Magnetic Resonance Imaging in Coronavirus Disease - 2019 Associated Rhino-Orbital-Cerebral Mucormycosis (CA-ROCM) - Imaging Analysis of 50 Consecutive Patients

Yadav, Taruna; Tiwari, Sarbesh; Gupta, Aanchal; Garg, Pawan Kumar; Khera, Pushpinder Singh; Rajagopal, Rengarajan; Goyal, Amit; Soni, Kapil Dev; Chugh, Ankita; Jain, Vidhi; Sureka, Binit; Elhence, Poonam; Misra, Sanjeev

doi:10.1067/j.cpradiol.2021.09.004

Cited by 21 publications

(25 citation statements)

References 16 publications

(21 reference statements)

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“…[ 47 ] India Retrospective Single-center 11 Feb 2020–May 2021 47 ± 11 100 (11) 64 (7) Fouad YA. [ 48 ] Egypt Retrospective Single-center 26 Apr 2021–Aug 2021 63 [46–70] 54 (14) 96 (25) Meher R. [ 49 ] Iran Prospective Single-center 111 May 2021–Jun 2021 53 ± 12 70 (78) 94 (104) Guzman-Castro S. [ 50 ] UK Retrospective Single-center 6 May 2021 52 [45–57] 83 (5) 83 (5) Kumar H. [ 51 ] India Retrospective Single-center 28 Apr 2021–May 2021 54 [48–59] 79 (22) 75 (21) Yadav T. [ 52 ] India Retrospective Single-center 50 Dec 2020–Jun 2021 50 [28–70] 62 (31) 86 (43) Meshram HS. [ 53 ] India Retrospective …”

Section: Resultsmentioning

confidence: 99%

“…[ 47 ] 45 (5) 100 (11) 100 (11) – 36 (4) 0 (0) 36 (4) – Fouad YA. [ 48 ] 27 (7) 12 (3) – – – – 77 (20) – Meher R. [ 49 ] – – – – 27 (30) 5.4 (6) 60 (67) 5.4 (6) Guzman-Castro S. [ 50 ] – – – – 50 (3) 33 (2) 100 (6) – Kumar H. [ 51 ] – – – – 57 (16) 21 (6) 68 (19) – Yadav T. [ 52 ] – – 2.0 (1) – 38 (19) – 44 (22) – Meshram HS. [ 53 ] – 100 (61) 100 (61) – 67 (41) 0 (0) …”

Section: Resultsmentioning

confidence: 99%

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Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Watanabe

Mitaka

et al. 2022

Mycopathologia

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The recent increase of COVID-19-associated mucormycosis (CAM) has been commanding global attention. However, basic epidemiologic characteristics have not firmly been established. In this systematic review and meta-analysis, we sought to determine the clinical manifestations, potential risk factors, and outcomes of CAM. Observational studies reporting CAM were searched with PubMed and EMBASE databases in January 2022. We collected data on comorbidities and treatment for COVID-19, and performed a one-group meta-analysis on the frequency of orbital exenteration procedure and mortality of CAM using a random-effect model. Fifty-one observational studies, including a total of 2,312 patients with proven CAM, were identified. Among the 51 studies, 37 were conducted in India, 8 in Egypt, and 6 in other countries. The most common comorbidity was diabetes mellitus (82%). While 57% required oxygenation, 77% received systemic corticosteroids. Among CAM, 97% were rhino-orbital-cerebral (ROCM), and 2.7% were pulmonary mucormycosis. Usual presentations were headache (54%), periorbital swelling/pain (53%), facial swelling/pain (43%), ophthalmoplegia (42%), proptosis (41%), and nasal discharge/congestion (36%). Regarding the outcomes, orbital exenteration was performed in 17% (95% CI: 12–21%, I 2 = 83%) of the COVID-19-associated ROCM patients. The mortality of CAM was 29% (95% CI; 22–36%, I 2 = 92%). In conclusion, this systematic review and meta-analysis indicated that the most prevalent type of CAM was ROCM, and most CAM patients had diabetes mellitus and received systemic glucocorticoids. Clinicians in the endemic areas should have a high index of suspicion for this invasive fungal complication of COVID-19 when a diabetic patient who received high-dose systemic glucocorticoids developed rhino-orbital symptoms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Watanabe

Mitaka

et al. 2022

Mycopathologia

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“…The identification of fungal etiology and early signs of disease extension outside the paranasal sinuses aids in the diagnosis of invasive fungal sinusitis. On computed tomography (CT), hyperdense lesions in paranasal sinuses, nodular mucosal thickening, and absence of air-fluid level suggest fungal etiology [ 14 ]. CT allows a fair assessment of premaxillary and retroantral fat, one of the earliest and most common sites for fungal invasion which can occur without any obvious bony rarefaction or dehiscence of maxillary sinus walls [ 14 , 15 ].…”

Section: Main Textmentioning

confidence: 99%

“…On computed tomography (CT), hyperdense lesions in paranasal sinuses, nodular mucosal thickening, and absence of air-fluid level suggest fungal etiology [ 14 ]. CT allows a fair assessment of premaxillary and retroantral fat, one of the earliest and most common sites for fungal invasion which can occur without any obvious bony rarefaction or dehiscence of maxillary sinus walls [ 14 , 15 ]. Bone involvement in the form of erosion, expansion, or thinning is reliable indicators for invasiveness and can readily be demonstrated on CT [ 15 , 16 ].…”

Section: Main Textmentioning

confidence: 99%

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Intracranial manifestations of rhinocerebral mucormycosis: a pictorial essay

Agrawal

Tripathi

Shukla

et al. 2022

Egypt J Radiol Nucl Med

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Rhinocerebral mucormycosis has emerged as a common coinfection in coronavirus disease 2019 (COVID-19) patients during the convalescence period. Frequent spread of disease from sinonasal mucosa to bone, neck spaces, orbit, and brain occurs along the perivascular/perineural routes or through direct invasion. Brain involvement represents severe manifestation and is often associated with poor functional outcomes and high mortality rates. Magnetic resonance imaging (MRI) is the modality of choice for the intracranial assessment of disease severity in mucormycosis. Early and accurate identification of intracranial extension is imperative to improve survival rates. With this pictorial essay, we aim to familiarize the readers with the cross-sectional imaging features of intracranial complications of mucormycosis. The radiological details in this essay should serve as a broad checklist for radiologists and clinicians while dealing with this fulminant infection.

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Radiological features of COVID‐19‐associated mucormycosis: A report of 36 cases along with a literature review

Omranzadeh,

Afzalzadeh,

Ghodsi

et al. 2023

Clinical Case Reports

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Magnetic Resonance Imaging in Coronavirus Disease - 2019 Associated Rhino-Orbital-Cerebral Mucormycosis (CA-ROCM) - Imaging Analysis of 50 Consecutive Patients

Cited by 21 publications

References 16 publications

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Intracranial manifestations of rhinocerebral mucormycosis: a pictorial essay

Radiological features of COVID‐19‐associated mucormycosis: A report of 36 cases along with a literature review

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