/1500 ms/50-3050, 10 000 ms (flip angle/TR/TE/TI) sequences. DeltaSI-data and T(1)-relaxation times of arthritic knees and contralateral normal knees were determined. Folate receptor expression was confirmed with histopathology. All three contrast agents showed an initial perfusion effect with significantly higher DeltaSI-data of arthritic knees compared with normal knees (p < 0.05). In addition, P866, but not P1001 or Gd-DOTA, showed a prolonged enhancement of the synovitis. Compared with precontrast values, the T(1)-relaxation times of inflamed synovia were significantly decreased at 2 h p.i. of P866 (p < 0.05), but not P1001 or Gd-DOTA (p > 0.05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor-targeted Gd-chelate P866 in this arthritis model.

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Magnetic resonance imaging of bone destruction in rheumatoid arthritis: comparison with radiography

Cited by 54 publications

References 11 publications

Arthritis of the finger joints: A comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging

Arthritis of the finger joints: A comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging

MRI of the wrist and finger joints in inflammatory joint diseases at 1-year interval: MRI features to predict bone erosions

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

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