Magnetic resonance imaging in the evaluation of the fetal spinal canal contents

Duczkowska, Agnieszka; Bekiesińska‐Figatowska, Monika; Herman‐Sucharska, Izabela; Duczkowski, Marek; Romaniuk-Doroszewska, Anna; Jurkiewicz, Elżbieta; Dubis, Anna; Urbanik, Andrzej; Furmanek, Mariusz; Walecki, Jerzy

doi:10.1016/j.braindev.2010.01.003

Cited by 35 publications

(34 citation statements)

References 16 publications

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“…Determination of the level of the lesion on fetal MR images is indispensable as it informs the counseling of parents about the likelihood of their child having shunt-dependent hydrocephalus and his or her likely leg function; furthermore, it guides treatment strategy, which may include termination of pregnancy, conventional postnatal closure or intrauterine repair [20,21,22,23]. We found that prenatal MR images were suitable for these purposes, in agreement with other investigators [1,3,5,17,24,25,26,27,28,29]. The presence of a skin defect and enlarged CSF space on prenatal MR images allowed the diagnosis to be made without difficulty and the approximate level of MMC to be established in all cases.…”

Section: Discussionsupporting

confidence: 86%

“…Split cord malformation and syringohydromyelia are extracranial pathologies that can occur with MMC or independently [24]. In our series, small syrinxes were detected in 5 cases, and diastematomyelia was detected in 2 cases on hT2WI.…”

Section: Discussionmentioning

confidence: 53%

“…It has been proposed that hindbrain herniation should be graded on the basis of the location of the 4th ventricle [24] or the ability to visualize the 4th ventricle together with the extent of displacement of the cerebellum [17]. Neither system appears to be widely used, and their relationship with clinical findings such as severity of hydrocephalus or neurological deficits has not been fully established.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Significance of Prenatal and Postnatal Heavily T2-Weighted Magnetic Resonance Images in Patients with Myelomeningocele

et al. 2015

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Purpose: To compare the utility and limitations of prenatal magnetic resonance (MR) imaging using half-Fourier acquisition single-shot turbo spin-echo (HASTE) with postnatal heavily T2-weighted imaging (hT2WI) for the evaluation of central nervous system abnormalities associated with myelomeningocele (MMC). Methods: Sixteen patients with MMC who had undergone pre- and postnatal MR imaging were included in this study. MR imaging, including HASTE, was undertaken in the 3rd trimester, and hT2WI was performed immediately after delivery. The precision with which each could distinguish MMC, hindbrain herniation and ventriculomegaly was compared retrospectively. Results: The skin defects and MMC sacs were clearly visible on prenatal HASTE images, although it was difficult to identify precisely the level of MMC compared with postnatal hT2WI, in which the detailed anatomical relationships of the spinal cord, neural placode and ventral nerve roots were evident in every case. Hindbrain herniation could be visualized on prenatal HASTE images, although its severity was difficult to evaluate because of the small size of the structures and neck flexion; again, the resolution was superior on postnatal hT2WI. For hydrocephalus, there were no significant differences in the diagnostic precision and ability to grade the severity between pre- and postnatal imaging. Conclusion: Prenatal HASTE imaging permits the diagnosis and understanding of the gross anatomy of MMC and associated hindbrain herniation and ventriculomegaly, but postnatal hT2WI is superior for evaluating detailed anatomy.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Clinical Significance of Prenatal and Postnatal Heavily T2-Weighted Magnetic Resonance Images in Patients with Myelomeningocele

et al. 2015

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“…The superiority of lumbosacral magnetic resonance imaging for diagnosis, both antenatal and postnatal, and for classification, is generally accepted today. It also readily detects various associated anomalies [34][35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Crs and Associated Anomalies Of Other Systemsmentioning

confidence: 99%

Etiology of Caudal Regression Syndrome

Semba¹,

Yamamura²

2013

Human Genet Embryol

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Caudal regression syndrome (CRS) is a rare congenital disorder in which lumbosacral anomalies are combined with anorectal and urogenital malformations. However, the molecular mechanisms of human CRS are not yet known. Trauma, nutritional problems, toxic agents, and genetics are suggested in the etiology of CRS. To the best of our knowledge, linkage studies of families affected exclusively by CRS or total sacral agenesis have not been conducted. In spite of the small number of familial cases reported, some specific genes have been shown to cause defined phenotypes. Environmental factors also may act as an enhancer in the etiology for CRS. There are several mutant mice that are considered as models for CRS, showing characteristic vertebral, anorectal, and urogenital abnormalities. Understanding the mechanisms for CRS development gives us valuable information to understand better what mutations may cause or contribute to CRS in humans. This review highlights the current evidence that pinpoints the link to the etiology of CRS.

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“…Пренатальная диагно-стика клинически возможна на 20-22 неделе беременности по УЗИ [8]. Для окончательной постановки диа-гноза проводится МРТ-обследование [12,19,20].…”

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