Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications

Dasgupta, Archya; Maitre, Priyamvada; Pungavkar, Sona; Gupta, Tejpal

doi:10.1007/978-1-0716-1952-0_18

Cited by 6 publications

(3 citation statements)

References 86 publications

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“…SHH in the cerebellar hemispheres, WNT in the brainstem) 6 and morphological appearances/enhancement characteristics (e.g. SHH tumours with DN pathology), 28 which are readily discerned by conventional MRI. Radiomic features of conventional MRI have also been shown to be powerful characteristics of medulloblastoma molecular group.…”

Section: Discussionmentioning

confidence: 99%

Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups

Kohe,

Bennett,

Burté

et al. 2024

eBioMedicine

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Section: Discussionmentioning

confidence: 99%

Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups

Kohe,

Bennett,

Burté

et al. 2024

eBioMedicine

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“…Preoperative spinal MRI is routinely performed to assess for leptomeningeal metastasis. Postoperative MRI is frequently obtained after 24–48 hours to assess the extent of tumour resection 8. In our case, an additional spinal MRI was performed on postoperative day 3 to evaluate developing signs of posterior fossa syndrome.…”

Section: Descriptionmentioning

confidence: 99%

Postoperative epidural enhancement in a child with metastatic medulloblastoma

Ho,

Crawford

2024

BMJ Case Rep

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“…Imaging is less successful at detecting molecular changes or changes at the cellular level since it primarily records structural changes in tissues. It can be challenging to discern between actual disease progression and pseudo-progression caused by inflammation [ 36 ]. Small alterations in size or structure might not be effectively detected, which might result in the treatment response being misinterpreted.…”

Section: Reviewmentioning

confidence: 99%

Liquid Biopsies for Monitoring Medulloblastoma: Circulating Tumor DNA as a Biomarker for Disease Progression and Treatment Response

Buccilli,

Rodriguez Molina,

Redrovan Palomeque

et al. 2024

Cureus

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Pediatric brain tumors, including medulloblastoma (MB), represent a significant challenge in clinical oncology. Early diagnosis, accurate monitoring of therapeutic response, and the detection of minimal residual disease (MRD) are crucial for improving outcomes in these patients. This review aims to explore recent advancements in liquid biopsy techniques for monitoring pediatric brain tumors, with a specific focus on medulloblastoma. The primary research question is how liquid biopsy techniques can be effectively utilized for these purposes. Liquid biopsies, particularly the analysis of circulating tumor DNA (ctDNA) in cerebrospinal fluid (CSF), are investigated as promising noninvasive tools. This comprehensive review examines the components of liquid biopsies, including ctDNA, cell-free DNA (cfDNA), and microRNA (miRNA). Their applications in diagnosis, prognosis, and MRD assessment are critically assessed. The review also discusses the role of liquid biopsies in categorizing medulloblastoma subgroups, risk stratification, and the identification of therapeutic targets. Liquid biopsies have shown promising applications in the pediatric brain tumor field, particularly in medulloblastoma. They offer noninvasive means of diagnosis, monitoring treatment response, and detecting MRD. These biopsies have played a pivotal role in subgroup classification and risk stratification of medulloblastoma patients, aiding in the identification of therapeutic targets. However, challenges related to sensitivity and specificity are noted. In conclusion, this review highlights the growing importance of liquid biopsies, specifically ctDNA analysis in CSF, in pediatric brain tumor management, with a primary focus on medulloblastoma. Liquid biopsies have the potential to revolutionize patient care by enabling early diagnosis, accurate monitoring, and MRD detection. Nevertheless, further research is essential to validate their clinical utility fully. The evolving landscape of liquid biopsy applications underscores their promise in improving outcomes for pediatric brain tumor patients.

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Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications

Cited by 6 publications

References 86 publications

Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups

Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups

Postoperative epidural enhancement in a child with metastatic medulloblastoma

Liquid Biopsies for Monitoring Medulloblastoma: Circulating Tumor DNA as a Biomarker for Disease Progression and Treatment Response

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