Magnetic Resonance Imaging in Patients with Unexplained Optic Neuropathy

Golnik, Karl C.; Hund, Paul; Stroman, Gesa A.; Stewart, William C.

doi:10.1016/s0161-6420(96)30664-7

Cited by 30 publications

(14 citation statements)

References 17 publications

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“…These results agree with previous numerous case reports or small case series which described the occurrence of intracranial tumours, mostly perisellar tumours, in patients with the diagnosis of normal-pressure glaucoma (Gittinger et al 1981;Gutman et al 1993;Bianchi-Marzoli et al 1995;Ong et al 1995;Stroman et al 1995;Colapinto et al 1996;Golnik et al 1996;Greenfield et al 1998;Greenfield 1999;Ahmed et al 2002;Kashiwagi et al 2004;Mejico et al 2004;Greenfield & Bagga 2005;Blumenthal et al 2006). Our study included a considerably larger study population and additionally compared the prevalence of a glaucoma-like optic disc appearance with an age-matched population-based control group.…”

Section: Discussionsupporting

confidence: 92%

“…These features also apply for patients with normal-pressure glaucoma, in whom despite a normal intraocular Glaucoma-like optic neuropathy in patients with intracranial tumours pressure, the optic nerve head shows morphologic characteristics of highpressure glaucoma (Jonas & Xu 1993a,b;Jonas & Budde 1999. Few clinical reports, however, described patients with a glaucoma-like appearance of the optic disc, in whom the intraocular pressure was normal and who suffered from a cerebral tumour, usually located in the intrasellar or perisellar region (Trobe et al 1980;Gittinger et al 1981;Bianchi-Marzoli et al 1995;Ong et al 1995;Stroman et al 1995;Golnik et al 1996;Greenfield et al 1998;Greenfield 1999;Ahmed et al 2002;Kashiwagi et al 2004;Mejico et al 2004;Greenfield & Bagga 2005;Blumenthal et al 2006), or who had an aneurysm of the internal carotid artery in touch with the optic nerve close to the optic canal (Gutman et al 1993;Colapinto et al 1996;Jacobson 1999;Ogata et al 2005). It has remained inconclusive so far, whether the coincidence of tumour and glaucoma-like optic neuropathy in these patients was incidental or whether it was causally related.…”

Section: Introductionmentioning

confidence: 99%

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Glaucoma-like optic neuropathy in patients with intracranial tumours

Wang

et al. 2011

Acta Ophthalmologica

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ABSTRACT.Purpose: To examine frequency and associated factors of glaucoma-like appearance of the optic nerve head in patients with intrasellar, suprasellar or parasellar tumours. Methods: This retrospective clinical observational study included patients who were consecutively treated for intrasellar tumours (n = 143), suprasellar tumours (n = 321), parasellar tumours (n = 36) or retrosellar tumour (n = 1), and all of whom had undergone fundus photography and full-threshold visual field examination. The tumour spectrum included 336 pituitary gland tumours, 32 meningiomas, 89 craniopharyngiomas, 9 chiasmal gliomas and 35 other types of tumours or lesions. An age-matched control group was formed from the population-based Beijing Eye Study. Using fundus photographs and visual field examinations, glaucoma was defined by a neuroretinal rim shape not following the ISNT rule (Disc glaucoma group) and by an abnormal rim shape plus glaucoma-like visual field defects (Field glaucoma group). Type and size of the tumours were assessed on neuroradiological images. Results: Five-hundred and one patients fulfilled the inclusion criteria. Disc glaucoma and Field glaucoma were detected significantly more frequently in the study population [34 (6.8%) patients and 31 (6.3%) patients, respectively] than in the population-based control group of the same ethnicity (1.3% ± 0.5%; p < 0.001). In multivariate analysis, presence of Disc glaucoma [odds ratio (OR) = 2.64; p = 0.016] and presence of Field glaucoma (OR = 3.01; p = 0.027) were significantly associated with tumour location [suprasellar > parasellar > intrasellar]. The same held true for tumour width (OR = 1.08; p = 0.002; and OR = 1.08; p = 0.003, respectively). Conclusions: Large perisellar tumours were associated with a glaucoma-like appearance of the optic nerve head in eyes. It may diagnostically and pathogenetically be of importance.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Glaucoma-like optic neuropathy in patients with intracranial tumours

Wang

et al. 2011

Acta Ophthalmologica

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“…It is surrounded by meninges, and a subarachnoid space that is continuous with the corresponding intracranial subarachnoid space around the brain and spinal cord. MRI studies of the optic nerve evolved in an early attempt to understand the pathophysiology of low-tension glaucoma (Stroman et al, 1995), and other optic neuropathies (Golnik et al, 1996).…”

Section: Optic Nerve Anatomy and Normal Ageingmentioning

confidence: 99%

Lateral thinking – Interocular symmetry and asymmetry in neurovascular patterning, in health and disease

Cameron

Megaw

Tatham

et al. 2017

Progress in Retinal and Eye Research

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No biological system or structure is likely to be perfectly symmetrical, or have identical right and left forms. This review explores the evidence for eye and visual pathway asymmetry, in health and in disease, and attempts to provide guidance for those studying the structure and function of the visual system, where recognition of symmetry or asymmetry may be essential. The principal question with regards to asymmetry is not 'are the eyes the same?', for some degree of asymmetry is pervasive, but 'when are they importantly different?'. Knowing if right and left eyes are 'importantly different' could have significant consequences for deciding whether right or left eyes are included in an analysis or for examining the association between a phenotype and ocular parameter. The presence of significant asymmetry would also have important implications for the design of normative databases of retinal and optic nerve metrics. In this review, we highlight not only the universal presence of asymmetry, but provide evidence that some elements of the visual system are inherently more asymmetric than others, pointing to the need for improved normative data to explain sources of asymmetry and their impact on determining associations with genetic, environmental or health-related factors and ultimately in clinical practice.

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“…[16][17][18] The occurrence of such compressive damage to the optic nerve is poorly recognised, even though several studies have shown that the optic nerves can be damaged by vascular compression. [19][20][21][22][23][24] Optic nerve compression by the intracranial carotid arteries (ICA) has been suggested to be a cause of visual field defects in patients with optic neuropathy, 19 20 22-25 and in patients with NTG. [26][27][28] The purpose of this study was to examine in more detail whether the compression of the optic nerve by the ICA can be a possible causative factor of NTG.…”

mentioning

confidence: 99%

Optic nerve compression by normal carotid artery in patients with normal tension glaucoma

Ogata

Imaizumi²,

Kurokawa³

et al. 2005

British Journal of Ophthalmology

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Aim: To determine whether compression of the optic nerve by the intracranial carotid artery (ICA) can be a causative factor of normal tension glaucoma (NTG). Methods: The medical records of 103 eyes of 54 Japanese patients with NTG and 104 eyes of 52 age matched control patients were reviewed. The neuroradiological findings of magnetic resonance images (MRI) were evaluated to determine the relation between the optic nerve and ICA. The clinical characteristics and general medical conditions, such as diabetes and systemic hypertension, were also compared between the two groups. Results: The prevalence of optic nerve compression by the ICA in patients with NTG was 49.5%, which was significantly higher than that in control group with 34.6% (p = 0.035). Bilateral compression of the optic nerve was detected in 22 patients with NTG (40.7%), and this was also significantly higher (p = 0.029) than that in the control group (11 patients, 21.2%). In the NTG group, eyes with cup/disc ratio (C/D ratio) >0.7 showed a higher percentage of compression (52.6%) compared with eyes with C/D ratio of ,0.7 (12.5%; p = 0. 042). The presence of diabetes and hypertension did not affect the incidence of optic nerve compression by ICA significantly. Conclusions: The significantly higher percentage of NTG patients who had optic nerve compression by the ICA suggests that compression of the optic nerve by ICA may be a possible causative factor or a risk factor for optic nerve damage in some patients with NTG.

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Magnetic Resonance Imaging in Patients with Unexplained Optic Neuropathy

Cited by 30 publications

References 17 publications

Glaucoma-like optic neuropathy in patients with intracranial tumours

Glaucoma-like optic neuropathy in patients with intracranial tumours

Lateral thinking – Interocular symmetry and asymmetry in neurovascular patterning, in health and disease

Optic nerve compression by normal carotid artery in patients with normal tension glaucoma

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