Magnetic Resonance Imaging in Patients With Low-Tension Glaucoma

Stroman, Gesa A.; Stewart, William C.; Golnik, Karl C.; Curé, Joel K.; Olinger, Rick E.

doi:10.1001/archopht.1995.01100020050027

Cited by 165 publications

(102 citation statements)

References 18 publications

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“…Our findings confirmed the previous TCD study suggesting reduced total cerebral perfusion in open-angle glaucoma patients (high tension and normal tension). 8 The results of this study also support the magnetic resonance imaging studies, which have shown diffuse cerebral ischaemic changes, 15 cerebral infarcts and corpus callosum atrophy in glaucoma patients. 16 Pseudoexfoliation glaucoma is also associated with the alterations in the retrobulbar blood flow parameters.…”

Section: Discussionsupporting

confidence: 87%

Cerebral haemodynamics in patients with pseudoexfoliation glaucoma

Akarsu

Ünal

2005

Eye

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Purpose To evaluate the cerebral haemodynamics in patients with pseudoexfoliation glaucoma. Methods A total of 19 consecutive patients with pseudoexfoliation glaucoma and 19 ageand sex-matched healthy volunteers were recruited in a prospective comparative study. The affected eye in patients with unilateral glaucoma and the eye with more advanced lesions in patients with bilateral glaucoma were included in the study, and the ipsilateral middle cerebral arteries (MCA) were evaluated. While in the controls, the study eye and the ipsilateral MCA were chosen randomly. Measurements included systemic arterial pressure, heart rate, intraocular pressure (IOP), and transcranial colour Doppler parameters, including peak systolic velocity (PSV), end-diastolic velocity (EDV), time-averaged maximum velocity (TAMAX), resistivity index (RI), and pulsatility index (PI). Results The mean PSV, EDV, and TAMAX were significantly lower in the patients with pseudoexfoliation glaucoma than in healthy controls (Po0.001, o0.001 and o0.001, respectively). Additionally, patients with pseudoexfoliation glaucoma had significantly higher PI and RI than healthy controls (P ¼ 0.001 and 0.04, respectively). Systolic and diastolic blood pressures (P ¼ 0.19 and 0.91, respectively) and heart rate (P ¼ 0.06) were not different between the groups. The mean IOP were significantly higher in the glaucoma patients compared with the controls (Po0.001). Conclusion This study suggests that pseudoexfoliation glaucoma is associated with a reduction in the blood flow velocity and elevation in the resistance of the MCA.

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Section: Discussionsupporting

confidence: 87%

Cerebral haemodynamics in patients with pseudoexfoliation glaucoma

Akarsu

Ünal

2005

Eye

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“…The number of retinal ganglion cells lost correlates with the visual field deficit (Quigley et al, 1989). In addition to the retinal ganglion cell body loss, there is loss of the ganglion cell axons, manifested by segmental loss of the nerve fiber layer (Airaksinen et al, 1984;Drance, 1985;Hoyt et al, 1973;Iwata et al, 1985;, increased cup-to-disk ratio, thinning of the optic nerve (Stroman et al, 1995) and chiasm (Iwata et al, 1997), changes in post-synaptic cell counts within the lateral geniculate nucleus (Chaturvedi et al, 1993;Vickers et al, 1997;Weber et al, 2000;Yücel et al, 2000) (the main target of retinal ganglion cell axons in higher animals), and even the cerebral cortex (Crawford et al, 2001;Crawford et al, 2000). Other optic neuropathies include optic neuritis, ischemic optic neuropathy and compressive optic neuropathy, commonly associated with a tumor or aneurysm.…”

Section: Pathologymentioning

confidence: 99%

Stem Cells in Ophthalmology

Wester¹,

Goldberg²

2012

New Advances in Stem Cell Transplantation

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“…A number of studies have shown that this vascular dysfunction and impairment in normal blood flow associated with glaucoma is not restricted to the eye. Indeed, there are also indications of slower flow in peripheral capillary beds (Gasser, 1991) and signs of microvascular encephalopathy, such as white matter lesions (Stroman, 1995). This association between ocular circulation and systemic cardiovascular disease has been extensively studied, with changes in retinal vessel diameters having been shown to predict risk for coronary heart disease, stroke and stroke mortality (Wong, 2001) (Wong, 2002).…”

Section: Altered Blood Flow As a Risk Factor For Glaucoma (Progression)mentioning

confidence: 99%