Magnetic Resonance Imaging (MRI) and Visual Evoked Potentials (VEPs) of Occipital Region in Patients with Schizophrenia and Migraine Headache

Abstract

Aim:To examine the morphologic variations of occipital sulci patterns in patients with schizophrenia and migraine haeadache regarding gender and laterality as well as damage of visual pathway in patients with schizophrenia using magnetic resonance imagining (MRI) and visual evoked potentials (VEPs).Methods:This study included 80 patients and brain scans and visual evoked potential responses recorded over the occipital cortex were performed to analyze the occipital region of both hemispheres. Average total volumes of both hemispheres and average values of amplitude of the healthy population for the comparasion were used.Results:There was statistically significant difference between subjects considering gender (p=0.012). Parameters of parieto-occipital fissure (p=0.0314) showed statistically significant positive correlation with P100 amplitude (p=0.05), body of the calcarine sulcus (p=0.0213) had significant positive correlation with P100 amplitude (p=0.04), retro calcarine sulcus (p=0.0516) and P100 amplitude (p=0.03) showed statistically significant difference only of left hemisphere in male patients with schizophrenia with shallower depth of the sulcus and P100 amplitude reduction.Conclusion:Schizophrenia is associated with the volume changes of the occipital lobe. Comparative analysis of morphologic differences in the gray matter of occipital lobe using MRI and VEPs revealed changes especially of the left hemisphere (shallower depth of sulcus and P100 amplitude reduction) only among a group of male patients.

The electrophysiological assessment of visual function in Multiple Sclerosis

“…Although a standard VEP waveform is now accepted for each VEP technique ( Odom et al, 2016 ), the significant inter-subject variability in VEP amplitude ( Ciganek, 1969 , Shors et al, 1986 , Werre and Smith, 1964 ) and somewhat lesser degree of intra-subject variability ( Fagan et al, 1984 ) largely restricts the clinical use of amplitude measures to the assessment of inter-ocular differences. The cause of the large amplitude variance stems from inter-subject differences in skull thickness ( Hagemann et al, 2008 , Myslobodsky et al, 1989 ) and cortical folding of the primary visual cortex ( Sulejmanpasic and Drnda, 2017 ) ( Fig. 1 ).…”

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

“…Varying the frequency of visual stimulation, the examiner could elicit cortical responses with transient (T-VEP) or steady-state (SS-VEP) waveforms. Both these VEP analyses have been used to characterize migraine patients [ 6 , 13 , 14 ], even in combination with neuroimaging [ 5 , 15 ].…”

Altered Processing of Visual Stimuli in Vestibular Migraine Patients Between Attacks: A Combined VEP and sLORETA Study

“…As visual symptoms and photophobia are common clinical features of VM, we hypothesized that patients with VM have abnormally sensitive low-level visual processing capabilities. A primary approach to analyzing visual processing integrity is the use of visual evoked potentials (VEPs; Sulejmanpasic and Drnda, 2017). Most of the above studies focused on brain activation using functional magnetic resonance imaging with high spatial resolution but relatively poor temporal resolution.…”