Magnetic resonance imaging may be an asset to diagnose and classify fluoroquinolone‐associated Achilles tendinitis

Gillet, Philippe; Blum, A; Hestin, D.; Pourel, J; Pierfitte, C.; Mainard, Didier; Keßler, Manuel; Netter, Patrick

doi:10.1111/j.1472-8206.1995.tb00265.x

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…Data include the implicated fluoroquinolone, dose and duration of therapy when the tendon injury occurred, the tendon involved, time to onset of injury, the intervention(s) taken, time to recovery, and potential predisposing factors. The following text summarizes these 60 cases presented in table 1 and, when available, includes details from grouped data from case series [36][37][38][39][40], for a denominator of 98 cases. A comparison with the retrospective studies is presented in the discussion.…”

Section: Resultsmentioning

confidence: 99%

Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature

Khaliq

Zhanel

2003

Clinical Infectious Diseases

301

254

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With the expanded use of fluoroquinolones for the treatment of community-acquired respiratory infections and reports of tendon injury linked to the use of these agents, we reviewed the literature to investigate the frequency and strength of this association. Ninety-eight case reports were available for review. The incidence of tendon injury associated with fluoroquinolone use is low in a healthy population but increases in patients who have renal dysfunction, who are undergoing hemodialysis, or who have received renal transplants. Pefloxacin and ciprofloxacin were most frequently implicated, but tendon injury was reported with most fluoroquinolones. The median duration of fluoroquinolone treatment before the onset of tendon injury was 8 days, although symptoms occurred as early as 2 hours after the first dose and as late as 6 months after treatment was stopped. Up to one-half of patients experienced tendon rupture, and almost one-third received long-term corticosteroid therapy. Tendon injury associated with fluoroquinolone use is significant, and risk factors such as renal disease or concurrent corticosteroid use must be considered when these agents are prescribed.

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Section: Resultsmentioning

confidence: 99%

Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature

Khaliq

Zhanel

2003

Clinical Infectious Diseases

301

254

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“…1a), a finding compatible with mucoid degeneration secondary to hypoxia in the tendon [6]. Peritendinitis was also visible as described previously [5]. In contrast, in cases of tendon and/or peritendinous infection, MRI shows a variety of signals such as circular enhancement of a tendon passing through an area of cellulitis, peritendinous fluid rim, thickening of the tendon diameter and contrast enhancement of the tendon [7].…”

Section: To the Editormentioning

confidence: 60%

“…The most typical feature is the presence of longitudinal intratendinous changes on a sagittal T2-weighed sequence [5]. In this case, MRI images disclosed a zone of high signal intensity in the Achilles tendon (Fig.…”

Section: To the Editormentioning

confidence: 98%

Levofloxacin-associated Achilles tendinitis in a patient with chronic kidney disease stage 5

2011

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“…MRI may be useful for the early detection and monitoring of tendinitis or tendon degeneration 17. Moreover, once FQ-induced tendinopathy is suspected, a patient should not be rechallenged by quinolone treatment 18.…”

Section: Discussionmentioning

confidence: 99%

Levofloxacin-Induced Achilles Tendinitis in a Young Adult in the Absence of Predisposing Conditions

et al. 2010

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Fluoroquinolones (FQs) represent a major class of antimicrobials that have a high potential as therapeutic agents. Although FQs are generally safe for the use as antimicrobials, they may induce tendinopathic complications such as tendinitis and tendon rupture. A number of factors have been suggested to further predispose a patient to such injuries. Hitherto, a few published cases on tendon disorders have implicated levofloxacin, a more recently introduced FQ. Here, we report a patient with levofloxacin-induced Achilles tendinitis, who exhibited no known predisposing factors. A 20-year-old man without any history of disease or medication presented with community-acquired pneumonia. Levofloxacin was administered and 3 days later, he complained of pain in the left Achilles tendon and revealed redness and swelling in the area. On suspecting Achilles tendinitis, levofloxacin treatment was discontinued, and the tendinitis subsequently improved. To our knowledge, this is the first case report on FQ-induced Achilles tendinitis in Korea.

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Magnetic resonance imaging may be an asset to diagnose and classify fluoroquinolone‐associated Achilles tendinitis

Cited by 15 publications

References 9 publications

Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature

Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature

Levofloxacin-associated Achilles tendinitis in a patient with chronic kidney disease stage 5

Levofloxacin-Induced Achilles Tendinitis in a Young Adult in the Absence of Predisposing Conditions

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