Magnetic resonance imaging in children with sickle cell disease—detecting alterations in the apparent diffusion coefficient in hips with avascular necrosis

MacKenzie, J. D.; Hernández, Andrea; Pena, Andres; Ruppert, K.; Khrichenko, Dmitry; Gonzalez, Leonardo; Jawad, Abbas F.; Wells, Lawrence; Smith‐Whitley, Kim; Jaramillo, Diego

doi:10.1007/s00247-011-2327-5

Cited by 13 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrarily to other organs where diffusion is restricted in ischaemic condition, the majority of papers on FHAVN have shown its increase in the femoral epiphysis ( Figure 4) (40). Similar results were obtained also considering the Legg-Calvè-Perthes (LCP) disease (41,42). This phenomenon is likely due to the different cell population which constitutes the bone marrow and to a late identification of the pathologic process, when cells death with membranes lysis and BME has already occurred.…”

Section: Advanced Magnetic Resonance Imagingsupporting

confidence: 64%

The role of imaging in diagnosis and management of femoral head avascular necrosis

Manenti

Altobelli

Pugliese

et al. 2015

ccmbm

View full text Add to dashboard Cite

SummaryThe aim of this paper is to critically review the literature documenting the imaging approach in adult Femoral Head Avascular Necrosis (FHAVN). For this purpose we described and evaluated different radiological techniques, such as X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Nuclear Medicine. Plain films are considered the first line imaging technique due to its ability to depict femoral head morphological changes, to its low costs and high availability. CT is not a routinely performed technique, but is useful to rule out the presence of a subchondral fracture when MRI is doubtful or contraindicated. MRI is unanimously considered the gold standard technique in the early stages, being capable to detect bone marrow changes such as edema and sclerosis. It may be useful also to guide treatment and, as CT, it is a validated technique in follow-up of patients with FHAVN. Nuclear medicine imaging is mostly applied in post-operative period to detect graft viability or infective complications. More advanced techniques may be useful in particular conditions but still need to be validated; thus new research trials are desirable. In conclusion, X-ray examination is the first line approach, but lacks of sensitivity in early stage whereas MRI is indicated. CT easily depicts late stage deformation and may decrease MRI false positive results in detecting the subchondral fracture. However, the role of both Nuclear Medicine Imaging and advanced MR techniques in FHAVN still need to be investigated.

show abstract

Section: Advanced Magnetic Resonance Imagingsupporting

confidence: 64%

The role of imaging in diagnosis and management of femoral head avascular necrosis

Manenti

Altobelli

Pugliese

et al. 2015

ccmbm

View full text Add to dashboard Cite

show abstract

“…Foci of osteonecrosis as a result of femoral neck fractures are common and have been reported in up to 75 % of cases at histologic evaluation [ 47 ]. MRI with a diffusion sequence, T2 mapping, and apparent diffusion coefficient (ADC) mapping has also been advocated more recently to evaluate epiphyseal osteonecrosis, although these techniques remain investigational [ [168] , [169] , [170] ].…”

Section: Imaging Features Of Osteonecrosismentioning

confidence: 99%

Evolutionary course of the femoral head osteonecrosis: Histopathological - radiologic characteristics and clinical staging systems

Chen

Liu

et al. 2022

Journal of Orthopaedic Translation

View full text Add to dashboard Cite

“…Foci of ON as a result of femoral neck fractures are common and have been reported in up to 75% of cases at histologic evaluation (45). MR imaging with a diffusion sequence, T2 mapping, and apparent diffusion coefficient (ADC) mapping has also been advocated more recently to evaluate epiphyseal ON, although these techniques remain investigational (2,(46)(47)(48).…”

Section: Imaging Of Adult Osteonecrosismentioning

confidence: 99%

From the Radiologic Pathology Archives Imaging of Osteonecrosis: Radiologic-Pathologic Correlation

Murphey¹,

Foreman²,

et al. 2014

View full text Add to dashboard Cite

Osteonecrosis is common and represents loss of blood supply to a region of bone. Common sites affected include the femoral head, humeral head, knee, femoral/tibial metadiaphysis, scaphoid, lunate, and talus. Symptomatic femoral head osteonecrosis accounts for 10,000-20,000 new cases annually in the United States. In contradistinction, metadiaphyseal osteonecrosis is often occult and asymptomatic. There are numerous causes of osteonecrosis most commonly related to trauma, corticosteroids, and idiopathic. Imaging of osteonecrosis is frequently diagnostic with a serpentine rim of sclerosis on radiographs, photopenia in early disease at bone scintigraphy, and maintained yellow marrow at MR imaging with a serpentine rim of high signal intensity (double-line sign) on images obtained with long repetition time sequences. These radiologic features correspond to the underlying pathology of osseous response to wall off the osteonecrotic process and attempts at repair with vascularized granulation tissue at the reactive interface. The long-term clinical importance of epiphyseal osteonecrosis is almost exclusively based on the likelihood of overlying articular collapse. MR imaging is generally considered the most sensitive and specific imaging modality both for early diagnosis and identifying features that increase the possibility of this complication. Treatment subsequent to articular collapse and development of secondary osteoarthritis typically requires reconstructive surgery. Malignant transformation of osteonecrosis is rare and almost exclusively associated with metadiaphyseal lesions. Imaging features of this dire sequela include aggressive bone destruction about the lesion margin, cortical involvement, and an associated soft-tissue mass. Recognizing the appearance of osteonecrosis, which reflects the underlying pathology, improves radiologic assessment and is important to guide optimal patient management.

show abstract

Magnetic resonance imaging in children with sickle cell disease—detecting alterations in the apparent diffusion coefficient in hips with avascular necrosis

Abstract: Children with sickle cell disease have elevated apparent diffusion coefficient values in their affected hips on initial diagnosis of avascular necrosis.

Cited by 13 publications

References 16 publications

The role of imaging in diagnosis and management of femoral head avascular necrosis

The role of imaging in diagnosis and management of femoral head avascular necrosis

Evolutionary course of the femoral head osteonecrosis: Histopathological - radiologic characteristics and clinical staging systems

From the Radiologic Pathology Archives Imaging of Osteonecrosis: Radiologic-Pathologic Correlation

Contact Info

Product

Resources

About