Magnetic Resonance Imaging in Young Adults with Cystic Fibrosis

Fiel, Stanley B.; Friedman, Arnold C.; Caroline, Dina F.; Radecki, Paul D.; Faerber, Eric N.; Grumbach, Kathryn

doi:10.1378/chest.91.2.181

Cited by 39 publications

(21 citation statements)

References 3 publications

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“…Magnetic resonance imaging (MRI) of the chest was proposed as a potential imaging alternative in patients with CF in 1987 [7]. But at that time, the technique of MRI was not capable of producing comparable results with CT [8] or adequate clinical input.…”

Section: Introductionmentioning

confidence: 99%

Proton MRI appearance of cystic fibrosis: Comparison to CT

et al. 2006

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Cystic fibrosis (CF) is the most frequent inherited disorder leading to premature death in the Caucasian population. As life expectancy is limited by pulmonary complications, repeated imaging [chest X-ray, multislice high-resolution computed tomography (MS-HRCT)] is required in the follow-up. Magnetic resonance imaging (MRI) of the lung parenchyma is a promising new diagnostic tool. Its value for imaging lung changes caused by CF compared with CT is demonstrated. MRI performs well when compared with CT, which serves as the gold standard. Its lack in spatial resolution is obvious, but advantages in contrast and functional assessment compensate for this limitation. Thus, MRI is a reasonable alternative for imaging the CF lung and should be introduced as a radiation-free modality for follow-up studies in CF patients. For further evaluation of the impact of MRI, systematic studies comparing MRI and conventional imaging modalities are necessary. Furthermore, the value of the additional functional MRI (fMRI) information has to be studied, and a scoring system for the morphological and functional aspect of MRI has to be established.

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Section: Introductionmentioning

confidence: 99%

Proton MRI appearance of cystic fibrosis: Comparison to CT

et al. 2006

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“…[8][9][10][11] Magnetic resonance imaging (MRI) of the lung has increasingly been proposed as a radiation-free diagnostic alternative in patients with CF. [12][13][14] In 1987, Fiel et al 15 first described the use of lung MRI in young adults with CF. However, the early investigations on lung MRI could not provide comparable findings to CT examinations.…”

Section: Discussionmentioning

confidence: 99%

“…However, the early investigations on lung MRI could not provide comparable findings to CT examinations. 15,16 With the development and ongoing improvement of MRI sequences and equipment, such as multichannel radiofrequency coils, the temporal and spatial resolution of lung MRI has been continuously optimized. [17][18][19][20] Puderbach et al 12 found high agreement of morphologic pulmonary changes between MRI and CT in CF.…”

Section: Discussionmentioning

confidence: 99%

“…Results: The overall modified Helbich CT score had a mean (SD) of 15. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and median of 15.0 (IQR, 7.3). Without assessment of perfusion, the overall Eichinger score resulted in the following values for CT vs MR examinations: mean (SD), 20.3 (7.2) (range, 4-31); and median, 21.0 (IQR, 9.5) vs mean (SD), 19.5 (7.1) (range, ; and median, 20.0 (IQR, 9.0).…”

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confidence: 99%

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Comparison Between Magnetic Resonance Imaging and Computed Tomography of the Lung in Patients With Cystic Fibrosis With Regard to Clinical, Laboratory, and Pulmonary Functional Parameters

Renz¹,

Scholz

Böttcher

et al. 2015

Investigative Radiology

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Objective: To evaluate whether magnetic resonance imaging (MRI) is effective as computed tomography (CT) in determining morphologic and functional pulmonary changes in patients with cystic fibrosis (CF) in association with multiple clinical parameters. Materials and Methods: Institutional review board approval and patient written informed consent were obtained. In this prospective study, 30 patients with CF (17 men and 13 women; mean (SD) age, 30.2 (9.2) years; range, 19-52 years) were included. Chest CT was acquired by unenhanced low-dose technique for clinical purposes. Lung MRI (1.5 T) comprised T2-and T1-weighted sequences before and after the application of 0.1-mmol·kg −1 gadobutrol, also considering lung perfusion imaging. All CT and MR images were visually evaluated by using 2 different scoring systems: the modified Helbich and the Eichinger scores. Signal intensity of the peribronchial walls and detected mucus on T2-weighted images as well as signal enhancement of the peribronchial walls on contrast-enhanced T1-weighted sequences were additionally assessed on MRI. For the clinical evaluation, the pulmonary exacerbation rate, laboratory, and pulmonary functional parameters were determined. .2) (range, 4-31); and median, 21.0 (IQR, 9.5) vs mean (SD), 19.5 (7.1) (range, 4-33); and median, 20.0 (IQR, 9.0). All differences between CT and MR examinations were not significant (Wilcoxon rank sum tests and Student t tests; P > 0.05). In general, the correlations of the CT scores (overall and different imaging parameters) to the clinical parameters were slightly higher compared to the MRI scores. However, if all additional MRI parameters were integrated into the scoring systems, the correlations reached the values of the CT scores. The overall image quality was significantly higher for the CT examinations compared to the MRI sequences. Conclusions:One major diagnostic benefit of lung MRI in CF is the possible acquisition of several different morphologic and functional imaging features without the use of any radiation exposure. Lung MRI shows reliable associations with CT and clinical parameters, which suggests its implementation in CF for routine diagnosis, which would be particularly important in follow-up imaging over the long term.

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“…It provides excellent soft tissue contrast and is well accepted for a large field of diagnostic applications outside the lung. The first MR study in patients with cystic fibrosis (CF) performed in 1987 did not show any comparable results to CT [3,4]. Technological developments have since essentially improved the image quality of chest MR [5].…”

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confidence: 99%

Clinical Application of MRI in Children for the Assessment of Pulmonary Diseases

Ley‐Zaporozhan¹,

Ley²,

Sommerburg³

et al. 2009

Fortschr Röntgenstr

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The standard examination technique for the chest in children is an X-ray examination - it is fast, cheap and provides a good overview of anatomy and pathology. In cases with an unclear pathology or if more details are needed (i. e. pre-therapeutically), computed tomography is most often performed with the well known drawbacks of limited soft tissue contrast and radiation. Radiation should be avoided in children, especially if follow-up examinations are needed. Recent magnetic resonance (MR) techniques allow for fast and reliable assessment of pulmonary diseases in children. Due to the inherent soft tissue contrast, diagnosis can be frequently performed without contrast media application. This review provides an exemplary MR examination protocol for routine application in pediatric patients. The diagnostic value of MRI is shown in patients with infectious diseases, patients with immunodeficiency, anatomic abnormalities, acquired chronic diseases, and pulmonary tumors. Since MRI is especially suitable for functional imaging, an MR protocol is provided for the examination of thoracic deformities. This review summarizes the use of thoracic MRI in the clinical pediatric setting with special focus on the clinical indications as a radiation-free method.

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Magnetic Resonance Imaging in Young Adults with Cystic Fibrosis

Cited by 39 publications

References 3 publications

Proton MRI appearance of cystic fibrosis: Comparison to CT

Proton MRI appearance of cystic fibrosis: Comparison to CT

Comparison Between Magnetic Resonance Imaging and Computed Tomography of the Lung in Patients With Cystic Fibrosis With Regard to Clinical, Laboratory, and Pulmonary Functional Parameters

Clinical Application of MRI in Children for the Assessment of Pulmonary Diseases

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